A5014371479- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Nanoplatforms for cancer theranostics
- Drug Solubulity and Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Wound Healing and Treatments
- Polysaccharides and Plant Cell Walls
- Silk-based biomaterials and applications
- Plasma Applications and Diagnostics
- Molecular Sensors and Ion Detection
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Vector-borne infectious diseases
- Ferroptosis and cancer prognosis
- Viral Infections and Vectors
- Carbon and Quantum Dots Applications
- Advancements in Transdermal Drug Delivery
- Phytochemistry and Biological Activities
- Cancer, Lipids, and Metabolism
- Dendrimers and Hyperbranched Polymers
- Corneal Surgery and Treatments
- Chromatography in Natural Products
- Lung Cancer Research Studies
- RNA Interference and Gene Delivery
Weifang Medical University
2014-2024
Weifang University
2018-2024
American Pharmacists Association
2018
Nanomed (Brazil)
2018
George Washington University
2017
Beijing University of Chinese Medicine
2016
Xinjiang University
2015
Changshu Institute of Technology
2015
Ocean University of China
2008-2011
Northeast Electric Power University
2007
Abstract Ferroptosis is an iron‐dependent, lipid peroxide‐driven cell death caused by inhibition of the cystine/glutamate transporter, which importance for survival triple‐negative breast cancer ( TNBC ) cells. Erastin a low molecular weight chemotherapy drug that induces ferroptosis; however, poor water solubility and renal toxicity have limited its application. Exosomes, as delivery vehicles with immunogenicity, high biocompatibility efficiency, attracted increasing attention in recent...
Selenium nanoparticles (SeNPs) have attracted increasing interest over the last decades because of their activities on redox balance in human body. However, SeNPs tend to aggregate into large clusters, resulting lower bioactivity, bioavailability and biocompatibility. Surface-capping agents play crucial roles its stabilization biological activity. Here, a green synthesis method for preparation Lycium barbarum polysaccharides capped using tea extracts as reductants under mild conditions, at...
Abstract Growing evidence confirms that ferroptosis plays an important role in tumor growth inhibition. However, some non‐small‐cell lung cancer (NSCLC) cell lines are less sensitive to erastin‐induced ferroptotic death. Elucidating the mechanism of resistance cells and increasing sensitivity erastin need be addressed. In our experiment, acetaminophen (APAP) cotreatment inhibited NSCLC viability promoted apoptosis, accompanied with attenuation glutathione ectopic increases lipid peroxides....
A red molecular probe for carbon monoxide (CO)-specific detection based on palladium-free mediated opening of spirolactam has been applied to establish a safe and powerful method detect image CO changes in biological systems.
Abstract: High drug resistance, poor water solubility, short half-life, and low local concentration are obstacles for successful delivery of chemotherapeutic drugs lung cancer. A new method involving the use nanoparticles (NPs) pulmonary is proposed. However, NPs limited by particle size range considering that cannot be deposited directly into lungs. polymerized microspheres (polymeric microspheres, PMs) will result in suitable sizes retain advantages nanodrugs after redispersion when...
Background: Nonscar wound healing is a desirable treatment for cutaneous wounds worldwide. Peptide OH-CATH30 (OH30) from king cobra can selectively regulate the innate immunity and create an anti-inflammatory micro-environment which might benefit nonscar healing. Purpose: To overcome enzymatic digestion control release of OH30, OH30 encapsulated in carboxymethyl chitosan nanoparticles (CMCS-OH30 NP) were prepared their effects on evaluated. Methods: CMCS-OH30 NP by mild ionic gelation method...
Nanoparticle-based drug delivery allows effective and sustained of therapeutic agents to solid tumors has completely changed how cancer is treated. As a new technology for medical applications, cold atmospheric plasma (CAP) shows great potential in selective treatment. The aim this work develop dual treatment approach by integrating CAP with novel paclitaxel (PTX)-loaded nanoparticles targeting A549 cells. For purpose, PTX-loaded core-shell magnetic were prepared through coaxial...
In this study, a new red lysosome-targeted fluorescence off–on probe has been rationally designed, synthesized and applied for the highly selective sensitive sensing of carboxylesterase in live cells, sera tissues. The was readily by coupling N-methylated benzoindole with 4-(acetyloxy)benzaldehyd, which acetyl group acted as quenching recognizing agent hemicyanine skeleton worked fluorescent signal unit. As consequence, prepared spectroscopic displays quite low background signal. Upon...
Suppression of tumor development by inducing ferroptosis may provide a potential remedy for triple-negative breast cancer, which is sensitive to intracellular oxidative imbalance. Recently, artemisinin (ART) and its derivatives have been investigated as anticancer agents the treatment highly aggressive cancers via induction iron-mediated cleavage endoperoxide bridge. Owing poor water solubility limited iron content, it challenging further application in antitumor therapy. Herein, we...
Nasopharyngeal carcinoma (NPC) is a common epithelial malignancy that occurs in the nasopharynx and it one of high incidences malignant tumors China. As previous reports, berberine hydrochloride (BH) possesses repressive effect on proliferation various cancer types. But application BH was hampered for long time due to its hydrophobic properties, along with poor stability bioavailability. In this study, folate acid modified chitosan nanoparticles loaded (BH/FA-CTS NPs) were prepared by ionic...
Melanoma is resistant to conventional chemotherapy and radiotherapy. Therefore, it essential develop a targeted, low-toxic, minimally invasive treatment. Here, DTIC/ICG-Fe3O4@TpBD BSP/HA microneedles (MNs) were designed fabricated, which can enhance targeting melanoma perform photothermal therapy (PTT) simultaneously synergistically exert anticancer effects. The system consisted of magnetic nanoparticles (DTIC/ICG-Fe3O4@TpBD), dissoluble matrix (Bletilla polysaccharide (BSP)/hyaluronic acid...
Owing to the uneven distribution of photothermal agents (PTAs), therapy (PTT) can damage normal tissues. The dynamic reversible covalent bond, which significantly improve oxidation stability drug and characteristics responsive release, thus improving conversion efficiency drug, is a feasible solution enhance selective PTT for tumor treatment. nanoassembly loaded curcumin (Cur) with boronate encapsulated Indocyanine Green (ICG) in phospholipid bilayer by self-assembly. pH-responsive...
Amphiphilic peptides modified by molecular design can self-assemble into specific nanostructures with interesting applications in the fields of biomedicine and biotechnology. Lysyl oxidase (LO) is ubiquitous human serum. However, enzymatic self-assembly amphiphilic remains a challenge for lipid-soluble drug delivery under induction LO. Here, we designed positively charged peptide, A6K2, that could stably to form nanovesicles. The lysine peptide molecule be covalently cross-linked enzyme...
A large proportion of benign prostatic hyperplasia (BPH) patients suffer from lower urinary tract symptoms after surgery due to the presence urothelium wounds. Rebamipide (RBM) exerts wound healing promotion and anti-inflammatory effects on various tissues, including urothelium. However, intravesical administration RBM is hindered its low solubility resulting unsustainable drug concentrations in bladder. In this study, RBM-loaded chitosan nanoparticles (RBM/CTS NPs) were prepared using ionic...
Peroxynitrite (ONOO-), a powerful biological oxidant, is produced in the mitochondria and reacts with many biomolecular targets under various pathological conditions, leading to range of disease states. In this work, we developed nanoliposome-encapsulated ratiometrically fluorescent probe (NRF) based on hemicyanine structure Cy-O obtained by facile synthesis. Upon reaction ONOO-, oxidation hydrolysis π-conjugation system within nanoliposome triggers response large-scale emission shift (238...
Natamycin (NAT) is the drug of choice for treatment fungal keratitis (FK). However, its inherent shortcomings, such as poor solubility, high dosing frequency, and long cycle, need to be urgently addressed by designing a new delivery widen clinical utility. Growing research has confirmed that clotrimazole (CLZ) plays significant role in growth inhibition. Hence, coaxial electrospray (CO-ES) technology used herein prepare nano-systems with an average hydrodynamic particle size 309-406 nm...