A5090118307- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Free Radicals and Antioxidants
- Crystallization and Solubility Studies
- Advanced Drug Delivery Systems
- Wound Healing and Treatments
- X-ray Diffraction in Crystallography
- Advanced Nanomaterials in Catalysis
- Drug Solubulity and Delivery Systems
- Synthesis and biological activity
- Electrospun Nanofibers in Biomedical Applications
- Inhalation and Respiratory Drug Delivery
- Plasma Applications and Diagnostics
- Cancer, Lipids, and Metabolism
- Sirtuins and Resveratrol in Medicine
- Metal complexes synthesis and properties
- Genomics, phytochemicals, and oxidative stress
- Antimicrobial agents and applications
- Epigenetics and DNA Methylation
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer-related molecular mechanisms research
- Icing and De-icing Technologies
- Berberine and alkaloids research
- HER2/EGFR in Cancer Research
- Moringa oleifera research and applications
Weifang Medical University
2016-2023
China University of Petroleum, Beijing
2018
Lanzhou University
2011-2015
Shanghai Institute of Materia Medica
2015
Chinese Academy of Sciences
2015
Qufu Normal University
2006
Uppsala University
1996
Abstract Ferroptosis is an iron‐dependent, lipid peroxide‐driven cell death caused by inhibition of the cystine/glutamate transporter, which importance for survival triple‐negative breast cancer ( TNBC ) cells. Erastin a low molecular weight chemotherapy drug that induces ferroptosis; however, poor water solubility and renal toxicity have limited its application. Exosomes, as delivery vehicles with immunogenicity, high biocompatibility efficiency, attracted increasing attention in recent...
Selenium nanoparticles (SeNPs) have attracted increasing interest over the last decades because of their activities on redox balance in human body. However, SeNPs tend to aggregate into large clusters, resulting lower bioactivity, bioavailability and biocompatibility. Surface-capping agents play crucial roles its stabilization biological activity. Here, a green synthesis method for preparation Lycium barbarum polysaccharides capped using tea extracts as reductants under mild conditions, at...
Abstract Growing evidence confirms that ferroptosis plays an important role in tumor growth inhibition. However, some non‐small‐cell lung cancer (NSCLC) cell lines are less sensitive to erastin‐induced ferroptotic death. Elucidating the mechanism of resistance cells and increasing sensitivity erastin need be addressed. In our experiment, acetaminophen (APAP) cotreatment inhibited NSCLC viability promoted apoptosis, accompanied with attenuation glutathione ectopic increases lipid peroxides....
Cancer stem cell (CSC) cluster of triple-negative breast cancer (TNBC) is suggested to be responsible for therapy resistance, metastatic process and recurrence, yet the sensitivity CSC clusters TNBC ferroptosis remains elusive in a great measure. Current research revealed that epidermal growth factor receptor (EGFR) reinforced CD44-mediated clustering, whether blockade EGFR has synergistic effects on erastin-induced tumor inhibition still poorly understood. Here, we found fraction...
Abstract: High drug resistance, poor water solubility, short half-life, and low local concentration are obstacles for successful delivery of chemotherapeutic drugs lung cancer. A new method involving the use nanoparticles (NPs) pulmonary is proposed. However, NPs limited by particle size range considering that cannot be deposited directly into lungs. polymerized microspheres (polymeric microspheres, PMs) will result in suitable sizes retain advantages nanodrugs after redispersion when...
Nanoparticle-based drug delivery allows effective and sustained of therapeutic agents to solid tumors has completely changed how cancer is treated. As a new technology for medical applications, cold atmospheric plasma (CAP) shows great potential in selective treatment. The aim this work develop dual treatment approach by integrating CAP with novel paclitaxel (PTX)-loaded nanoparticles targeting A549 cells. For purpose, PTX-loaded core-shell magnetic were prepared through coaxial...
Suppression of tumor development by inducing ferroptosis may provide a potential remedy for triple-negative breast cancer, which is sensitive to intracellular oxidative imbalance. Recently, artemisinin (ART) and its derivatives have been investigated as anticancer agents the treatment highly aggressive cancers via induction iron-mediated cleavage endoperoxide bridge. Owing poor water solubility limited iron content, it challenging further application in antitumor therapy. Herein, we...
Abstract Resveratrol (3,5,4′‐trihydroxystilbene, RES), a star among dietary polyphenols, shows wide range of biological activities, but it is rapidly and extensively metabolized into its glucuronide sulfate conjugates as well to the corresponding reduced products. This begs question whether metabolites RES contribute in vivo activity. To explore this possibility, we synthesized glucuronidation (3‐GR 4′‐GR) reduction (DHR) metabolites, evaluated effect these structure modifications on...
Nasopharyngeal carcinoma (NPC) is a common epithelial malignancy that occurs in the nasopharynx and it one of high incidences malignant tumors China. As previous reports, berberine hydrochloride (BH) possesses repressive effect on proliferation various cancer types. But application BH was hampered for long time due to its hydrophobic properties, along with poor stability bioavailability. In this study, folate acid modified chitosan nanoparticles loaded (BH/FA-CTS NPs) were prepared by ionic...
Reactive oxygen species (ROS)-induced oxidative stress plays a key role in the pathogenesis and progression of psoriasis by causing inflammation. Antioxidative strategies eradicating ROS may serve as effective easy treatment options for psoriasis, while nanozymes with intrinsic antioxidant enzyme-like activity have not been explored treatment. The aim this study is to fabricate β-cyclodextrins (β-CDs)-modified ceria nanoparticles (β-CDs/CeO2 NPs) drug-loaded multimimic-enzyme activities...
The advent of enzyme-facilitated cascade events in which endogenous substrates within the human body are used to generate reactive oxygen species (ROS) has spawned novel cancer treatment possibilities. In this study, a supramolecular catalytic nanozyme system was successfully developed, exhibiting photothermal-enhanced multienzyme and glutathione (GSH) depletion activities ultimately triggering apoptosis-ferroptosis synergistic tumor therapy. fabricated using β-cyclodextrin-functionalized...
Natamycin (NAT) is the drug of choice for treatment fungal keratitis (FK). However, its inherent shortcomings, such as poor solubility, high dosing frequency, and long cycle, need to be urgently addressed by designing a new delivery widen clinical utility. Growing research has confirmed that clotrimazole (CLZ) plays significant role in growth inhibition. Hence, coaxial electrospray (CO-ES) technology used herein prepare nano-systems with an average hydrodynamic particle size 309-406 nm...