A5045973787- Vector-borne infectious diseases
- Insect and Pesticide Research
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Vectors
- Cancer Research and Treatments
- Cardiac Fibrosis and Remodeling
- Heat shock proteins research
- Cancer-related Molecular Pathways
- Insect symbiosis and bacterial influences
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Chronic Lymphocytic Leukemia Research
- Inflammatory Biomarkers in Disease Prognosis
- Graphene and Nanomaterials Applications
- Angiogenesis and VEGF in Cancer
- Drug Solubulity and Delivery Systems
- Cell death mechanisms and regulation
- Intracerebral and Subarachnoid Hemorrhage Research
- Research on Leishmaniasis Studies
- Prosthetics and Rehabilitation Robotics
- Pregnancy and Medication Impact
- Ammonia Synthesis and Nitrogen Reduction
- Adsorption and biosorption for pollutant removal
Yan'an University
2024
Hebei Normal University
2005-2024
BeiGene (China)
2019-2024
University of Toronto
2023
Nanjing Tech University
2020-2021
Queen's University
2018-2021
Yangpu Hospital of Tongji University
2019
Tianjin University of Science and Technology
2014-2018
Huaibei Normal University
2008
Abstract Venetoclax, the first-generation inhibitor of apoptosis regulator B-cell lymphoma 2 (BCL2), disrupts interaction between BCL2 and proapoptotic proteins, promoting in malignant cells. Venetoclax is mainstay therapy for relapsed chronic lymphocytic leukemia under investigation multiple clinical trials treatment various cancers. Although venetoclax can result high rates durable remission, relapse has been widely observed, indicating emergence drug resistance. The G101V mutation...
Exosomal PD-L1 (exoPD-L1) has recently received significant attention as a biomarker predicting immunotherapeutic responses involving the PD1/PD-L1 pathway. However, current technologies for exosomal analysis rely primarily on bulk measurements that do not consider heterogeneity found within subpopulations. Here, we present nanoscale cytometry platform NanoEPIC, enabling phenotypic sorting and exoPD-L1 profiling from blood plasma. We highlight efficacy of NanoEPIC in monitoring anti-PD-1...
High-quality sPS aerogels with varying contents and molecular weights were prepared by direct freeze-drying of p -xylene-based gels.
Ticks are notorious blood-sucking arthropods that can spread a variety of pathogens and cause great harm to the health humans, wildlife domestic animals. The salivary glands female ticks degenerate rapidly when reach critical weight or become engorged, which be caused by hormones synergistic effects multiple proteins. To explore complex molecular mechanisms gland degeneration in ticks, this study applies iTRAQ quantitative proteomic technology for first time changes protein expression...
Docetaxel (DTX), as a first-line anti-tumor drug, has been studied for decades its diverse bioactivities. However, DTX presents poor solubility in water, low bioavailability and serious toxic side effects which hindered application the clinic. To address these problems, docetaxel-sulfobutyl ether-β-cyclodextrin inclusion complex (DTX-SBE-β-CD) was prepared successfully by saturated aqueous solution method. Sulfobutyl ether β-cyclodetrin (SBE-β-CD) is used delivery material. For this study,...
Cancer, also known as a malignant tumor, has developed into type of disease with the highest fatality rate, seriously threatening lives and health people. Chemotherapy is one most important methods for treatment cancer. However, chemotherapy drugs have some problems, such low solubility lack targeting, which severely limit their clinical applications. To solve these we designed block copolymer that disulfide bond response. The polymer uses RGD peptide (arginine-glycine-aspartic acid) active...
Cerebral small vessel disease (CSVD) is a major cause of stroke, particularly in the elderly population, leading to significant morbidity and mortality. Accurate identification high-risk patients timing stroke occurrence plays crucial role patient prevention treatment. The study aimed establish validate risk stratification model for within three years with CSVD using combined MRI machine learning algorithm approach.
The simple and functional modification of the nanoparticle's surface is used to efficiently deliver chemotherapeutic drugs for anti-cancer treatment. Here, we construct a nanocrystalline drug delivery system with doxorubicin wrapped in red blood cell membranes treatment mouse breast cancer models. Compared traditional free treatments, biodegradable natural membrane combined pure crystalline drugs. nanoparticles obtained by preparation method have superior properties, such as good stability,...
As obligate blood-feeding ectoparasites, ticks secrete a great diversity of antithrombin molecules during feeding. In this study, novel gene named Doenitin-1 was characterized from the tick Haemaphysalis doenitzi. It has an open reading frame size 426 bp; it encodes 141 amino acids and predicted molecular weight 15.8 kDa. The fibrinogen coagulation test showed that time increased significantly with increase in rDoenitin-1 protein concentration, activated partial thromboplastin (APTT)...
The tick Dermacentor silvarum is recognized as an emerging vector of marked medical and veterinary significance. current study investigated the gene expression profiling unfed nymphal D. in response to low temperature using high-throughput transcriptome sequencing. A total approximately 12-giga base pairs were produced, which yielded 87,500 unigenes, among them, 29,815 unigenes successfully annotated by all available databases (NCBI nonredundant, Swissprot, UniProtKB/TrEMBL, clusters...
Myocardin plays a key role in the development of cardiac hypertrophy. However, upstream signals that control stability and transactivity myocardin remain to be fully understood. The expression protein kinase Cα (PKCα) also induces An essential downstream molecule PKCα, extracellular signal-regulated 1/2, was reported negatively regulate activities myocardin. But, effect cooperation between PKCα potential molecular mechanism by which regulates myocardin-mediated hypertrophy are unclear. In...
The discovery and development of immuno-oncology (I-O) therapy in recent years represents a milestone the treatment cancer. However, challenges persist. Robust disease-relevant animal models are vital resources for continued preclinical research order to address range additional immune checkpoints. Here, we describe human peripheral blood mononuclear cell (PBMC) - based humanized xenograft model. BGB-A317 (Tislelizumab), an investigational anti-PD-1 antibody late-stage clinical development,...
Abstract Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes capable phosphorylating phosphatidylinositol to phosphoinositides, which important secondary messengers involved in various cell signaling and functions. PI3Kδ is one four isoforms (PI3Kα, β, δ γ) the PI3K class I family. It restrictively expressed leukocytes. key signal transduction component for normal malignant B cells also homeostasis function T-regulatory (Treg), making it promising target treatment both hematologic...
The discovery and development of immuno-oncology (I-O) therapy in recent years represents a milestone the treatment cancer. However, challenges persist. Robust disease-relevant animal models are vital resources for continued preclinical research order to address range additional immune checkpoints. Here, we describe human peripheral blood mononuclear cell (PBMC) — based humanized xenograft model. BGB-A317 (Tislelizumab), an investigational anti-PD-1 antibody late-stage clinical development,...
Abstract The main cause of cancer-associated deaths is the spread cancer cells to distant organ sites. Despite recent advances in treating primary tumors, modern chemotherapeutic strategies are relatively ineffective at metastasis, with clinical trials showing minimal improvements overall survival for patients metastatic disease. This large part due chemotherapy resistance which remains a major challenge limiting therapeutic responses patients. cytoskeleton crosslinker protein ezrin has been...
In order to enhance the adsorption property of adsorbent, surface modification existing materials has always been an interesting and challenging topic. Herein, flower-like MnO2 nanowires (MNs) with three dimensions area great was successfully prepared by two-step hydrothermal route via nanosheets in-situ growth on nanowires. As MNs evaluated for removal methylene blue (MB) from aqueous solution. The effect pH value, contact time, adsorbent dose, equilibrium, kinetics process, isothermal...