A5087815948- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Bone Metabolism and Diseases
- Natural product bioactivities and synthesis
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Genomics, phytochemicals, and oxidative stress
- Bioactive Natural Diterpenoids Research
- Traditional Chinese Medicine Analysis
- Spine and Intervertebral Disc Pathology
- RNA Interference and Gene Delivery
- Phytochemical compounds biological activities
- Bone health and treatments
- Cancer-related molecular mechanisms research
- Advanced Adaptive Filtering Techniques
- Ubiquitin and proteasome pathways
- Beetle Biology and Toxicology Studies
- Toxin Mechanisms and Immunotoxins
- Phytochemistry and Biological Activities
- Blind Source Separation Techniques
- Lipid metabolism and disorders
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
Binzhou University
2017-2025
Binzhou Medical University
2017-2025
Hebei University of Chinese Medicine
2025
Harbin Medical University
2024
Guangzhou Vocational College of Science and Technology
2024
Jinshan Hospital of Fudan University
2014-2024
Northeast Agricultural University
2024
Shihezi University
2008-2023
Nanjing Normal University
2016-2023
University of Chinese Academy of Sciences
2018-2023
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed formation is mostly unknown. Here, we show increased osteoclastic miR-214-3p associates with both elevated serum exosomal reduced elderly women fractures ovariectomized (OVX) mice. Osteoclast-specific knock-in mice rescued by osteoclast-targeted antagomir-214-3p treatment....
Paclitaxel (PTX) is among the most commonly used first-line drugs for cancer chemotherapy. However, its poor water solubility and indiscriminate distribution in normal tissues remain clinical challenges. Here we design synthesize a highly water-soluble nucleolin aptamer-paclitaxel conjugate (NucA-PTX) that selectively delivers PTX to tumor site. By connecting tumor-targeting aptamer (NucA) active hydroxyl group at 2' position of via cathepsin B sensitive dipeptide bond, NucA-PTX remains...
The main chemical component of cannabis, cannabidiol (CBD), has been shown to have antitumor properties. present study examined the in vitro effects CBD on human gastric cancer SGC-7901 cells. We found that significantly inhibited proliferation and colony formation Further investigation showed upregulated ataxia telangiectasia-mutated gene (ATM) p53 protein expression downregulated p21 cells, which subsequently levels CDK2 cyclin E, thereby resulting cell cycle arrest at G0–G1 phase. In...
The intermolecular radical addition to the carbonyl group is difficult due facile fragmentation of resulting alkoxyl radical. To date, ketones, a valuable approach construct quaternary carbon centers, remains formidable synthetic challenge. Here, we report first visible-light-induced alkyl boronic acid α-ketoacids enabled by Lewis activation. in situ boron complex formation confirmed various spectroscopic measurements and mechanistic probing experiments, which facilitates prevents cleavage...
Abstract The role of osteoclastic miRNAs in regulating osteolytic bone metastasis (OBM) breast cancer is still underexplored. Here, we examined the expression profiles osteoclastogenic human specimens and identified that miR-214-3p was significantly upregulated patients with OBM. Consistently, found increased within osteoclasts, which associated elevated resorption, during development OBM xenografted nude mice (BCX). Furthermore, genetic ablation prevent Conditioned medium from MDA-MB-231...
Hepatocellular carcinoma (HCC) is one of the cancer types with poor prognosis. To effectively treat HCC, new molecular targets and therapeutic approaches must be identified. 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine monophosphate (IMP) cyclohydrolase (ATIC), a bifunctional protein enzyme, catalyzes last two steps de novo purine biosynthetic pathway. Whether ATIC contributes to development remains unclear.ATIC mRNA levels in different human HCC samples or normal...
The first aryl carboxyl radical generation by the donor–acceptor complex with N-acyloxyphthalimides and Hantzsch esters is reported. Regio- chemoselective C(sp3)–H bond allylation enabled radicals visible light irradiation under mild metal-free conditions.
The cardiac ischemia-reperfusion (I/R) injury greatly influences the therapeutic effect and remains an urgent challenge in clinical therapy. Polypharmacology opens a new opportunity to design drugs with specific target for improving efficacy. In this study, we first forecasted that Rosmarinic acid (RosA) could be used treatment of cardiovascular disease using text mining, chemometric chemogenomic methods. Consistent positive drug (pioglitazone, PIO), subsequently validated RosA pretreatment...
Myricetin is a naturally occurring flavonoid with protective effects against variety of cancers. However, the molecular mechanism myricetin hepatocellular carcinoma (HCC) has still not been fully elucidated. Previous studies have indicated that YAP essential for cancer initiation and progression. whether contributes to anti-cancer remains unclear. Herein, we aimed investigate effect on HCC, identify underlying mechanisms. We report induced apoptosis proliferation inhibition in HepG2 Huh-7...
Emerging evidence has shown that cinobufagin, as an active ingredient of Venenum Bufonis, inhibits tumor development. The aim this study was to investigate the inhibitory effects cinobufagin on A375 human malignant melanoma cells. MTT and colony formation assays showed significantly inhibited cell proliferation formation. Additional studies demonstrated markedly increased levels ATM serine/threonine kinase (ATM) checkpoint 2 (Chk2) decreased division cycle 25C (CDC25C), cyclin-dependent 1...
Emerging evidence suggests that cinobufagin, an active ingredient in Venenum Bufonis, inhibits cell proliferation several tumor cells. However, the anti-tumor effect of cinobufagin on nasopharyngeal carcinoma and underlying molecular mechanisms are still unclear. In this study, we found significantly HK-1 Further analyses demonstrated induces cycle arrest at S phase cells through downregulating levels CDK2 cyclin E. Moreover, downregulates protein level Bcl-2 upregulates Bax, subsequently...
Abstract Terpenoids are a class of structurally complex, naturally occurring compounds found predominantly in plant, animal, and microorganism secondary metabolites. Classical terpenoids typically have carbon atoms multiples five follow well-defined skeletons, whereas noncanonical deviate from these patterns. These often result the methyltransferase-catalyzed methylation modification substrate units, leading to irregular skeletons. In this comprehensive review, various activities...