A5049977124- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Neural and Behavioral Psychology Studies
- Alzheimer's disease research and treatments
- Traumatic Brain Injury Research
- Cardiovascular Health and Disease Prevention
- Face Recognition and Perception
- Traumatic Brain Injury and Neurovascular Disturbances
- EEG and Brain-Computer Interfaces
- Cardiac Imaging and Diagnostics
- Tensor decomposition and applications
- Neurobiology of Language and Bilingualism
- MRI in cancer diagnosis
- Nanoparticle-Based Drug Delivery
- Brain Tumor Detection and Classification
- Visual perception and processing mechanisms
- Stuttering Research and Treatment
- Glycosylation and Glycoproteins Research
- Visual Attention and Saliency Detection
- Advanced NMR Techniques and Applications
- Acute Ischemic Stroke Management
Michigan State University
2015-2024
Michigan United
2011-2024
Albert Einstein College of Medicine
2024
Resonance Research (United States)
2024
University Radiology
2012-2020
King's College Hospital
2020
University of Sheffield
2020
Gibson Institute of Cognitive Research
2020
Beth Israel Deaconess Medical Center
2017
Harvard University
2017
Biomarkers are needed to assist in the diagnosis and medical management of various neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's (PD), dementia with Lewy body (DLB). We have employed a multiplex quantitative
Within cancer, there is a large wealth of diversity, complexity, and information that nature has engineered rendering it challenging to identify reliable detection methods. Therefore, the development simple effective techniques delineate fine characteristics cancer cells can have great potential impacts on diagnosis treatment. Herein, we report magnetic glyco-nanoparticle (MGNP) based nanosensor system bearing carbohydrates as ligands, not only detect differentiate but also quantitatively...
Lewy body (LB) inclusions are one of the pathological hallmarks Parkinson's disease (PD) and dementia with bodies (DLB). One way to better understand process leading LB formation associated pathogenesis responsible for neurodegeneration in PD DLB is examine content inclusions. Here, we performed a proteomic investigation cortical LBs, obtained by laser capture microdissection from neurons temporal cortex patients disease. Analysis over 2500 LBs discovered 296 proteins; those, 17 had been...
To compare the diagnostic performances of three T1-weighted 3.0-T magnetic resonance (MR) sequences at carotid intraplaque hemorrhage (IPH) imaging, with histo logic analysis as reference standard.Institutional review board approval and informed consent were obtained for this HIPAA-compliant study. Twenty patients scheduled endarterectomy underwent MR including two-dimensional fast spin-echo, three-dimensional time-of-flight (TOF), magnetization-prepared rapid acquisition gradient-echo...
Affecting 1% of the general population, stuttering impairs normally effortless process speech production, which requires precise coordination sequential movement occurring among articulatory, respiratory, and resonance systems, all within millisecond time scales. Those afflicted experience frequent disfluencies during ongoing speech, often leading to negative psychosocial consequences. The aetiology remains unclear; compared other neurodevelopmental disorders, few studies date have examined...
Imaging and targeted delivery to macrophages are promising new approaches study treat a variety of inflammatory diseases such as atherosclerosis. In this manuscript, we have designed synthesized iron oxide based magnetic nanoparticles bearing hyaluronic acid (HA) on the surface target activated macrophages. The HA-coated were prepared through co-precipitation procedure followed by postsynthetic functionalization with HA fluorescein. characterized transmission electron microscopy,...
Advances in magnetic resonance (MR) imaging techniques enable the accurate measurements of cerebrospinal fluid (CSF) flow human brain. In addition, image reconstruction tools facilitate collection patient-specific brain geometry data such as exact dimensions ventricular and subarachnoidal spaces (SAS) well computer-aided CSF-filled spaces. The solution conservation CSF mass momentum balances over a finite computational mesh obtained from MR images predict patients' pressure field. Advanced...
Current diagnosis and monitoring of sports-related concussion rely on clinical signs symptoms, balance, vestibular, neuropsychological examinations. Conventional brain imaging often does not reveal abnormalities. We sought to assess if the longitudinal change functional structural connectivity default-mode network (DMN) can serve as a potential biomarker. Eight concussed Division I collegiate football student-athletes in season (one participated twice) 11 control subjects this study. ImPACT...
The cumulative effect of repetitive subconcussive collisions on the structural and functional integrity brain remains largely unknown. Athletes in collision sports, like football, experience a large number impacts across single season play. majority these impacts, however, are generally overlooked, their long-term consequences remain poorly understood. This study sought to examine effects competitive NCAA Football Bowl Subdivision athletes using advanced neuroimaging approaches. Players were...
The ability to express thoughts through fluent speech production is a most human faculty, one that often taken for granted. Stuttering, which disrupts the smooth flow of speech, affects 5% preschool-age children and 1% general population, can lead significant communication difficulties negative psychosocial consequences throughout one's lifetime. Despite fact symptom onset typically occurs during early childhood, few studies have yet examined possible neural bases developmental stuttering...
Currently, there is high interest in developing multifunctional theranostic platforms for cancer monitoring and chemotherapy. Herein, we report hyaluronan (HA)-coated superparamagnetic iron oxide nanoparticles (HA-SPION) as a promising system targeted imaging drug delivery. When incubated with cells, HA-SPIONs were rapidly taken up the internalization of HA-SPION by cells was much higher than NPs without HA coating. The magnetic relaxivity coupled enhanced uptake enabled resonance cells....
Disturbances of the cerebrospinal fluid (CSF) flow in brain can lead to hydrocephalus, a condition affecting thousands people annually US. Considerable controversy exists about and pressure dynamics, how responds changes patterns compression hydrocephalus. This paper presents new model based on first principles mechanics. fluid-structure interactions predicts flows pressures throughout brain's ventricular pathways consistent with both animal intracranial (ICP) measurements human CINE...
Abstract Social stimuli function as emotional barometers for the immediate environment are catalysts many reactions, and have inherent value relationships survival independent of their current content. We, therefore, propose that neural mechanisms underlying social information processing may be interconnected. In study, we examined interactive effects processes on brain activation. Whole-brain images were acquired while participants viewed categorized affective pictures varied two...
Abstract The urgent need to recognize danger quickly has been shown rely on preferential processing in dedicated neural circuitry. In previous behavioral studies examining the pattern of face when displaying anger, we found evidence that simple noncontextual geometric shapes containing downward-pointing V-shaped angles activate perception threat. We here report circuitry known be mobilized by many realistic, contextual threatening displays is also triggered simplest form this movement...
Human can flexibly attend to a variety of stimulus dimensions, including spatial location and various features such as color direction motion. Although the locus attention has been hypothesized be represented by priority maps encoded in several dorsal frontal parietal areas, it is unknown how brain represents attended features. Here we examined distribution organization neural signals related deployment feature-based attention. Subjects viewed compound containing two superimposed motion...
We applied a multi-modal imaging approach to examine structural and functional alterations in the default-mode network (DMN) that are associated with Alzheimer's disease (AD) amnestic mild cognitive impairment (aMCI), transitional phase between
Intrathecal drug delivery is an efficient method to administer therapeutic molecules the central nervous system. However, even with identical dosage and administration mode, extent of distribution in vivo highly variable difficult control. Different cerebrospinal fluid (CSF) pulsatility from patient may lead different distribution. Medical image-based computational dynamics (miCFD) used construct a patient-specific model quantify transport as function spectrum physiological CSF...
This prospective controlled observational cohort study assessed the performance of a novel panel serum microRNA (miRNA) biomarkers on indicators concussion, subconcussive impacts, and neurocognitive function in collegiate football players over playing season. Male student athletes participating Division I Football Bowl Subdivision National Collegiate Athletic Association (NCAA) were enrolled. There total 53 participants included study, 30 non-athlete control subjects 23 male athletes....
Biomarkers are pressingly needed to assist with the clinical diagnosis of neurodegenerative diseases and/or monitoring disease progression. Glycoproteins enriched in bodily fluids such as human cerebrospinal fluid (CSF), an ideal source for discovering biomarkers due its proximity central nervous system (CNS), and consequently can serve diagnostic therapeutic markers CNS diseases. We report here in-depth identification glycoproteins CSF using a complementary proteomic approach which...