Cristina Razquín
A5028742920- Nutritional Studies and Diet
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Obesity, Physical Activity, Diet
- Alzheimer's disease research and treatments
- Fatty Acid Research and Health
- Consumer Attitudes and Food Labeling
- Amyotrophic Lateral Sclerosis Research
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Nutrition, Genetics, and Disease
- Atrial Fibrillation Management and Outcomes
- Biochemical Analysis and Sensing Techniques
- Parkinson's Disease Mechanisms and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Alcohol Consumption and Health Effects
- Bioinformatics and Genomic Networks
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Health and Risk Factors
- Nutrition and Health in Aging
- Sodium Intake and Health
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2016-2025
Universidad de Navarra
2016-2025
Instituto de Salud Carlos III
2016-2025
Navarre Institute of Health Research
2016-2025
Institut d'Investigació Sanitària Pere Virgili
2017-2024
Universitat Rovira i Virgili
2017-2024
Centro de Investigación Biomédica en Red
2016-2024
Madrid Institute for Advanced Studies
2022
IMDEA Food
2022
Universidad Autónoma de Madrid
2022
OBJECTIVE The long-term impact of intentional weight loss on cardiovascular events remains unknown. We describe 12-month changes in body and risk factors PREvención con DIeta MEDiterránea (PREDIMED)-Plus, a trial designed to evaluate the effectiveness an intensive lifestyle intervention primary prevention. RESEARCH DESIGN AND METHODS Overweight/obese adults with metabolic syndrome aged 55–75 years (n = 626) were randomized based energy-restricted Mediterranean diet, physical activity...
Background: Although in vitro studies and investigations animal models small clinical populations have suggested that ceramides may represent an intermediate link between overnutrition certain pathological mechanisms underlying cardiovascular disease (CVD), no prospective investigated the association plasma risk of CVD. Methods: The study population consisted 980 participants from PREDIMED trial (Prevención con Dieta Mediterránea), including 230 incident cases CVD 787 randomly selected at...
CHD, coronary heart disease;d, day; erMedDiet, energy-reduced Mediterranean diet (based on the 17-item questionnaire); MedDiet, 14-item 44,45 E, energy intake; LDL, low
The role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk CVD and a Mediterranean diet (MedDiet) intervention may counteract this effect.
The Mediterranean Dietary (MedDiet) Pattern has been linked to many beneficial health effects. This review summarizes the main findings of a prospective cohort study, Seguimiento Universidad de Navarra (SUN) cohort, specifically focused on MedDiet and risk major chronic disease. It is an open in which 22,786 Spanish university graduates have participated since 1999 until February 2018. Data diet, lifestyle clinical diagnosis are collected at baseline every two years. After reviewing 21...
Abstract Background Late‐onset Alzheimer's disease (AD) is heritable with 20 genes showing genome‐wide association in the International Genomics of Project (IGAP). To identify biology underlying disease, we extended these genetic data a pathway analysis. Methods The ALIGATOR and GSEA algorithms were used IGAP to associated functional pathways correlated gene expression networks human brain. Results identified an excess curated biological enrichment association. Enriched areas included immune...
Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk.We conducted case-cohort study nested within the PREDIMED trial, 250 incident cases diagnosed during 3.8 years median follow-up, and random sample 692 participants (639 noncases 53 overlapping cases) without baseline. repeatedly measured 207 plasma known metabolites baseline after 1 year...
There are no human studies assessing the effect of nutritional interventions on plasma brain-derived neurotrophic factor (BDNF) concentrations. The aim this study was to assess role a intervention based Mediterranean diet (MeDiet) BDNF levels.PREvención con Dieta MEDiterránea (PREDIMED) is randomized clinical trial designed primary prevention cardiovascular disease. For analysis, 243 participants from Navarra centre were randomly selected. Participants assigned one three dietary...
High-quality dietary patterns may help prevent chronic disease, but limited data exist from randomized trials about the effects of nutritional and behavioral interventions on changes.To assess effect a physical activity education program quality.Preliminary exploratory interim analysis an ongoing trial. In 23 research centers in Spain, 6874 men women aged 55 to 75 years with metabolic syndrome no cardiovascular disease were enrolled trial between September 2013 December 2016, final...
Mutations in the gene coding for Sequestosome 1 (SQSTM1) have been genetically associated with amyotrophic lateral sclerosis (ALS) and Paget disease of bone. In present study, we analyzed SQSTM1 sequence mutations an extended cohort 1,808 patients frontotemporal lobar degeneration (FTLD), ascertained within European Early-Onset Dementia consortium. As control dataset, sequenced 1,625 individuals whole-exome data 2,274 German (total n = 3,899). Association rare was calculated a meta-analysis...
DNA methylation could be reversible and mouldable by environmental factors, such as dietary exposures. The objective was to analyse whether an intervention with two Mediterranean diets, one rich in extra-virgin olive oil (MedDiet + EVOO) the other nuts nuts), influencing status of peripheral white blood cells (PWBCs) genes. A subset 36 representative individuals were selected within PREvención con DIeta MEDiterránea (PREDIMED-Navarra) trial, three groups high cardiovascular risk volunteers:...
Metabolites of the tryptophan-kynurenine pathway (i.e., tryptophan, kynurenine, kynurenic acid, quinolinic 3-hydroxyanthranilic) may be associated with diabetes development. Using a case-cohort design nested in Prevención con Dieta Mediterránea (PREDIMED) study, we studied associations baseline and 1-year changes these metabolites incident type 2 (T2D).Plasma metabolite concentrations were quantified via LC-MS for n = 641 randomly selected subcohort 251 cases diagnosed during 3.8 years...
Current cardiometabolic disease prevention guidelines recommend increasing dietary unsaturated fat intake while reducing saturated fats. Here we use lipidomics data from a randomized controlled intervention trial to construct multilipid score (MLS), summarizing the effects of replacing with on 45 lipid metabolite concentrations. In EPIC-Potsdam cohort, difference in MLS, reflecting better quality, was associated significant reduction incidence cardiovascular (-32%; 95% confidence interval...