A5027460018- Genetic Associations and Epidemiology
- Schizophrenia research and treatment
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Genomic variations and chromosomal abnormalities
- Functional Brain Connectivity Studies
- Neuroscience and Music Perception
- Autism Spectrum Disorder Research
- Genomics and Rare Diseases
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Genetics and Neurodevelopmental Disorders
- Obsessive-Compulsive Spectrum Disorders
- Bioinformatics and Genomic Networks
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Congenital heart defects research
- Epigenetics and DNA Methylation
- Neurological disorders and treatments
- Smoking Behavior and Cessation
- Attention Deficit Hyperactivity Disorder
- Mental Health and Psychiatry
- Diet and metabolism studies
University of Colorado Denver
2013-2024
VA Eastern Colorado Health Care System
2019-2023
Broad Institute
2023
The University of Queensland
2021
Max Planck Institute of Psychiatry
2021
University of Colorado Anschutz Medical Campus
1999-2020
Denver VA Medical Center
1999-2019
Colorado School of Public Health
2019
University of Colorado System
2018
University of Colorado Health
2003-2016
Inheritance of a defect in neuronal mechanism that regulates response to auditory stimuli was studied nine families with multiple cases schizophrenia. The defect, decrease the normal inhibition P50 auditory-evoked second paired stimuli, is associated attentional disturbances Decreased occurs not only most schizophrenics, but also many their nonschizophrenic relatives, distribution consistent inherited vulnerability for illness. Neurobiological investigations both humans and animal models...
<h3>Context</h3> The α7 nicotinic acetylcholine receptor gene,<i>CHRNA7</i>, is associated with genetic transmission of schizophrenia and related cognitive neurophysiological sensory gating deficits. Cognitive dysfunction responsible for significant psychosocial disability in schizophrenia. Nicotine, a low-potency agonist at the receptor, has some positive effects on neurocognitive deficits schizophrenia, which suggests that more effective activation might meaningfully enhance cognition...
<h3>Background</h3> The α7 neuronal nicotinic acetylcholine receptor subunit gene(<i>CHRNA7</i>) has been implicated as a candidate gene for schizophrenia, and an auditory sensory processing deficit found in the disease, by both genetic linkage at 15q14 biochemical data. expression of<i>CHRNA7</i>is reduced several brain regions schizophrenic subjects compared with control subjects. This study presents DNA sequence analysis of core promoter region for<i>CHRNA7</i>in <h3>Methods</h3>...
Objective: To evaluate previously reported associations of copy number variants (CNVs) with schizophrenia and to identify additional associations, the authors analyzed CNVs in Molecular Genetics Schizophrenia study (MGS) available data. Method: After quality control, MGS data for 3,945 subjects or schizoaffective disorder 3,611 screened comparison were analysis rare (<1% frequency). CNV detection thresholds chosen that maximized concordance 151 duplicate assays. Pointwise genewise analyses...
Objective: Nicotinic acetylcholine receptors are possible therapeutic targets for schizophrenia, as shown by neurobiological and molecular evidence deficiencies in expression of α 7 -nicotinic receptors. Patients’ heavy smoking suggests attempted self-medication through this mechanism. The agent 3-(2,4-dimethoxybenzylidene) anabaseine (DMXB-A) is a partial agonist can be taken orally. A phase 1 trial showed cognitive enhancement schizophrenia. Method: Thirty-one subjects with schizophrenia...
Exploration of the genetic architecture specific endophenotypes may be a powerful strategy for understanding basis schizophrenia.To characterize some key endophenotypic measures selected their reported heritabilities in schizophrenia.Family-based heritability study.Seven sites across United States.At time these initial data analyses, members 183 nuclear families ascertained through probands with schizophrenia had been assessed endophenotypes.Variance component models were used to assess and...
Objective: The authors carried out a genetic association study of 14 schizophrenia candidate genes ( RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT , and ARVCF ). This tested the hypothesis with common single nucleotide polymorphisms (SNPs) in these using largest sample to date that has been collected uniform clinical methods most comprehensive set SNPs each gene. Method: included 1,870 cases (schizophrenia schizoaffective disorder) 2,002 screened...
The authors used a custom array of 1,536 single-nucleotide polymorphisms (SNPs) to interrogate 94 functionally relevant candidate genes for schizophrenia and identify associations with 12 heritable neurophysiological neurocognitive endophenotypes in data collected by the Consortium on Genetics Schizophrenia.
Sensory gating deficits found in schizophrenia can be assessed by using a paired auditory stimulus paradigm to measure evoked response. The ratio of the P50 response amplitude second or test that first conditioning is expressed as percentage. Normal subjects generally suppress and typically have ratios less than 40%. Subjects with half their first-degree relatives sensory gating, are greater 50%. Treatment typical neuroleptics does not reverse this deficit. However, previous studies shown...
The Consortium on the Genetics of Schizophrenia (COGS) is an ongoing, National Institute Mental Health-funded, 7-site collaboration investigating occurrence and genetic architecture quantitative endophenotypes related to schizophrenia. purpose this article provide a description COGS structure methods, including participant recruitment assessment.
Identification of biomarkers for cognitive dysfunction in schizophrenia is a priority psychiatry research. Functional imaging studies suggest that intrinsic "resting state" hippocampal hyperactivity characteristic feature schizophrenia. The relationships between this phenotype and symptoms the illness, however, are largely unexplored. authors examined resting activity patients healthy comparison subjects analyzed relationship function as measured by MATRICS Consensus Cognitive Battery (MCCB).
Multiple sources of evidence suggest that genetic factors influence variation in clinical features schizophrenia. The authors present the first genome-wide association study (GWAS) dimensional symptom scores among individuals with Based on Lifetime Dimensions Psychosis Scale ratings 2,454 case subjects European ancestry from Molecular Genetics Schizophrenia (MGS) sample, three (positive, negative/disorganized, and mood) were identified exploratory factor analysis. Quantitative for each a...
Objective The Consortium on the Genetics of Schizophrenia has undertaken a large multisite study to characterize 12 neurophysiological and neurocognitive endophenotypic measures as step toward understanding complex genetic basis schizophrenia. authors previously demonstrated heritability these endophenotypes; in present study, linkage was evaluated. Method Each family consisted proband with schizophrenia, at least one unaffected sibling, both parents. A total 1,286 participants from 296...
OBJECTIVE: People with schizophrenia, schizoaffective disorder, and bipolar illness share clinical symptoms, biological findings, genetic susceptibility. Diminished suppression of the P50 auditory evoked potential is a phenotype used in studies susceptibility schizophrenia. In patients acute mania, this inhibitory deficit has been correlated severity symptoms. This study addresses whether diminished represents associated psychosis illness. METHOD: The response to paired stimuli was measured...