A5021468450- Peroxisome Proliferator-Activated Receptors
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Marine Sponges and Natural Products
- Neuroscience and Neuropharmacology Research
- Reconstructive Facial Surgery Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Microbial Natural Products and Biosynthesis
- Selenium in Biological Systems
- Folate and B Vitamins Research
- Sperm and Testicular Function
- Alzheimer's disease research and treatments
- Computational Drug Discovery Methods
- Congenital Diaphragmatic Hernia Studies
- Reconstructive Surgery and Microvascular Techniques
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- NF-κB Signaling Pathways
- Eicosanoids and Hypertension Pharmacology
- Protein Hydrolysis and Bioactive Peptides
- Calcium signaling and nucleotide metabolism
Nanjing Medical University
2025
Capital Medical University
2020-2024
Yanbian University
2018-2024
Inner Mongolia Medical University
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Beijing Friendship Hospital
2021-2024
Xinjiang Medical University
2024
McGill University
2020-2024
First Affiliated Hospital of Xinjiang Medical University
2024
303 Hospital of People's Liberation Army
2023
Abstract Background Myocardial infarction (MI) is a major cause of mortality and morbidity worldwide. The intercellular communication in post-infarction angiogenesis remains unclear. Methods In this study, we explored the role mechanism action M2 macrophage-derived exosomes (M2-exos) after MI. M2-exos were harvested injected intramyocardially at onset Two distinct endothelial cells (ECs) cultured with to explore direct effects on angiogenesis. Results We showed that improved cardiac...
Abstract To investigate the determination of carbamazepine, oxazepine and their metabolites 10, 11-epoxy carbamazepine (CBZ), 11-dihydro10-hydroxyl (MHD) in blood by HPLC interfering factors. The samples were pretreated protein precipitation method. chromatographic conditions as follows: Agilent Eclipse Plus C18 column (4.6 mm × 250 mm, 5 μm); Mobile phase: acetonitrile-water (30–70); Flow rate: 1 mL·min −1 ; Column temperature: 37 °C; Uv detection wavelength: 210 nm. Based on common...
Characteristic cerebral pathological changes of Alzheimer's disease (AD) such as glucose hypometabolism or the accumulation cleavage products amyloid precursor protein (APP), known Aβ peptides, lead to sustained endoplasmic reticulum (ER) stress and neurodegeneration. To preserve ER homeostasis, cells activate their unfolded response (UPR). The rhomboid-like-protease 4 (RHBDL4) is an enzyme that participates in UPR by targeting proteins for proteasomal degradation. We demonstrated previously...
Blockade of epidermal growth factor receptor (EGFR) activity has been a primary therapeutic target for non-small cell lung cancers (NSCLC). As patients with wild-type EGFR have demonstrated only modest benefit from tyrosine kinase inhibitors (TKIs), there is need additional approaches in EGFR. key component downstream integrin signalling and known cross-talk EGFR, we hypothesized that targeting focal adhesion (FAK) activity, which also shown to correlate aggressive stage NSCLC, would lead...
The regulation of gene expression through histone posttranslational modifications plays a crucial role in breast cancer progression. However, the molecular mechanisms underlying contribution modification to tumor initiation remain unclear. To gain deeper understanding modifier Enhancer Zeste homology 2 (Ezh2) early stages mammary progression, we employed an inducible organoid system bearing conditional Ezh2 alleles that faithfully recapitulates key events luminal B initiation. We showed loss...
Abstract Obesity has been linked with the impairment of spatial memory and synaptic plasticity but molecular mechanisms remained unidentified. Since glutamatergic transmission NMDA receptor neural pathways in hippocampal dentate gyrus (DG) are essential learning memory, we aimed to investigate glutamate (Glu) signaling DG diet-induced obesity (DIO) rats. Spatial were assessed via Morris water maze (MWM) test on control (Ctr) DIO Extracellular concentration Glu was determined using vivo...
Beta-asarone (β-Asarone), the major component of Acorus tatarinowii Rhizoma, has been proved to be muti-pharmacological activities including anti-inflammation, and which is effective in protecting central nervous system. However, effect β-Asarone on myocardial ischemia–reperfusion (I/R) injury not yet clear. This study used a rat model with 45 min occlusion 24 h releasing proximal segment left anterior descending coronary artery. The effects cardiac histopathology, infarction size, levels...
Seven new amino acid derivatives (1–4 and 6–8) were isolated from MeOH extracts of the marine ascidian Herdmania momus. Planar structures established on basis NMR, IR, MS spectroscopic analyses. Absolute configurations these compounds derived specific rotation CD analysis. The peroxisome proliferator-activated receptor (PPAR)-γ agonistic activities investigated due to similarity structural motif that antidiabetic drug rosiglitazone. Analogues with indoleglyoxyl moieties (5, 6, 8) showed...
Although previous studies indicated that cumulus cells (CCs) accelerate oocyte aging by releasing soluble factors, the factors have yet to be characterized.While demonstrating CCs promoted Fas ligand (sFasL), our recent study suggested might secrete other mediate as well.This tested whether secreting tumor necrosis factor (TNF)-α.The results showed mouse undergoing apoptosis released TNF-α (sTNF-α) during in vitro aging.While ethanol activation rates were higher, maturation-promoting (MPF)...
Ovalbumin was used to induce allergic asthma following administration of YFP for one week in mice, collect the lung tissues, bronchoalveolar lavage fluid (BLFA), and feces. The pathological state, tight-junction proteins, inflammatory oxidative stress-associated biomarkers, TLRs/NF-κB signaling pathway tissues were evaluated by HE staining, immunofluorescence, ELISA, WB, separately. RT-PCR test genes. Leukocyte counts BLFA intestinal microbiota also analyzed using a hemocytometer 16S...
A new cyclic tetrapeptide (1), along with known congeners (2, 3), was isolated from the fungus Phoma sp. derived giant jellyfish Nemopilema nomurai. The absolute configuration of 1 determined using modified Mosher's method and Marfey's method. Compound displayed a weak suppressive effect on production nitric oxide (NO) in murine macrophage cells (RAW264.7) without notable cytotoxicity.
Mechanisms by which psychological stress damages oocytes are largely undetermined. Although a previous study showed that the stress-induced corticotrophin-releasing hormone (CRH) elevation impaired oocyte competence triggering apoptosis of ovarian cells, how CRH causes in cells and is unknown. In this study, we have examined hypothesis restraint (RS)-induced triggers impairs through activating Fas/FasL system. The results RS female mice competence, enhanced expression receptor (CRH-R) ovary,...
The physiological functions of the rhomboid-related protein 4 (RHBDL4) are emerging, but their molecular details remain unclear. Because increased expression RHBDL4 has been clinically linked to poorer outcomes in cancer patients, this association urgently demands a better understanding RHBDL4. To elucidate interactions and pathways that may be involved in, we conducted proximity-dependent biotin identification (BioID) assays. Our analyses corroborated several expected interactors such as...
Osteoporosis is a major public health problem that associated with high morbidity and mortality, its prevalence increasing as the world’s population ages. Therefore, understanding molecular basis of disease becoming priority. In this regard, studies have shown an imbalance in adipogenic osteogenic differentiation bone marrow mesenchymal stem cells (MSCs) osteoporosis. study, we conducted Weighted Gene Co-Expression Network Analysis to identify gene modules MSCs. Ontology Kyoto Encyclopedia...