Elizabeth Finger
A5072242679- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Amyotrophic Lateral Sclerosis Research
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Prion Diseases and Protein Misfolding
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological diseases and metabolism
- Genetic Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Neurogenetic and Muscular Disorders Research
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Infant Health and Development
- Neural and Behavioral Psychology Studies
- Genomics and Rare Diseases
- Bioinformatics and Genomic Networks
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Health, Environment, Cognitive Aging
- Cerebrospinal fluid and hydrocephalus
- Cancer, Hypoxia, and Metabolism
- Psychosomatic Disorders and Their Treatments
- Neurobiology of Language and Bilingualism
Western University
2016-2025
St Joseph's Health Care
2015-2025
Lawson Health Research Institute
2016-2024
University of Antwerp
2024
Parkwood Institute
2016-2024
Ludwig-Maximilians-Universität München
2022-2024
Universidad de Granada
2024
University of California, San Francisco
2014-2024
Inserm
2024
Mayo Clinic in Florida
2010-2024
Objective: Extensive work implicates abnormal amygdala activation in emotional facial expression processing adults with callous-unemotional traits. However, no research has examined response to expressions adolescents disruptive behavior and Moreover, despite high comorbidity of traits attention deficit hyperactivity disorder (ADHD), attempted distinguish neural correlates pediatric ADHD. Method: Participants were 36 children (ages 10–17 years); 12 had either conduct or oppositional defiant...
Frontotemporal dementia is a highly heritable neurodegenerative disorder. In about third of patients, the disease caused by autosomal dominant genetic mutations usually in one three genes: progranulin (GRN), microtubule-associated protein tau (MAPT), or chromosome 9 open reading frame 72 (C9orf72). Findings from studies other dementias have shown neuroimaging and cognitive changes before symptoms onset, we aimed to identify whether such could be frontotemporal dementia.
Eosinophil accumulation is a distinctive feature of lung allergic inflammation. Here, we have used mouse model OVA (ovalbumin)-induced pulmonary eosinophilia to study the cellular and molecular mechanisms for this selective recruitment eosinophils airways. In there was an early infiltrating monocytes/macrophages in during treatment, whereas increase T-lymphocytes paralleled eosinophils. The kinetics these three leukocyte subtypes correlated with levels mRNA expression chemokines monocyte...
Abstract The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct trajectories. Here we introduce machine-learning technique—Subtype Stage Inference (SuStaIn)—able uncover data-driven with temporal progression patterns, from widely available cross-sectional patient studies. Results imaging studies in two reveal subgroups their trajectories regional...
Children and adults with psychopathic traits conduct or oppositional defiant disorder demonstrate poor decision making are impaired in reversal learning. However, the neural basis of this impairment has not previously been investigated. Furthermore, despite high comorbidity attention-deficit/hyperactivity disorder, to our knowledge, no research attempted distinguish correlates childhood disorder.To determine regions that underlie learning impairments children plus disorder.Case-control...
Abstract Background A rare variant in the Triggering Receptor Expressed on Myeloid cells 2 ( TREM2 ) gene has been reported to be a genetic risk factor for Alzheimer’s disease by two independent groups (Odds ratio between 2.9-4.5). Given key role of effective phagocytosis apoptotic neuronal microglia, we hypothesized that dysfunction may play more generalized neurodegeneration. With this mind set out assess association disease-related (rs75932628, p.R47H) with other related neurodegenerative...
Objective: Generalized social phobia involves fear/avoidance, specifically of situations, whereas generalized anxiety disorder intrusive worry about diverse circumstances. It remains unclear the degree to which these two, often comorbid, conditions represent distinct disorders or alternative presentations a single, core underlying pathology. Functional magnetic resonance imaging assessed neural response facial expressions in and disorder. Method: Individuals matched on age, IQ, gender with...
Background Psychopathic traits are associated with increases in antisocial behaviors such as aggression and characterized by reduced empathy for others' distress. This suggests that psychopathic may also impair empathic pain sensitivity. However, whether affect responses to the of others versus self has not been previously assessed. Method We used whole‐brain functional magnetic resonance imaging measure neural activation 14 adolescents oppositional defiant disorder or conduct traits, well...
Significance Here we report a fundamental and previously unknown role for the receptor tyrosine kinase AXL as direct hypoxia-inducible transcription factor target driving aggressive phenotype in renal clear cell carcinoma through regulation of SRC proto-oncogene nonreceptor MET kinase. Of therapeutic relevance, demonstrate that inactivation growth arrest-specific 6 (GAS6)/AXL signaling using soluble decoy reversed invasive metastatic (ccRCC) cells. Furthermore, define pathway by which...
Rare mutations in the gene encoding for tau (MAPT, microtubule-associated protein tau) cause frontotemporal dementia-spectrum (FTD-s) disorders, including FTD, progressive supranuclear palsy (PSP) and corticobasal syndrome, a common extended haplotype spanning across MAPT locus is associated with increased risk of PSP Parkinson's disease.We identified rare variant (p.A152T) patient clinical diagnosis assessed its frequency multiple independent series patients neurodegenerative conditions...
There are few validated fluid biomarkers in frontotemporal dementia (FTD). Glial fibrillary acidic protein (GFAP) is a measure of astrogliosis, known pathological process FTD, but has yet to be explored as potential biomarker.Plasma GFAP and neurofilament light chain (NfL) concentration were measured 469 individuals enrolled the Genetic FTD Initiative: 114 C9orf72 expansion carriers (74 presymptomatic, 40 symptomatic), 119 GRN mutation (88 31 53 MAPT (34 19 symptomatic) 183 non-carrier...
Objective: Dysfunction in the amygdala and orbitofrontal cortex has been reported youths adults with psychopathic traits. The specific nature of functional irregularities within these structures remains poorly understood. authors used a passive avoidance task to examine responsiveness systems early stimulus-reinforcement exposure, when prediction errors are greatest learning maximized, reward traits comparison youths. Method: While performing task, 15 conduct disorder or oppositional defiant...
<h3>Objectives:</h3> To determine whether <i>TMEM106B</i> single nucleotide polymorphisms (SNPs) are associated with frontotemporal lobar degeneration (FTLD) in patients and without mutations progranulin (<i>GRN</i>) to modulates <i>GRN</i> expression. <h3>Methods:</h3> We performed a case-control study of 3 SNPs 482 clinical 80 pathologic FTLD–TAR DNA-binding protein 43 mutations, 78 FTLD 822 controls. Association analysis GRN plasma levels was 1,013 controls mRNA expression were correlated...
Abstract The transforming growth factor-β (TGF-β) signaling pathway has an important role in regulating normal prostate epithelium, inhibiting proliferation, differentiation, and both androgen deprivation–induced androgen-independent apoptosis. During cancer formation, most cells become resistant to these homeostatic effects of TGF-β. Although the loss expression either type I (TβRI) or II (TβRII) TGF-β receptor been documented ∼30% cancers, cancers without mutation deletion TβRI, TβRII,...
Frontotemporal dementia (FTD) is a highly heritable condition with multiple genetic causes. In this study, similarities and differences of gray matter (GM) atrophy patterns were assessed among 3 common forms FTD (mutations in C9orf72, GRN, MAPT). Participants from the Genetic Initiative (GENFI) cohort suitable volumetric T1 magnetic resonance imaging scan included (319): 144 nonmutation carriers, 128 presymptomatic mutation 47 clinically affected carriers. Cross-sectional GM volume between...
Expanded glutamine repeats of the ataxin-2 (ATXN2) protein cause spinocerebellar ataxia type 2 (SCA2), a rare neurodegenerative disorder. More recent studies have suggested that expanded ATXN2 are genetic risk factor for amyotrophic lateral sclerosis (ALS) via an RNA-dependent interaction with TDP-43. Given phenotypic diversity observed in SCA2 patients, we set out to determine polymorphic nature repeat length across spectrum disorders. In this study, genotyped 3919 disease patients and 4877...