A5007402637- Soil Carbon and Nitrogen Dynamics
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Soil erosion and sediment transport
- Soil and Unsaturated Flow
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Mathematical and Theoretical Epidemiology and Ecology Models
- Microwave Engineering and Waveguides
- MXene and MAX Phase Materials
- Environmental Quality and Pollution
- Virus-based gene therapy research
- Evolution and Genetic Dynamics
- 2D Materials and Applications
- Housing Market and Economics
- Viral Infectious Diseases and Gene Expression in Insects
- Electromagnetic Scattering and Analysis
- Vector-Borne Animal Diseases
- Electromagnetic Simulation and Numerical Methods
- Soil Geostatistics and Mapping
- Local Government Finance and Decentralization
- Dendrimers and Hyperbranched Polymers
- Neutropenia and Cancer Infections
Lanzhou Veterinary Research Institute
2019-2025
Chinese Academy of Agricultural Sciences
2019-2025
Lanzhou University
2024-2025
Tiangong University
2024
BeiGene (China)
2019-2024
Hunan Agricultural University
2012-2023
Zhejiang University
2021
Augusta University
2013-2019
Chinese Academy of Sciences
2009-2017
Lanzhou Institute of Chemical Physics
2016-2017
Aberrant activation of Bruton's tyrosine kinase (BTK) plays an important role in pathogenesis B-cell lymphomas, suggesting that inhibition BTK is useful the treatment hematological malignancies. The discovery a more selective on-target covalent inhibitor high value. Herein, we disclose and preclinical characterization potent, selective, irreversible as our clinical candidate by using vitro potency, selectivity, pharmacokinetics (PK), vivo pharmacodynamic for prioritizing compounds. Compound...
Abstract Venetoclax, the first-generation inhibitor of apoptosis regulator B-cell lymphoma 2 (BCL2), disrupts interaction between BCL2 and proapoptotic proteins, promoting in malignant cells. Venetoclax is mainstay therapy for relapsed chronic lymphocytic leukemia under investigation multiple clinical trials treatment various cancers. Although venetoclax can result high rates durable remission, relapse has been widely observed, indicating emergence drug resistance. The G101V mutation...
Programmed cell death protein 1 (PD-1), an immune checkpoint receptor expressed by activated T, B, and NK cells, is a well-known target for cancer immunotherapy. Tislelizumab (BGB-A317) anti-PD-1 antibody that has recently been approved treatment of Hodgkin's lymphoma urothelial carcinoma. Here, we show tislelizumab displayed remarkable antitumor efficacy in B16F10/GM-CSF mouse model. Structural biology Surface plasmon resonance (SPR) analyses revealed unique epitopes tislelizumab,...
The vascularization of tissue-engineered bone is a prerequisite step for the successful repair defects.Hypoxia inducible factor-1α (HIF-1α) plays an essential role in angiogenesis-osteogenesis coupling during regeneration and can activate expression angiogenic factors mesenchymal stem cells (MSCs).Dimethyloxaloylglycine (DMOG) small molecule that inhibit prolyl hydroxylase (PHD) enzymes thus regulate stability HIF-1α at normal oxygen tension.Human induced pluripotent cell-derived MSCs...
ABSTRACT Neutralizing antibodies provide vital protection against foot-and-mouth disease virus (FMDV). The neutralization test (VNT) is a gold standard method for the detection of neutralizing antibodies. However, its application limited due to requirement live and unsuitability large-scale serological surveillance. In this study, porcine broadly monoclonal antibody (PO18-10) FMDV was obtained from heterologous sequentially vaccinated pig using single-B-cell technology. A competitive...
<title>Abstract</title> Recently, serotype O FMDVs belonging to four lineages (O/ME-SA/PanAsia, O/ME-SA/Ind2001, O/SEA/Mya-98 and O/Cathay) co-circulate in China the incursion of new variant virus Cathay lineage renders existing vaccines less effective, which poses a serious threat livestock industries. The surface-exposed G-H loop VP1 structural protein FMDV plays important roles for inducing neutralizing antibodies, generation antigenic attachment. Here, we generated three recombinant...
This work presented a feasible strategy to generate molybdenum disulfide (MoS<sub>2</sub>) nanosheets by direct liquid shear exfoliation technique in green mixed solvent system of ethanol/water.
Immunization with effective cancer vaccines can offer a much needed adjuvant therapy to fill the treatment gap after liver resection prevent relapse of hepatocellular carcinoma (HCC). However, current HCC are mostly based on native shared-self/tumor antigens that only able induce weak immune responses. In this study we investigated whether HCC-associated self/tumor antigen alpha-fetoprotein (AFP) could be engineered create an vaccine break tolerance and potently activate CD8 T cells...
It is a great challenge to isolate the broadly neutralizing antibodies (bnAbs) against foot-and-mouth disease virus (FMDV) due its existence as seven distinct serotypes without cross-protection. Here, by vaccination of pig with FMDV O and A whole antigens, we obtained 10 bnAbs O, and/or Asia1 dissecting 216 common clonotypes two specific porcine B-cell receptor (BCR) gene repertoires containing total 12720 B cell clones, indicating induction cross-serotype after sequential antigens. The...
Abstract To understand why vaccine-activated tumor-specific T cells often fail to generate antitumor effects, we studied two α-fetoprotein–specific CD8+ (Tet499 and Tet212) that had different effects. We found Tet499 required high antigen doses for reactivation, but could survive persistent stimulation maintain their effector functions. In contrast, Tet212 a low threshold of underwent exhaustion apoptosis in the presence antigen. vivo, expanded more than upon reencountering generated...
The sequence variation within the capsid proteins occurs frequently in infection of susceptible tissue cultures, reflecting high levels genetic diversity FMDV. A systematic study for functional significance isolate-specific residues VP0 and VP3 FMDV PanAsia-1 strains suggested that interaction amino acid side chains between N terminus VP4 several potential domains VP1-3 had cascading effects on viability developmental characteristics progeny viruses. Y2079H indicated FMDVs could affect...
Abstract Identification of the dominant factors controlling rice ( Oryza sativa L.) yield is paramount importance to improve fertilizer use efficiency, effectively promote productivity, and help ensure food security. The objective this study was quantify influence geographic attributes, soil properties, climatic, types on annual identify control in southern China. In total, 2010 samples were collected selected areas analyzed for 34 that potentially influenced yield. Because these exhibit...
Foot-and-mouth disease virus (FMDV) is a highly contagious that infects cloven-hoofed animals. Neutralizing antibodies play critical roles in antiviral infection. Although five known antigen sites induce neutralizing have been defined, studies on cross-protective are still scarce. We mapped two using 13 bovine-derived broadly monoclonal (bnAbs) capable of 4 lineages within 3 topotypes FMDV serotype O. One site was formed by novel cluster VP3-focused epitopes recognized bnAb C4 and C4-like...
Abstract Understanding regional spatial pattern of soil organic carbon density (SOCD) and its potential influencing factors in cropland is paramount importance when evaluating quality assess the sequestration potential. However, little information available regarding SOCD for plough layer soils with high‐density sampling sites. In this context, 14,058 samples were collected at a scale (21 × 10 4 km 2 ) to investigate variation identify dominant using classical statistics, principal component...
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