A5071007723- Peptidase Inhibition and Analysis
- Chemokine receptors and signaling
- Platelet Disorders and Treatments
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Myasthenia Gravis and Thymoma
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Retinoids in leukemia and cellular processes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Medical Research and Treatments
- RNA Interference and Gene Delivery
- HER2/EGFR in Cancer Research
- interferon and immune responses
- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Natural product bioactivities and synthesis
- Gastrointestinal Tumor Research and Treatment
- Nanoparticle-Based Drug Delivery
- Viral-associated cancers and disorders
Pudong Medical Center
2017-2023
Fudan University
2017-2023
Taihe Hospital
2009-2011
Hubei University of Medicine
2011
Chronic inflammation is closely related to the development, deterioration, and metastasis of tumors. Recently, many studies have shown that down-regulating expression by blocking nuclear factor-κB (NF-κB) signal transducer activator transcription 3 (STAT3) pathways could significantly inhibit tumor growth metastasis. The combined application curcumin (CUR) celecoxib (CXB) has been proven exert a synergistic antitumor effect via inhibiting activation NF-κB STAT3. TAT-NBD (TN) peptide, fusion...
Abstract Trastuzumab, a humanized antibody targeting human epidermal growth factor receptor 2 (HER2), exhibits remarkable therapeutic efficacy against HER2‐positive gastric cancer. Acquired resistance to trastuzumab remains barrier patient survival and the mechanisms underlying this are still not well understood. The normal epithelial cell‐specific‐1 (NES1) gene, also named as KLK10, is recognized potential target for reversing resistance. aim of study was explore role KLK10 in (TR) cancer...
Hematologic malignancy is a serious disease that develops quickly and aggressively, severely threatening human health owing to its high mortality. The current study aimed evaluate the antitumor effects of isoferulic acid (IFA) on leukemia cells investigate possible molecular mechanisms. cancer cell lines (Raji, K562 Jurkat) were treated with IFA in dose‑dependent manner proliferation was measured by assay. Cell cycle arrest detected via flow cytometry using propidium iodide (PI) staining....
Clinically, arsenic trioxide (ATO) was applied to the treatment of acute promyelocytic leukemia (APL) as a reliable and effective frontline drug. However, administration regimen AsⅢ limited due its fast clearance, short therapeutic window toxicity well. Based on CD71 overexpressed APL cells, in present study, transferrin (Tf)-modified liposome (LP) established firstly encapsulate arsenic-nickel complex by nickel acetate gradient method. The AsⅢ-loaded liposomes (AsLP) exhibited feature...
目的 探讨Notch和PI3K/Akt两条信号通路对人食管腺癌细胞OE33增殖、侵袭及迁移能力的影响及两条信号通路之间的联系.方法 应用Notch信号通路阻滞剂DAPT和PI3K/Akt信号通路阻滞剂LY294002分别单独和联合处理OE33细胞,设置对照组;Western blot和实时定量PCR法检测OE33细胞中NICD、Hes1、p-Akt、PTEN蛋白和mRNA的表达变化;CCK-8法检测细胞的增殖抑制率;划痕实验用于检测细胞迁移能力的变化;Transwell细胞侵袭实验用于检测细胞的侵袭能力变化.结果...
Objective To investigate clinical significance of transforming growth factor-beta 1 ( TGF-β1 ) in patients with chronic idiopathic thrombocytopenic purpura(CITP). Methods The serum level 38 pa-tients initial CITP were detected using enzyme-linked immunosorbent assay(ELISA). Results was significantly higher than that the controls [( 132.57±5.17) μg/L vs 76.81±4.42) μ/L] P 0.05 ). There negative correlation between and platelet count(r = -0. 342 ,P < ,there positive megakaryo-cyte count (r...