Mikel Tainta
A5088037670- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Frailty in Older Adults
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Nutritional Studies and Diet
- Functional Brain Connectivity Studies
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Prion Diseases and Protein Misfolding
- Health Systems, Economic Evaluations, Quality of Life
- Neurobiology of Language and Bilingualism
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Genomics and Rare Diseases
- Neurological disorders and treatments
- Neurological Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Aging, Health, and Disability
- Health, Environment, Cognitive Aging
- Epilepsy research and treatment
- Machine Learning in Healthcare
Fundacion CITA Alzheimer
2017-2025
Biogipuzkoa Health Research Institute
2016-2025
Osakidetza
2019-2025
Universidad de Deusto
2024
Biomedical Research Networking Center on Neurodegenerative Diseases
2017-2023
KU Leuven
2022
Diputación Foral de Gipuzkoa
2022
University of Antwerp
2022
Université Laval
2022
Osasun Sistemen Ikerketa Institutua
2020
In Parkinson's disease (PD), the oscillatory activity recorded from basal ganglia shows dopamine-dependent changes. “off” parkinsonian motor state, there is prominent in beta band (12–30 Hz) that mostly attenuated after dopaminergic therapy (“on” medication state). The on state also characterized by gamma (60–80 and high-frequency (300 bands modulated movement. We local field potentials a group of 15 PD patients (three females) treated with bilateral deep brain stimulation subthalamic...
Abstract Reducing the risk of dementia can halt worldwide increase affected people. The multifactorial and heterogeneous nature late‐onset dementia, including Alzheimer's disease (AD), indicates a potential impact multidomain lifestyle interventions on reduction. positive results landmark Finnish Geriatric Intervention Study to Prevent Cognitive Impairment Disability (FINGER) support such an approach. World‐Wide FINGERS (WW‐FINGERS), launched in 2017 over 25 countries, is first global...
Abstract Introduction Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a “Holy Grail” of AD research and intensively sought; however, there no well‐established plasma markers. Methods A hypothesis‐led biomarker search was conducted in the context international multicenter studies. The discovery phase measured 53 inflammatory proteins elderly control (CTL; 259), mild cognitive impairment (MCI; 199), (262) subjects from AddNeuroMed. Results Ten analytes showed...
A biomarker of synapse loss, an early event in Alzheimer's disease (AD) pathophysiology that precedes neuronal death and symptom onset, would be a much-needed prognostic biomarker. With direct access to the brain interstitial fluid, cerebrospinal fluid (CSF) is potential source synapse-derived proteins. In this study, we aimed identify validate novel CSF biomarkers loss AD. Discovery: Combining shotgun proteomics with exhaustive search literature public databases, identified 251 synaptic...
Diagnostic incidence data for syndromes associated with frontotemporal lobar degeneration (FTLD) in multinational studies are urgent light of upcoming therapeutic approaches.To assess the FTLD across Europe.The Frontotemporal Dementia Incidence European Research Study (FRONTIERS) was a retrospective cohort study conducted from June 1, 2018, to May 31, 2019, using population-based registry 13 tertiary research clinics UK, Netherlands, Finland, Sweden, Spain, Bulgaria, Serbia, Germany, and...
Abstract Introduction Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). Methods We included healthy control subjects (N = 254), mild cognitive impairment 41), AD dementia 31) patients. Participants underwent a lumbar puncture 3 T magnetic resonance imaging. Healthy were classified following National Institute on Aging‐Alzheimer's Association stages (stage 0, N 220; stage 1, 25; 2/3, 9). assessed the cortical MD, FW,...
Abstract Introduction We investigated relations between amyloid‐β (Aβ) status, apolipoprotein E ( APOE ) ε4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL‐40, total tau (T‐tau). Methods included 770 individuals normal mild cognitive impairment, Alzheimer's disease (AD)‐type dementia from the EMIF‐AD Multimodal Biomarker Discovery study. tested association Ng, NFL, T‐tau Aβ status (Aβ− vs. Aβ+), clinical diagnosis ε4 carriership, baseline...
Abstract Introduction Within‐person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) are not well defined. Methods We included 467 subjects from the BIOMARKAPD study with at least two serial CSF samples. Diagnoses were subjective cognitive decline (n = 75), mild impairment 128), and AD dementia 110), a group cognitively unimpaired 154) also included. measured baseline follow‐up levels total tau (t‐tau), phosphorylated (p‐tau), YKL‐40, neurofilament light...
Abstract Introduction Machine learning (ML) may harbor the potential to capture metabolic complexity in Alzheimer Disease (AD). Here we set out test performance of metabolites blood categorize AD when compared CSF biomarkers. Methods This study analyzed samples from 242 cognitively normal (CN) people and 115 with AD‐type dementia utilizing plasma (n = 883). Deep Learning (DL), Extreme Gradient Boosting (XGBoost) Random Forest (RF) were used differentiate CN. These models internally validated...
The Mediterranean diet (MD) has shown to reduce the occurrence of several chronic diseases. To evaluate its potential protective role on dementia incidence we studied 16,160 healthy participants from European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain Dementia Cohort study recruited between 1992-1996 followed up for a mean (±SD) 21.6 (±3.4) years. A total 459 incident cases were ascertained through expert revision medical records. Data habitual was collected validated...
Alzheimer’s disease (AD) is the most frequent neurodegenerative with an increasing prevalence in industrialized, aging populations. AD susceptibility has established genetic basis which been focus of a large number genome-wide association studies (GWAS) published over last decade. Most these GWAS used dichotomized clinical diagnostic status, i.e., case vs. control classification, as outcome phenotypes, without use biomarkers. An alternative and potentially more powerful study design afforded...
Abstract Background GOIZ ZAINDU (“caring early” in Basque) is a pilot study to adapt the Finnish Geriatric Intervention Study Prevent Cognitive Impairment and Disability (FINGER) methodology Basque population evaluate feasibility adherence FINGER-like multidomain intervention program. Additional aims included assessment of efficacy on cognition data collection design large trial. Method 1-year, randomized, controlled trial persons aged 60+ years, with Cardiovascular Risk Factors, Aging...
A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites blood associated with as indexed by cerebrospinal fluid (CSF) AD biomarkers.This study analyzed 593 plasma samples selected from European Medical Information Framework for Disease Multimodal Biomarker Discovery study, individuals who were cognitively healthy (n = 242), had mild...
Abstract Introduction Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Most such biomarker studies are targeted specific or biased toward high abundant proteins. Methods 4001 plasma were measured two groups of participants (discovery group = 516, replication 365) selected from the European Medical Information Framework disease Multimodal...
Abstract Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and common form of dementia in elderly. Susceptibility to AD considerably determined by genetic factors which hitherto were primarily identified using case–control designs. Elucidating architecture additional AD-related phenotypic traits, ideally those linked underlying process, holds great promise gaining deeper insights into basis developing better clinical prediction models. To this end, we generated...
<h3>Background and Objective</h3> Mutations in the <i>MAPT</i> gene cause frontotemporal dementia (FTD). Most previous studies investigating neuroanatomical signature of mutations have grouped all different together shown an association with focal atrophy temporal lobe. The variability patterns between each particular mutation is less well-characterized. We aimed to investigate whether there were distinct groups carriers based on their signature. <h3>Methods</h3> applied Subtype Stage...
Structural and functional changes of the choroid plexus (ChP) have been reported in Alzheimer's disease (AD). Nonetheless, role ChP pathogenesis AD remains largely unknown. We aim to unravel relation between functioning core using a unique proteomic approach mice humans. used an APP knock-in mouse model, APPNL-G-F, exhibiting amyloid pathology, study association brain pathology protein tissue CSF liquid chromatography mass spectrometry. Mouse proteomes were investigated at age 7 weeks (n =...
Objective: Nowadays proper detection of cognitive impairment has become a challenge for the scientific community. Alzheimer's Disease (AD), most common cause dementia, high prevalence that is increasing at fast pace towards epidemic level. In not-so-distant future this fact could have dramatic social and economic impact. scenario, an early accurate diagnosis AD help to decrease its effects on patients, relatives society. Over last decades there been useful advances not only in classic...
Abstract Introduction Neurofilament light (NfL), chitinase‐3‐like protein 1 (YKL‐40), and neurogranin (Ng) are biomarkers for Alzheimer's disease (AD) to monitor axonal damage, astroglial activation, synaptic degeneration, respectively. Methods We performed genome‐wide association studies (GWAS) using DNA cerebrospinal fluid (CSF) samples from the EMIF‐AD Multimodal Biomarker Discovery study discovery, Disease Neuroimaging Initiative validation analyses. GWAS were all three CSF linear...
Genome-wide association studies (GWAS) of Alzheimer's disease (AD) have identified several risk loci, but many remain unknown. Cerebrospinal fluid (CSF) biomarkers may aid in gene discovery and we previously demonstrated that six CSF (β-amyloid, total/phosphorylated tau, NfL, YKL-40, neurogranin) cluster into five principal components (PC), each representing statistically independent biological processes. Here, aimed to (1) identify common genetic variants associated with these profiles, (2)...
Extracellular vesicles (EVs) are membrane-bound particles involved in intercellular communication. They carry proteins, lipids, and nucleotides such as microRNAs (miRNAs) from the secreting cell that can modulate target cells. We others have previously described presence of EVs peripheral blood multiple sclerosis (MS) patients postulated them novel biomarkers. However, their immune function MS pathogenesis effect during onset new immunomodulatory therapies on remain elusive. Here, we...
A key symptom of frontotemporal dementia (FTD) is difficulty interacting socially with others. Social cognition problems in FTD include impaired emotion processing and theory mind difficulties, whilst these have been studied extensively sporadic FTD, few studies investigated them familial FTD. Facial Emotion Recognition (FER) Faux Pas (FP) recognition tests were used to study social within the Genetic Frontotemporal Dementia Initiative (GENFI), a large cohort C9orf72, GRN, MAPT mutation...
The established link between DNA methylation and pathophysiology of dementia, along with its potential role as a molecular mediator lifestyle environmental influences, positions blood-derived promising tool for early dementia risk detection.
Abstract Background We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), the effect amyloid positivity on these associations. Methods included 242 CN (105(43%) abnormal amyloid), 278 MCI individuals (183(66%) amyloid) from European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery (EMIF-AD MBD) Alzheimer’s Neuroimaging Initiative (ADNI). For 181 36...