Debby W. Tsuang
A5045026086- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Genetic Associations and Epidemiology
- Parkinson's Disease Mechanisms and Treatments
- Schizophrenia research and treatment
- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- Autism Spectrum Disorder Research
- Genomic variations and chromosomal abnormalities
- Sleep and Wakefulness Research
- Epigenetics and DNA Methylation
- Neurological diseases and metabolism
- Nuclear Receptors and Signaling
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Sleep and related disorders
- Health, Environment, Cognitive Aging
- Folate and B Vitamins Research
- Cholinesterase and Neurodegenerative Diseases
- Ginkgo biloba and Cashew Applications
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Mental Health Research Topics
- Neuroscience and Music Perception
- Functional Brain Connectivity Studies
VA Puget Sound Health Care System
2015-2024
Geriatric Research Education and Clinical Center
2014-2024
University of Washington
2015-2024
University of Puget Sound
2000-2024
VA Northwest Network
2007-2024
VA Portland Health Care System
2006-2024
University of California, San Diego
2012-2024
University of Pennsylvania
2012-2024
Seattle University
1995-2024
University of Miami
2017-2024
Background Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought identify new genes, using an alternative gene-wide analytical approach tests patterns of association within in the powerful genome-wide dataset International Genomics Project Consortium, comprising over 7 m genotypes from 25,580 cases and 48,466 controls. Principal Findings In addition...
Objectives: To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes.
OBJECTIVES : Most clinico‐neuropathological correlative studies of Alzheimer's Disease (AD) are based on research cohorts that not necessarily generalizable to patients seen in the general medical community. In this study, we examine accuracy criteria used diagnosing AD a community‐based case series with memory complaints. DESIGN AND PARTICIPANTS Clinical and neuropathological diagnoses were obtained from 134 evaluated for dementia who subsequently underwent autopsy. SETTING Subjects...
Exploration of the genetic architecture specific endophenotypes may be a powerful strategy for understanding basis schizophrenia.To characterize some key endophenotypic measures selected their reported heritabilities in schizophrenia.Family-based heritability study.Seven sites across United States.At time these initial data analyses, members 183 nuclear families ascertained through probands with schizophrenia had been assessed endophenotypes.Variance component models were used to assess and...
<h3>Objective</h3>To test for an association between the apolipoprotein E (APOE) ϵ4 allele and dementias with synucleinopathy.<h3>Design</h3>Genetic case-control study.<h3>Setting</h3>Academic research.<h3>Patients</h3>Autopsied subjects were classified into 5 categories: dementia high-level Alzheimer disease (AD) neuropathologic changes (NCs) but without Lewy body (LBD) NCs (AD group; n = 244), LBDNCs ADNCs (LBD-AD 224), no or low levels of (pure DLB [pDLB] 91), Parkinson (PDD) (n 81),...
The authors used a custom array of 1,536 single-nucleotide polymorphisms (SNPs) to interrogate 94 functionally relevant candidate genes for schizophrenia and identify associations with 12 heritable neurophysiological neurocognitive endophenotypes in data collected by the Consortium on Genetics Schizophrenia.
<h3>Importance</h3> Neurophysiologic measures of early auditory information processing (EAP) are used as endophenotypes in genomic studies and biomarkers clinical intervention studies. Research schizophrenia has established correlations among EAP, cognition, symptoms, functional outcome. Clarifying these associations by determining the pathways through which deficits EAP affect functioning would suggest when where to therapeutically intervene. <h3>Objectives</h3> To characterize from outcome...
Abstract Background Late‐onset Alzheimer's disease (AD) is heritable with 20 genes showing genome‐wide association in the International Genomics of Project (IGAP). To identify biology underlying disease, we extended these genetic data a pathway analysis. Methods The ALIGATOR and GSEA algorithms were used IGAP to associated functional pathways correlated gene expression networks human brain. Results identified an excess curated biological enrichment association. Enriched areas included immune...
ABSTRACT Background Loss‐of‐function mutations in the GBA gene are associated with more severe cognitive impairment PD, but nature of these deficits is not well understood and whether common polymorphisms influence performance PD yet known. Methods We screened coding region for E326K polymorphism 1,369 patients enrolled at eight sites from Cognitive Genetics Consortium. Participants underwent assessments learning memory (Hopkins Verbal Learning Test–Revised), working memory/executive...
Objective: Many psychotropic medications used to treat schizophrenia have significant anticholinergic properties, which are linked cognitive impairment and dementia risk in healthy subjects. Clarifying the impact of attributable medication burden may help optimize outcomes schizophrenia. The aim this study was comprehensively characterize how affects functioning across multiple domains outpatients. Methods: Cross-sectional data were analyzed using inferential statistics exploratory...
<b>Objective: </b> To examine the neuropsychological profile of dementia patients from a community-based autopsy sample dementia, comparing Alzheimer disease (AD), Lewy body pathology (LBP) alone, and LBP with coexistent AD (AD/LBP). <b>Methods: The authors reviewed 135 subjects study for whom brain tissue was available. Diagnostic groups were determined according to standard neuropathologic methods criteria, presence LBs using α-synuclein immunostaining. Neuropathologically defined...
To assess the association between statin therapy and risk of Alzheimer disease (AD) in a prospective cohort study with documented exposure incident dementia.This is prospective, use dementia probable AD. A 2,356 cognitively intact persons, aged 65 older, were randomly selected from health maintenance organization (HMO), assessed biennially for dementia. Statin was identified using HMO pharmacy database. proportional hazards model as time-dependent covariate used to statin-dementia/AD...
Lewy body (LB) inclusions are one of the pathological hallmarks Parkinson's disease (PD) and dementia with bodies (DLB). One way to better understand process leading LB formation associated pathogenesis responsible for neurodegeneration in PD DLB is examine content inclusions. Here, we performed a proteomic investigation cortical LBs, obtained by laser capture microdissection from neurons temporal cortex patients disease. Analysis over 2500 LBs discovered 296 proteins; those, 17 had been...
<h3>Background</h3> Mutations in the glucocerebrosidase (<i>GBA</i>) gene have been reported to modify risk for Parkinson disease (PD) and dementia with Lewy bodies (DLB). However, these findings not consistently replicated, most studies had substantial methodological shortcomings. <h3>Objective</h3> To better assess role of<i>GBA</i>variants altering body disorders. <h3>Design</h3> Case-control study. <h3>Setting</h3> Four movement disorder clinics Seattle, Washington, area....
<h3>Background</h3> A functional repeat polymorphism in the<i>SNCA</i>promoter (<i>REP1</i>) conveys susceptibility for Parkinson disease (PD). There is also increasing evidence that single-nucleotide polymorphisms (SNPs) elsewhere the gene are associated with PD risk. <h3>Objectives</h3> To further explore association of common<i>SNCA</i>SNPs susceptibility, to determine whether allelic heterogeneity exists, and examine correlation between PD-associated variants plasma α-synuclein levels....