A5106418141- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
- Energy, Environment, Economic Growth
- Plant Pathogens and Resistance
- Plant Disease Resistance and Genetics
- Cancer-related molecular mechanisms research
- Pulmonary Hypertension Research and Treatments
- Breast Cancer Treatment Studies
- Heart Failure Treatment and Management
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Function and Risk Factors
- Tryptophan and brain disorders
- RNA modifications and cancer
- Healthcare and Venom Research
- Circular RNAs in diseases
- Plant Molecular Biology Research
- Nitrogen and Sulfur Effects on Brassica
- Facial Nerve Paralysis Treatment and Research
- Fungal Biology and Applications
- Cancer, Lipids, and Metabolism
- Renal function and acid-base balance
- Reproductive System and Pregnancy
Zhengzhou University
2021-2025
Henan Cancer Hospital
2023-2025
Nanjing Tech University
2024
Zhejiang Wanli University
2023-2024
Shanxi Medical University
2024
BeiGene (China)
2024
Northwest University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Wangjing Hospital of China Academy of Chinese Medical Sciences
2024
Shandong University of Technology
2024
Abstract Venetoclax, the first-generation inhibitor of apoptosis regulator B-cell lymphoma 2 (BCL2), disrupts interaction between BCL2 and proapoptotic proteins, promoting in malignant cells. Venetoclax is mainstay therapy for relapsed chronic lymphocytic leukemia under investigation multiple clinical trials treatment various cancers. Although venetoclax can result high rates durable remission, relapse has been widely observed, indicating emergence drug resistance. The G101V mutation...
Due to the unique characteristics of breast cancer initiation sites and significant alterations in tumor metabolism, cells rely on lipid metabolic reprogramming effectively regulate programs during disease progression cascade.This adaptation enables them meet energy demands required for proliferation, invasion, metastasis, responses signaling molecules microenvironment.In this review, we comprehensively examined distinctive features elucidated underlying mechanisms driving aberrant behavior...
Responsive drug delivery nanocapsules based on poly(methacrylic acid)/carbon dots for sonodynamic/chemotherapy of tumors.
This study aims to identify suitable candidates for axillary sentinel lymph node biopsy (SLNB) or targeted dissection (TAD) among clinical N2 (cN2) triple-negative (TN) HER2 positive (HER2+）breast cancer patients following neoadjuvant therapy（NAT）.
Epstein-Barr virus (EBV) is a human tumor associated with variety of malignancies, including nasopharyngeal carcinoma, gastric cancers, and B-cell lymphomas. N6-methyladenosine (m6A) modifications modulate wide range cellular processes participate in the regulation virus-host cell interactions. Here, we discovered that EBV infection downregulates Toll-like receptor 9 (TLR9) m6A modification levels thus inhibits TLR9 expression. has multiple sites. Knockdown METTL3, an "writer", decreases...
For patients with breast cancer, the amplification of Human Epidermal Growth Factor 2 (HER2) is closely related to their prognosis and treatment decisions. This study aimed further improve accuracy efficiency HER2 status detection a deep learning model, apply model predict efficacy neoadjuvant therapy. We combined Next-Generation Sequencing (NGS) data IHC staining images 606 cancer developed Vision Transformer (ViT) identify through these images. was then applied therapy in 399 HER2-positive...
Although previous studies indicated that cumulus cells (CCs) accelerate oocyte aging by releasing soluble factors, the factors have yet to be characterized.While demonstrating CCs promoted Fas ligand (sFasL), our recent study suggested might secrete other mediate as well.This tested whether secreting tumor necrosis factor (TNF)-α.The results showed mouse undergoing apoptosis released TNF-α (sTNF-α) during in vitro aging.While ethanol activation rates were higher, maturation-promoting (MPF)...
According to the American Society of Clinical Oncology/College Pathologists (ASCO/CAP) criteria, both immunohistochemical HER2 (3+) and (2+)/in situ hybridization (ISH) amplified [HER2 (2+)/ISH+] breast cancers (BCs) fall under HER2-positive BC category. However, there is a lack studies exploring difference neoadjuvant therapeutic response between patients with (2+)/ISH+ early BC. We aimed evaluate response, long-term outcome, intrinsic subtype heterogeneity
Abstract Background Accurate assessment of axillary status after neoadjuvant therapy for breast cancer patients with lymph node metastasis is important the selection appropriate subsequent treatment decisions. Our objectives were to accurately predict whether metastases could achieve pathological complete response (pCR). Methods We collected imaging data extract longitudinal CT image features before and chemotherapy (NAC), analyzed correlation between radiomics clinicopathological features,...
We retrospectively reviewed a total of 257 stage I to IIIa lung adenocarcinoma after resection, tested them for the epidermal growth factor receptor (EGFR) mutation, and analyzed effect perioperative treatment on survival. The results showed that in patients with an EGFR adjuvant EGFR-tyrosine kinase inhibitor monotherapy complete resection significantly prolongs disease-free survival compared chemotherapy and/or radiotherapy.Adjuvant cisplatin-based improves non-small-cell cancer (NSCLC)...