A5102883662- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Nanoplatforms for cancer theranostics
- Diabetes Treatment and Management
- Boron Compounds in Chemistry
- Chemokine receptors and signaling
- Microfluidic and Bio-sensing Technologies
- Drug Transport and Resistance Mechanisms
- 3D Printing in Biomedical Research
- Gas Sensing Nanomaterials and Sensors
- Carbon and Quantum Dots Applications
- Advanced Sensor and Energy Harvesting Materials
- Graphene and Nanomaterials Applications
- Nanocluster Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Dermatology and Skin Diseases
- Ferroptosis and cancer prognosis
- Spinal Fractures and Fixation Techniques
- Thyroid Cancer Diagnosis and Treatment
- Surface Modification and Superhydrophobicity
- Metabolism, Diabetes, and Cancer
- Polysaccharides Composition and Applications
- Conducting polymers and applications
- Head and Neck Cancer Studies
- Phytochemicals and Antioxidant Activities
Central Hospital of Zibo
2020-2024
Nanjing University of Chinese Medicine
2024
Jiangsu Province Hospital
2024
Xuzhou Medical College
2020-2022
Fudan University
2017-2022
Northeast Forestry University
2021
Jiaxing University
2021
Tobacco Research Institute
2019
Chinese Academy of Agricultural Sciences
2019
Ministry of Agriculture and Rural Affairs
2019
Doxorubicin entrapped carbon dots (DOX-CDs) were prepared for bioimaging and enhanced intracellular drug delivery. The CDs synthesized via the hydrothermal method using citrate urea under 200 °C 1 h. Then, DOX was successfully conjugated on physicochemical interactions. DOX-CDs exhibited good crystal structure, remarkable aqueous stability, excellent photoluminescence property, a high quantum yield of 93%. fluorescent images revealed that could be readily taken up by cancer cells cell...
Chronic inflammation is closely related to the development, deterioration, and metastasis of tumors. Recently, many studies have shown that down-regulating expression by blocking nuclear factor-κB (NF-κB) signal transducer activator transcription 3 (STAT3) pathways could significantly inhibit tumor growth metastasis. The combined application curcumin (CUR) celecoxib (CXB) has been proven exert a synergistic antitumor effect via inhibiting activation NF-κB STAT3. TAT-NBD (TN) peptide, fusion...
It has been acknowledged that circulating tumor cells (CTCs) are promising biomarkers in liquid biopsy for cancer diagnosis and prognosis. However, the relationship between CTC number gastric scarcely quantitatively investigated. Moreover, single criterion of epithelial cell adhesion molecule (EpCAM) antibody/aptamer to specifically recognize CTCs cannot be universally applied clinical applications, as it fails EpCAM-negative CTCs. Herein, we propose simple, low-cost, dual-aptamer (EpCAM...
Mesenchymal stem cells (MSCs), exhibiting tumor-tropic and migratory potential, can serve as cellular carriers to improve the effectiveness of anticancer agents. However, several challenges, such safety issue, limited drug loading, conservation stemness migration MSCs, still remain in MSC-based delivery system. In present study, a novel nano-engineered MSC system was established by loading doxorubicin (DOX)–polymer conjugates for systemic treatment pulmonary metastasis breast cancer. For...
Circulating tumor cells (CTC) have been represented by different phenotypes due to the epithelial–mesenchymal transition (EMT), which are epithelial CTC (E-CTC), mesenchymal (M-CTC), and mixed (epithelial, mesenchymal) (EM-CTC). Limited work has systematically discussed associations of number, especially proportions E-CTC, M-CTC, EM-CTC in total CTC, with colorectal cancer (CRC) progressions via a simple method high performances. To achieve this goal, paper presents fabrication novel...
The rarity of circulating tumor cells (CTCs) poses a great challenge to their clinical application as reliable "liquid biopsy" markers for cancer diagnosis. Meanwhile, the epithelial–mesenchymal transition (EMT) led reduced efficiency in capturing with lost or downregulated epithelial cell adhesion molecule (EpCAM) expressions. In this study, we proposed an integrated, highly efficient strategy heterogeneous CTC capture and portable detection from blood non-small-cell lung (NSCLC) patients....
The primary objective of this study is to conduct a comprehensive screening and analysis differentially expressed genes related disulfidoptosis (DEDRGs) in thyroid carcinoma (THCA). This entails delving into the intricate characterization immune cell infiltration within THCA context subsequently formulating validating novel prognostic model.
Chitosan (CTS) constitutes a promising area in treatment of nose-related diseases as nasal drug delivery carrier. Astragalus polysaccharide (APS) significantly attenuates eosinophils and neutrophil-dominant airway inflammation, it has potential pharmaceutical application the severe asthma. The purpose this work was to prepare APS/CTS microspheres intended for by spray-drying method. characteristics were evaluated scanning electron microscope, Fourier transform infrared spectroscopy,...
A new coupled fiber optic humidity sensor based on a double-tapered twisted weakly structure coated with graphene oxide/polyvinyl alcohol (GO/PVA) film has been reported for the first time, to best of our knowledge. The adopts 2×2 coupler waist diameter 20 µm. GO/PVA composite is in area increase sensitivity sensor. thickness coating layer about 3 can realize linear sensing relative (RH) range 45%-85%RH dynamic response time 1.9 s and recovery 5.7 s. up 0.002/%RH, linearity as high 98.65%....
Novel peptidic glucagon receptor (GCGR) and glucagon-like peptide 1 (GLP-1R) dual agonists are reported to have increased efficacy over GLP-1R monoagonists for the treatment of diabetes obesity. We identified a novel Xenopus GLP-1-based GLP-1R/GCGR agonist (xGLP/GCG-13) designed with proper activity ratio favoring versus GCGR. However, clinical utility xGLP/GCG-13 is limited by its short in vivo half-life. Starting from xGLP/GCG-13, Cys mutation was performed, followed covalent side-chain...
This study aimed to evaluate the impact of adjuvant chemotherapy on survival rates, adverse events, and quality life (QOL) in patients with locally advanced nasopharyngeal carcinoma (NPC). A retrospective cohort was conducted, including firstly histologically confirmed non-metastatic stage III-IVB NPC between February 2018 2020, continuous follow-up data available, were chosen from medical records affiliated hospital Qingdao University Zibo Central Hospital. There 395 receiving concurrent...
Background Central sensitization is a main mechanism underlying pain. Incretin confined to mediate insulinmimetic effects, but recent study indicates that incretin may affect the central of pain. Objective This article reviews studies about effects on spinal cord in pain. Content This review summarized physiological characters and receptor localization incretin. Glucagon like peptide-1 (GLP-1) its receptor, glucose-dependent insulinotropic polypeptide (GIP) influence neuronal...
Objective To provide the normal value of atlas (C1) inner sagittal diameter in adults thus defining diagnostic developmental canal stenosis at C1 and to establish Jishuitan (JST) morphological classification for craniovertebral junction (CVJ) anomalies. Methods From December 2010 November 2018, 101 patients with various CVJ anomalies (50 males, 51 females; mean age 48.8±12.9 years, range 15-78 years; anomaly group) 857 (461 396 50.2±8.3 21-79 were enrolled a retrospective study. In...