A5100318325- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Synthesis and biological activity
- Click Chemistry and Applications
- Cancer Treatment and Pharmacology
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Vitamin D Research Studies
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Quantum Chromodynamics and Particle Interactions
- Cell death mechanisms and regulation
- Computational Drug Discovery Methods
- Particle Detector Development and Performance
- Ubiquitin and proteasome pathways
Chinese Academy of Sciences
2016-2025
Zhongshan Hospital
2015-2025
Fudan University
2011-2025
Yangzhou University
2014-2025
Shanghai Institute of Materia Medica
2018-2025
Harvard University
1997-2025
First Affiliated Hospital of Xiamen University
2013-2025
First Bethune Hospital of Jilin University
2008-2025
Oil and Gas Research Institute
2025
Northeast Petroleum University
2019-2025
Olaparib is an oral poly(adenosine diphosphate–ribose) polymerase inhibitor that has promising antitumor activity in patients with metastatic breast cancer and a germline BRCA mutation.
Among breast cancers without human epidermal growth factor receptor 2 (HER2) amplification, overexpression, or both, a large proportion express low levels of HER2 that may be targetable. Currently available HER2-directed therapies have been ineffective in patients with these "HER2-low" cancers.
Partial or even complete cancer regression can be achieved in some patients with current treatments. However, such initial responses are almost always followed by relapse, the recurrent being resistant to further The discovery of therapeutic approaches that counteract relapse is, therefore, essential for advancing medicine. Cancer cells extremely heterogeneous, each individual patient, terms their malignant potential, drug sensitivity, and potential metastasize cause relapse. Indeed,...
Adaptation to hypoxia is mediated through a coordinated transcriptional response driven largely by hypoxia-inducible factor 1 (HIF-1). We used ChIP-chip and gene expression profiling identify direct targets of HIF-1 transactivation on genome-wide scale. Several hundred were identified and, as expected, highly enriched for proteins that facilitate metabolic adaptation hypoxia. Surprisingly, there was also striking enrichment the family 2-oxoglutarate dioxygenases, including jumonji-domain...
β-Amyloid (Aβ) peptides are thought to be critically involved in the etiology of Alzheimer's disease (AD). The aspartyl protease β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is required for production Aβ, and BACE1 inhibition thus an attractive target treatment AD. We show that verubecestat (MK-8931) a potent, selective, structurally unique inhibitor reduced plasma, cerebrospinal fluid (CSF), brain concentrations Aβ40, Aβ42, sAPPβ (a direct product enzymatic activity) after...
G protein-coupled receptors (GPCRs) are classically characterized as cell-surface transmitting extracellular signals into cells. Here we show that central components of a GPCR signaling system comprised the melatonin type 1 receptor (MT
A growing number of orphan G-protein-coupled receptors (GPCRs) have been reported to be activated by lipid ligands, such as lysophosphatidic acid, sphingosine 1-phosphate (S1P), and cannabinoids, for which there are already well established receptors. These new ligand claims controversial due either lack independent confirmations or conflicting reports. We used the beta-arrestin PathHunter assay system, a newly developed, generic GPCR format that measures binding GPCRs, evaluate receptor...
Pyrotinib, an irreversible pan-ErbB inhibitor, showed promising antitumor activity and acceptable tolerability in a phase I trial. We assessed the efficacy of pyrotinib versus lapatinib, both combination with capecitabine, women human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer open-label, multicenter, randomized II study.Chinese patients HER2-positive relapsed or previously treated taxanes, anthracyclines, and/or trastuzumab were assigned (1:1) to receive 400...
Mycobacterium leprae causes leprosy. M strains collected worldwide have been genetically clonal, which poorly explains the varying severity and clinical features of disease. We discovered a new species from 2 patients who died diffuse lepromatous leprosy (DLL). The was purified heavily infected, freshly frozen autopsy liver tissue followed by DNA extraction in 1 case. Paraffin-embedded skin used for another Six genes organism were amplified polymerase chain reaction, sequenced on cloning or...
The first highly enantioselective hydrogenation of simple indoles was developed with a Brønsted acid as an activator to form the iminium intermediate in situ, which hydrogenated using Pd(OCOCF3)2/(R)-H8-BINAP catalyst system up 96% ee. present method provides efficient route enantioenriched 2-substituted and 2,3-disubstituted indolines.
Aberrant activation of Bruton's tyrosine kinase (BTK) plays an important role in pathogenesis B-cell lymphomas, suggesting that inhibition BTK is useful the treatment hematological malignancies. The discovery a more selective on-target covalent inhibitor high value. Herein, we disclose and preclinical characterization potent, selective, irreversible as our clinical candidate by using vitro potency, selectivity, pharmacokinetics (PK), vivo pharmacodynamic for prioritizing compounds. Compound...