A5055569477- Nanoplatforms for cancer theranostics
- HER2/EGFR in Cancer Research
- Mycobacterium research and diagnosis
- Inflammasome and immune disorders
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Treatment and Pharmacology
- Photonic and Optical Devices
- Monoclonal and Polyclonal Antibodies Research
- Advanced MEMS and NEMS Technologies
- Tuberculosis Research and Epidemiology
- Advanced Nanomaterials in Catalysis
- Breast Cancer Treatment Studies
- Cell death mechanisms and regulation
- Advanced Breast Cancer Therapies
- Cancer, Hypoxia, and Metabolism
- Drug Solubulity and Delivery Systems
- Advanced biosensing and bioanalysis techniques
- Phagocytosis and Immune Regulation
- Microbial metabolism and enzyme function
- Advanced Glycation End Products research
- Diet and metabolism studies
- Biochemical Acid Research Studies
- Ferroptosis and cancer prognosis
- Advanced Drug Delivery Systems
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Xiamen University
2024
Soochow University
2024
Weifang Medical University
2021-2024
Collaborative Innovation Center of Chemistry for Energy Materials
2024
Soochow University
2024
Harbin Medical University
2020-2023
Third Affiliated Hospital of Harbin Medical University
2020-2023
Sichuan University
2023
Guangdong University of Technology
2023
Cancer stem cell (CSC) cluster of triple-negative breast cancer (TNBC) is suggested to be responsible for therapy resistance, metastatic process and recurrence, yet the sensitivity CSC clusters TNBC ferroptosis remains elusive in a great measure. Current research revealed that epidermal growth factor receptor (EGFR) reinforced CD44-mediated clustering, whether blockade EGFR has synergistic effects on erastin-induced tumor inhibition still poorly understood. Here, we found fraction...
COVID-19 struck the world suddenly and unexpectedly. Since traditional education requires face-to-face communication, to avoid further spreading of virus a majority part that has moved online. Our study attempts compare differences between online medical with unique course design education. We conducted retrospective analysis total 4,098 students 2019 2020, including two groups who received classroom for same subjects, respectively. Freshmen enrolled in September 2018 physiology pharmacology...
Bone defects are difficult to repair and reconstruct as bone regeneration remains technically challenging, with exogenous factors required accelerate this process. Biodegradable synthetic scaffolds promising materials for stimulating tissue repair. In study, we investigated whether a bilayer membrane that includes mineralized collagen (MC) chitosan (CS) delivering berberine (BER)-a typical Chinese herbal monomer-could promote healing in rat model. An MC/CS cast film was coated...
Tumor vaccine has been a research boom for cancer immunotherapy, while its therapeutic outcome is severely depressed by the vulnerable in vivo delivery efficiency. Moreover, tumor immune escape also another intractable issue, which badly whittled down Our study aims to solve above dilemmas cooperating minimalist nanovaccine with PD-1 blockade effective and feasible immunotherapy. The antigen adjuvant co-delivery was developed employing natural polycationic protamine (PRT) carry...
Chemoimmunotherapy has anchored a new blueprint for cancer management. As burgeoning approach, immunotherapy shifted the paradigm of traditional chemotherapy and opened up prospects treatment. Here, sequentially pH-responsive doxorubicin (DOX) delivery nanosystem is designed simultaneous tumor immunogenic cell death (ICD). DOX modified into pH-sensitive cis-aconityl-doxorubicin (CAD) being easily adsorbed by polycationic polyethylenimine (PEI), PEI/CAD complexes are in situ-shielded...
Growing evidence indicates that oxidative stress (OS) plays a pivotal role in Diabetic nephropathy (DN). In previous study we demonstrated ALA/LA protected HK-2 cells against high glucose-induced cytotoxicity. So aimed to establish the glucose injury model of and investigate beneficial effects on excessive production TGF-β1 possible mechanisms mediating effects.
The ancient Chinese wild rice (Zizania latifolia (Griseb) Turcz) (CWR) has valuable biological and medicinal functions. To assess the advantages lost in modern cultivated after domestication, we compared composition of bioactive compounds results proteomic analysis with those Indica (N22). We used routine methods to determine protein, total dietary fiber, amino acid, mineral substance, plant secondary metabolites, acid CWR N22. protein contents were two times that N22, levels calcium,...
Tumor-associated macrophages (TAMs) widely exist in the solid tumors, which participate entire course of tumor development and execute momentous impacts. Therefore, manipulating TAMs has been identified as an expecting strategy with immense potential for cancer therapy. Herein, a nanodrug delivery system was leveraged simultaneously targeting cells M2-type efficient colon The broad-spectrum anticancer chemotherapeutic drug doxorubicin (DOX) hitchhiked mannose-modified bovine serum albumin...
Abstract Background Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease. Its progression caused by various pathological mechanisms, including oxidative stress (OS), inflammation, and fibrosis. This study aimed to explore the effects alpha-linolenic acid (ALA)/ linoleic (LA) on preventing delaying interstitial fibrosis improving OS in DKD mice. Methods Male eight-week-old db/db mice were randomly allocated either model group, low-dose ALA/LA group (250 mg/kg·d),...