Petroula Proitsi
A5012553649- Alzheimer's disease research and treatments
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Bioinformatics and Genomic Networks
- Dementia and Cognitive Impairment Research
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- Folate and B Vitamins Research
- Cholesterol and Lipid Metabolism
- Amyotrophic Lateral Sclerosis Research
- Neurological diseases and metabolism
- Computational Drug Discovery Methods
- Genetics and Neurodevelopmental Disorders
- Schizophrenia research and treatment
- Neurological Disease Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Inflammation biomarkers and pathways
- Functional Brain Connectivity Studies
- Genomic variations and chromosomal abnormalities
- Mental Health Research Topics
Queen Mary University of London
2024-2025
King's College London
2015-2024
Neuroscience Institute
2011-2024
University College London
2017-2024
UCL Biomedical Research Centre
2024
Perron Institute for Neurological and Translational Science
2024
King's College Hospital
2024
Murdoch University
2024
QIMR Berghofer Medical Research Institute
2018-2022
Czech Academy of Sciences, Institute of Psychology
2021-2022
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified genetic sharing 25 disorders from genome-wide association studies 265,218 patients 784,643 control participants assessed relationship to 17 phenotypes 1,191,588 individuals. Psychiatric common variant risk, whereas neurological appear more distinct one another psychiatric disorders. also identified significant between a number...
Background Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought identify new genes, using an alternative gene-wide analytical approach tests patterns of association within in the powerful genome-wide dataset International Genomics Project Consortium, comprising over 7 m genotypes from 25,580 cases and 48,466 controls. Principal Findings In addition...
Background Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified first strongly supported LOAD susceptibility genes since discovery involvement APOE in early 1990s. We have now exploited these GWAS datasets to uncover key pathophysiological processes. Methodology applied a recently developed tool for mining data biologically meaningful information dataset. The principal findings were then tested an independent...
<h3>Context</h3> Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD). <h3>Objective</h3> To identify plasma proteins associated with AD pathology using a combined proteomic and neuroimaging approach. <h3>Design</h3> Discovery-phase proteomics to correlates pathology. Confirmation validation immunodetection replication set an animal model. <h3>Setting</h3> A multicenter European study (AddNeuroMed) the Baltimore Longitudinal Study Aging....
Amyotrophic lateral sclerosis (ALS) is a spontaneous, relentlessly progressive motor neuron disease, usually resulting in death from respiratory failure within 3 years. Variation the genes SOD1 and TARDBP accounts for small percentage of cases, other have shown association both candidate gene genome-wide studies, but genetic causes remain largely unknown. We performed two independent parallel implicating RNA polymerase II component, ELP3 , axonal biology neuronal degeneration. In first, an...
Abstract Blood proteins and their complexes have become the focus of a great deal interest in context potential as biomarkers Alzheimer's disease (AD). We used SOMAscan assay for quantifying 1001 blood samples from 331 AD, 211 controls, 149 mild cognitive impaired (MCI) subjects. The strongest associations protein levels with AD outcomes were prostate‐specific antigen complexed to α1‐antichymotrypsin (AD diagnosis), pancreatic prohormone diagnosis, left entorhinal cortex atrophy, hippocampus...
Abstract Background Late‐onset Alzheimer's disease (AD) is heritable with 20 genes showing genome‐wide association in the International Genomics of Project (IGAP). To identify biology underlying disease, we extended these genetic data a pathway analysis. Methods The ALIGATOR and GSEA algorithms were used IGAP to associated functional pathways correlated gene expression networks human brain. Results identified an excess curated biological enrichment association. Enriched areas included immune...
Background Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) represent promising targets for intervention. However, the causality of these associations is unclear. We sought to assess causal nature using Mendelian randomization (MR). Methods Findings used SNPs each factor as instrumental variables in MR analyses. considered type 2 diabetes (T2D, NSNPs = 49), fasting glucose (NSNPs 36), insulin resistance 10),...
The aim of this study was to (1) replicate previous associations between six blood lipids and Alzheimer's disease (AD) (Proitsi et al 2015) (2) identify novel lipids, clinical AD diagnosis, progression brain atrophy (left/right hippocampus/entorhinal cortex).
Markers of Alzheimer's disease (AD) are being widely sought with a number studies suggesting blood measures inflammatory proteins as putative biomarkers. Here we report findings from panel 27 cytokines and related in over 350 subjects AD, Mild Cognitive Impairment (MCI) elderly normal controls where also have longitudinal change cognition baseline neuroimaging atrophy. In this study, identify five associated evidence atrophy on MR imaging data particularly whole brain, ventricular entorhinal...
Alzheimer's disease (AD), like other dementias, is characterized by progressive neuronal loss and neuroinflammation in the brain. The peripheral leukocyte response occurring alongside these brain changes has not been extensively studied, but might inform therapeutic approaches provide relevant biomarkers. Using microarrays, we assessed blood gene expression alterations people with AD those mild cognitive at increased risk of developing AD. Of 2,908 differentially expressed probes identified...
Diabetes mellitus is associated with cognitive dysfunction, but it not clear whether the disorder increases risk of conversion from mild impairment to dementia.To determine association between diabetes and dementia in people (Peterson's criteria) a prospective community-based study.People over 65 years old were approached through primary care practices south London, UK, those (n = 103) followed up for 4 years. Presence was established self-report information general practitioners.Nineteen...
Biomarkers for Alzheimer's disease (AD) based on non-invasive methods are highly desirable diagnosis, progression, and monitoring therapeutics. We aimed to study the use of hippocampal volume, entorhinal cortex (ERC) thickness, whole