A5100785282- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Phytochemical Studies and Bioactivities
- Inflammatory mediators and NSAID effects
- Toxin Mechanisms and Immunotoxins
- Plant biochemistry and biosynthesis
- Mangiferin and Mango Extracts
- Curcumin's Biomedical Applications
- Synthesis of Organic Compounds
- Tannin, Tannase and Anticancer Activities
- Peroxisome Proliferator-Activated Receptors
- Biological Stains and Phytochemicals
- Acupuncture Treatment Research Studies
- Bioactive natural compounds
- Chromatography in Natural Products
- Metabolomics and Mass Spectrometry Studies
- Plant-based Medicinal Research
- Natural Compounds in Disease Treatment
- Traditional Chinese Medicine Studies
- Folate and B Vitamins Research
Shenyang Pharmaceutical University
2015-2024
Targeting cellular function as a system rather than on the level of single target significantly increases therapeutic potency. In present study, we detect pathway salvianolic acid B (SalB) in vivo. Acute myocardial infarction (AMI) was induced rats followed by treatment with 10 mg/kg SalB. Hemodynamic detection and pathological stain, 2-dimensional electrophoresis, MALDI-TOF MS/MS, Western blot, identification, apoptosis assay transmission electron microscope were used to elucidate effects...
Eggplant, the fruit of Solanum melongena L. (Solanaceae), is applied externally to relieve symptoms chilblains in folk East Asia. However, mechanisms and biological ingredients are not clear. A network pharmacology approach was used shed light on eggplant against chilblains, which illustrated that anti-inflammation antioxidation mainly involved curative effects. Bioassay-guided assays led isolation 44 (1–44), including two new natural compounds (1–2) 42 known compounds. Thirteen (3–15) were...
This paper was designed to study metabolomic characters of the high-fat diet (HFD)-induced hyperlipidemia and intervention effects Mangiferin (MG).
Gypsum Fibrosum, as a classic heat-clearing medicine, is widely used in the clinical practice of traditional Chinese medicine(TCM). However, debates exist about material basis and mechanism its efficacy. Therefore, this paper reviewed recent research progress effect Fibrosum discussed for medicine. Ca~(2+) may inhibit upward movement temperature set point by regulating Na~+/Ca~(2+) level heat-regulating center. Moreover, trace elements rise body immune system, promoting absorption Ca~(2+),...
Conyza blinii Le'vl is a medicinal herb used for the treatment of inflammation in Chinese folk medicine. Its major bioactive constituents are triterpene saponins, most which contain 6-8 sugar residues. In this report, electrospray ionization tandem mass spectrometry fragmentation behaviors bisdesmosidic saponins (conyzasaponin A, B, and C) were studied both positive negative ion modes with an ion-trap spectrometer. full scan spectrometry, these gave predominant [M-H](-) [M+Na](+) ions,...
The herb pair of Salvia miltiorrhiza and Panax notoginseng has widely been used for improving coronary cerebral circulation in China. However, the exact contribution major active components S. P. to cardioprotection is far from clear. In present study, three representative ingredients, salvianolic acid B (SalB) ginsenoside Rg1 (Rg1) Rb1 (Rb1) notoginseng, were selected elucidate mechanism at ingredient level.The purity SalB, Rg1, was >99%, as detected by high-performance liquid...
In the present study, petroleum ether, dichloromethane, ethyl acetate, and n-butanol fractions of mango seed kernel exhibited different degrees antioxidant α-glucosidase inhibitory activity. Thus, quantitative qualitative analysis ether fraction was conducted by GC-MS. Among identified components, four unsaturated fatty acids had never been reported in natural products before, together with 19 known components. addition, 17 compounds were isolated elucidated from other active fractions....
Xing Zhangab, Min Ye*a, Rui Lia, Jun Yinb & De-An Guo*aa The State Key Laboratory of Natural and Biomimetic Drugs, School Pharmaceutical Sciences, Peking University, Beijing, People's Republic Chinab Traditional Chinese Materia Medica, Shenyang Shenyang, China
Abstract Two novel flavanone glycosides, homoeriodictyol 7‐ O‐β ‐ D ‐[6‐(3‐hydroxybutanoyl)glucopyranoside] (viscumneoside IX; 1 ) and O β ‐[6‐(3‐hydroxybutanoyl)glucopyranosyl](1→2)‐ ‐glucopyranoside X; 2 ), together with four known flavanoids, 2‐homoeriodictyol ( 3 viscumneoside I 4 III 5 4′,5‐dihydroxy‐3′‐methoxy‐7‐(2‐ α L ‐rhamnopyranosyl‐ ‐glucopyranosyloxy)flavanone 6 were isolated from stems leaves of Viscum coloratum. Their structures elucidated on the basis their NMR spectra,...
A series of N-substituted phthalimide derivatives were synthesized based on a pharmacophore study paecilocin (a natural PPAR-γ agonist) and synthetic leads. The introduction hydrophilic hydrophobic groups to the skeleton yielded compounds 3–14. Compound 7 showed significant activation in luciferase assay using rat liver Ac2F cells. Docking simulations that free hydroxyl group head suitable tail, including phenyl linker, beneficial for activation. rosiglitazone concentration-dependently...
Empirical studies have indicated that excessive tea consumption may potentially decrease folate levels within the human body. The main active component in green tea, epigallocatechin gallate (EGCG), significantly reduces concentration of 5-methyltetrahydrofolate (5-MTHF) both solution and serum. However, our findings also demonstrate pro-degradation effect EGCG on 5-MTHF can be reversed by L-ascorbic acid (AA). Subsequent investigations suggest could expedite degradation generating hydrogen...
This study discovered a natural flavonoid stabilizer for stabilizing 5-methyltetrahydrofolate (5-MTHF) since the instability of 5-MTHF affects accurate determination 5-MTHF. The optimal was selected from six compounds, comparing differences between stabilizers and traditional studying parameters solution. In addition, effect on evaluated under various environmental conditions. Differences in methods with without naringenin were compared. concentrations analyzed using validated liquid...
Two new β-dihydroagarofuran-type sesquiterpenes (1–2) were isolated and identified from the fruit of Celastrus orbiculatus Thunb, together with seventeen known compounds (3–19). The structures elucidated based on extensive spectroscopic analyses. cytotoxic activities 19 three cell lines, human acute promyelocytic leukemia HL-60, leukemic K562, colon cancer HCT-116 cells, evaluated in vitro. Compound 4 exhibited potent activity against HCT116 lines IC50 values 3.61 μΜ, 17.13 μΜ 10.15...