A5107409037- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- ATP Synthase and ATPases Research
- Hormonal Regulation and Hypertension
- Aortic aneurysm repair treatments
- Chromatography in Natural Products
- Cardiac Fibrosis and Remodeling
- Metabolomics and Mass Spectrometry Studies
- Aortic Disease and Treatment Approaches
- Pulmonary Hypertension Research and Treatments
- Natural product bioactivities and synthesis
- Infectious Aortic and Vascular Conditions
- Ion Transport and Channel Regulation
- Signaling Pathways in Disease
- Cardiovascular Function and Risk Factors
- Fungal Biology and Applications
- Pharmacological Effects of Natural Compounds
- Protease and Inhibitor Mechanisms
- Ubiquitin and proteasome pathways
- Plant biochemistry and biosynthesis
- Electron Spin Resonance Studies
- Phytochemistry and Biological Activities
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Drug Transport and Resistance Mechanisms
Chinese Academy of Sciences
2014-2024
Shanghai Institute of Materia Medica
2014-2024
Nanjing University of Chinese Medicine
2024
University of Chinese Academy of Sciences
2024
University of South China
2023-2024
Shandong Institute of Business and Technology
2018-2024
Huazhong University of Science and Technology
2024
Union Hospital
2024
Theranostics (New Zealand)
2024
Universiti Putra Malaysia
2023
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed formation is mostly unknown. Here, we show increased osteoclastic miR-214-3p associates with both elevated serum exosomal reduced elderly women fractures ovariectomized (OVX) mice. Osteoclast-specific knock-in mice rescued by osteoclast-targeted antagomir-214-3p treatment....
The development of renewable energy (RE) is an effective solution to address the global greenhouse effect and climate change. China's government has enacted a series RE policies that play important role in regulating developing strategy. national cannot be separated from multidimensional guidance support policies, policy analysis can one indicators industry trends. However, currently, few studies conducted research whether these are performing their intended functions roles driving...
Abstract In the present study, we found that celastrol, a natural compound with well‐known apoptosis‐inducing effect, could also induce paraptosis‐like cytoplasmic vacuolization in cancer cell lines including HeLa cells, A549 cells and PC‐3 derived from cervix, lung prostate, respectively. Further study using indicated vacuoles induced by celastrol might be dilation of endoplasmic reticulum. And, celastrol‐treated markers autophagy such as transformation microtubule‐associated protein 1...
Background: Circular RNAs (circRNAs) represent a subset of non-coding implicated in the regulation diverse biological processes, including tumorigenesis. However, expression and functional implications circ0060467 hepatocellular carcinoma (HCC) remain elusive. In this study, we aimed to elucidate role modulating progression HCC. Methods: Differentially expressed circRNAs HCC tissues were identified through circRNA microarray assays. Quantitative reverse transcription polymerase chain...
Licorice (Gancao) is derived from the dried roots and rhizomes of Glycyrrhiza species (Leguminosae) appears as a component herb in about 60% traditional Chinese medicine (TCM) prescriptions. Modern pharmacological studies have shown that flavonoids are one class major components responsible for bioactivities licorice. Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/QTOF MS) has proven to be powerful tool rapid profiling identification...
Chronic inflammation is closely related to the development, deterioration, and metastasis of tumors. Recently, many studies have shown that down-regulating expression by blocking nuclear factor-κB (NF-κB) signal transducer activator transcription 3 (STAT3) pathways could significantly inhibit tumor growth metastasis. The combined application curcumin (CUR) celecoxib (CXB) has been proven exert a synergistic antitumor effect via inhibiting activation NF-κB STAT3. TAT-NBD (TN) peptide, fusion...
Cardiac fibrosis is a deleterious consequence of hypertension which may further advance to heart failure and increased matrix metalloproteinase-9 (MMP-9) contributes the underlying mechanism. Therefore, new therapeutic strategies attenuate effects MMP-9 are urgently needed. In present study, we characterize salvianolic acid A (SalA) as novel inhibitor at molecular, cellular animal level. We expressed truncated form contains only catalytic domain (MMP-9 CD), used this active protein for...
Triterpenes are the main components with cytotoxicity in Ganoderma lucidum , which is used popularly as a complementary treatment for cancer therapy traditional Chinese medicine. To investigate possible interaction between chemotherapeutic agents and triterpenes extracted from G. of doxorubicin (DOX) combined (GTS) or lucidenic acid N (LCN), purified compound, was examined HeLa cells. The combinations targeting DOX GTS LCN resulted synergistic Moreover, to identify molecular targets GTS,...
Targeting cellular function as a system rather than on the level of single target significantly increases therapeutic potency. In present study, we detect pathway salvianolic acid B (SalB) in vivo. Acute myocardial infarction (AMI) was induced rats followed by treatment with 10 mg/kg SalB. Hemodynamic detection and pathological stain, 2-dimensional electrophoresis, MALDI-TOF MS/MS, Western blot, identification, apoptosis assay transmission electron microscope were used to elucidate effects...
HeLa cells treated with celastrol, a natural compound inhibitive effect on proteasome, exhibited increase in apoptotic rate and characteristics of apoptosis. To clarify the signal network activated by celastrol to induce apoptosis, both direct target proteins undirect were searched present study. Proteasome catalytic subunit β1 was predicted computational analysis be possible confirmed checking activity recombinant human proteasome vitro. Undirect target-related using proteomic studies...