A5100765139- Pharmaceutical and Antibiotic Environmental Impacts
- Crystallization and Solubility Studies
- RNA and protein synthesis mechanisms
- X-ray Diffraction in Crystallography
- Antibiotic Resistance in Bacteria
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Tuberculosis Research and Epidemiology
- Atmospheric chemistry and aerosols
- Reproductive Biology and Fertility
- DNA and Nucleic Acid Chemistry
- Genomics and Chromatin Dynamics
- Antimicrobial Resistance in Staphylococcus
- Optical Imaging and Spectroscopy Techniques
- Air Quality and Health Impacts
- Reproductive Health and Technologies
- Vibrio bacteria research studies
- Cancer therapeutics and mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ovarian function and disorders
- Antibiotics Pharmacokinetics and Efficacy
- Nuts composition and effects
- Gastrointestinal Tumor Research and Treatment
Institute of Soil Science
2018-2024
Chinese Academy of Sciences
2014-2024
University of Chinese Academy of Sciences
2009-2024
University of Michigan
2018-2024
Liaoning Academy of Agricultural Sciences
2023-2024
BeiGene (China)
2024
Institute of Atmospheric Physics
2021-2023
Michigan Medicine
2022
Hubei Academy of Agricultural Sciences
2020-2022
Center for Excellence in Brain Science and Intelligence Technology
2022
Abstract Venetoclax, the first-generation inhibitor of apoptosis regulator B-cell lymphoma 2 (BCL2), disrupts interaction between BCL2 and proapoptotic proteins, promoting in malignant cells. Venetoclax is mainstay therapy for relapsed chronic lymphocytic leukemia under investigation multiple clinical trials treatment various cancers. Although venetoclax can result high rates durable remission, relapse has been widely observed, indicating emergence drug resistance. The G101V mutation...
Different fertilization and cropping systems may influence short- long-term residues of antibiotic resistance genes (ARGs) mobile genetic elements (MGEs) in soil. Soils from dryland (peanut) paddy (rice) fields, which originated the same nonagricultural land (forested), were treated with either chemical fertilizer, composted manure, or no fertilizer for 26 years before sampling, occurred one year after last applications. ARGs MGEs investigated using highly parallel qPCR high-throughput...
The effect of manure application on the distribution and accumulation antibiotic resistance genes (ARGs) in tissue root vegetables remains unclear, which poses a bottleneck assessing health risks from due to manure. Towards this goal, experiments were conducted pots investigate bioaccumulation ARGs carrot tissues pig 144 targeting nine types antibiotics quantified by high throughput qPCR soil plant samples. rhizosphere was hot spot for enrichment manured soil. abundance, diversity, factors...
The proliferation and spread of antibiotic resistance genes (ARGs) is becoming a worldwide crisis. Extracellular DNA encoding ARGs (eARGs) in aquatic environment plays critical role the dispersion antimicrobial genes. Strategies to control dissemination eARGs are urgently required for ecological safety human health. Towards this goal, magnetic biochar/quaternary phosphonium salt (MBQ), was used investigate efficiency removal mechanism eARGs. Magnetic biochar modified by quaternary enhanced...
Cellular DNA lesions are efficiently countered by repair in conjunction with delays cell cycle progression. Previous studies have demonstrated that Rad9, Hus1, and Rad1 can form a heterotrimeric complex (the 9-1-1 complex) plays dual roles checkpoint activation eukaryotic cells. Although the has been proposed to toroidal structure similar proliferating nuclear antigen (PCNA), which essential replication repair, structural basis it performs different functions not elucidated. Here we report...
As a molecular imaging technique, bioluminescence tomography (BLT) with its highly sensitive detection and facile operation can significantly reveal cellular information in vivo at the whole-body small animal level. However, because of complex photon transportation biological tissue boundary data high noise, bioluminescent sources deeper positions generally cannot be localized. In our previous work, we used achromatic or monochromatic measurements an priori permissible source region strategy...
Compared with the ever-growing information about anthropogenic discharge of nutrients, metals, and antibiotics on disturbance antibiotic resistance genes (ARGs), less is known how potential natural stressors drive evolutionary processes resistance. This study examined soil resistomes evolved differentiated over 30 years in various land use settings spatiotemporal homogeneity minimal human impact. We found that contents organic carbon, nitrogen, microbial biomass, bioavailable heavy as well...
As an important small animal imaging technique, optical has attracted increasing attention in recent years. However, the photon propagation process is extremely complicated for highly scattering property of biological tissue. Furthermore, light transport simulation tissue a significant influence on inverse source reconstruction. In this contribution, we present two Galerkin-based meshless methods (GBMM) to determine exitance surface diffusive The are both based moving least squares (MLS)...
YfiBNR is a recently identified bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) signaling system in opportunistic pathogens. It key regulator of biofilm formation, which correlated with prolonged persistence infection and antibiotic drug resistance. In response to cell stress, YfiB the outer membrane can sequester periplasmic protein YfiR, releasing its inhibition YfiN on inner thus provoking diguanylate cyclase activity induce c-di-GMP production. However, detailed regulatory mechanism remains...
Indolmycin (IND) is a microbial natural product that selectively inhibits bacterial tryptophanyl-tRNA synthetase (TrpRS). The tryptophan biosynthesis pathway was recently shown to be an important target for developing new antibacterial agents against Mycobacterium tuberculosis (Mtb). We investigated the activity of IND several mycobacterial model strains. A TrpRS biochemical assay developed analyze library synthetic analogues. 4″-methylated compound, Y-13, showed improved anti-Mtb with...
The global spread and distribution of antibiotic resistance genes (ARGs) has received much attention whereas knowledge about the transmission ARGs from one matrix to another is still insufficient. In this study, paddy fields fertilized with chemical fertilizer, swine compost, no fertilizer were investigated assess transfer soil rice. Soil plant samples collected at day 0, 7, 30 79 representing various stages growth. High throughput qPCR was applied quantify using a set 144 primers. Gene copy...
Mycobacterium tuberculosis (Mtb) remains the deadliest pathogenic bacteria worldwide. The search for new antibiotics to treat drug-sensitive as well drug-resistant has become a priority. essential enzyme phenylalanyl-tRNA synthetase (PheRS) is an antibacterial drug target because of large differences between bacterial and human PheRS counterparts. In high-throughput screening 2148 bioactive compounds, PF-3845, which known inhibitor fatty acid amide hydrolase, was identified inhibiting Mtb at...
Abstract Evolution of resistance by pests reduces the benefits transgenic crops that produce insecticidal proteins from Bacillus thuringiensis (Bt). Here we analyzed to Bt toxin Cry1Ac in a field-derived strain pink bollworm ( Pectinophora gossypiella ), global pest cotton. We discovered r14 allele cadherin gene PgCad1 ) has 234-bp insertion exon 12 encoding mutant protein lacks 36 amino acids repeat 5 (CR5). A homozygous for this had 237-fold Cry1Ac, 1.8-fold cross-resistance Cry2Ab, and...
Abstract Cyclic diguanylate monophosphate (c-di-GMP) is a second messenger involved in bacterial signal transduction and produced by cyclases (DGCs) generally containing highly variable periplasmic signal-recognition domains. CdgH DGC enzyme that regulates rugosity associated phenotypes Vibrio cholerae . has two N-terminal tandem substrate-binding (PBPb) domains for its recognition; however, the role of PBPb remains unclear. Here, we reported crystal structure portion CdgH, which indicated...