A5045803518- Antioxidant Activity and Oxidative Stress
- Retinoids in leukemia and cellular processes
- Cancer, Lipids, and Metabolism
- Biochemical Acid Research Studies
- Metabolism and Genetic Disorders
- Pelvic floor disorders treatments
- Retinal Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- Ureteral procedures and complications
- Bladder and Urothelial Cancer Treatments
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Eicosanoids and Hypertension Pharmacology
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Neonatal and fetal brain pathology
- Religion, Ecology, and Ethics
- Muscle metabolism and nutrition
- Advanced Glycation End Products research
- Theological Perspectives and Practices
- Retinopathy of Prematurity Studies
- RNA Research and Splicing
Weifang University
2025
Sichuan University of Science and Engineering
2024
Adamson University
2024
Texas Tech University Health Sciences Center
2013-2023
Texas Tech University
2013-2023
Cleveland Clinic Lerner College of Medicine
2023
Children’s Institute
2023
Tsinghua University
2004-2022
Shanghai University of Finance and Economics
2022
Shanxi Cardiovascular Hospital
2020
Increasing evidence suggests that dietary carotenoids may reduce the risk of breast cancer. However, anti-breast cancer effects have been controversial, albeit understudied. Here, we investigated specific on a wide range cell lines, and found among several (including β-carotene, lutein, astaxanthin), lutein significantly inhibits growth by inducing cell-cycle arrest caspase-independent death, but it has little effect primary mammary epithelial cells (PmECs). Moreover, lutein-mediated...
Regulation of the process neuronal death plays a central role both during development CNS and in adult brain. The transcription factor myocyte enhancer 2 (MEF2) critical survival. Cyclin-dependent kinase 5 (Cdk5) mediates neurotoxic effects by phosphorylating inhibiting MEF2. How Cdk5-dependent phosphorylation reduces MEF2 transactivation activity remained unknown. Here, we demonstrate novel mechanism which Cdk5, conjunction with caspase, inhibits Using primary cerebellar granule neuron as...
Nanoparticle-based drug delivery allows effective and sustained of therapeutic agents to solid tumors has completely changed how cancer is treated. As a new technology for medical applications, cold atmospheric plasma (CAP) shows great potential in selective treatment. The aim this work develop dual treatment approach by integrating CAP with novel paclitaxel (PTX)-loaded nanoparticles targeting A549 cells. For purpose, PTX-loaded core-shell magnetic were prepared through coaxial...
Retinal pigment epithelial (RPE) cells are central to retinal health and homoeostasis. Oxidative stress-induced damage the RPE occurs as part of pathogenesis age-related macular degeneration neovascular retinopathies (e.g., retinopathy prematurity, diabetic retinopathy). The xanthophyll carotenoids, lutein zeaxanthin, selectively taken up by RPE, preferentially accumulated in human macula, transferred photoreceptors. These xanthophylls protect macula (and broader retina) via their...
Despite numerous inquiries into protective roles of lycopene in prostate cancer prevention or therapy, little is known about mechanisms by which its metabolites inhibit cancer. The enzyme β-carotene 9',10'-oxygenase (BCO2), catalyzes asymmetric cleavage several carotenoids, the principal regulator metabolism, but range BCO2 biological functions incompletely understood. This study investigated expression and functional human Expression bco2 gene dramatically decreased tissue a cell lines as...
The smart construction of nano-photosensitizers (PSs) is significant for multipurpose applications, such as bioimaging, efficient photodynamic anti-tumor or anti-bacterial studies. This work reports a flexible self-assembling strategy the nano-PSs, in which PSs spontaneously form amorphous aggregates killing bacteria, self-assemble with tetraphenylethene (TPE) based glycoclusters (TPE-Glc4) to construct glyco-dots cell imaging and Tricyanofuran (TCF) TPE units were bridged furan thiophene...
ABSTRACT Rabies virus nucleoprotein (N) plays vital roles in regulation of viral RNA transcription and replication by encapsidation the nascent genomic RNA. N is phosphorylated, previous studies demonstrated that mutation phosphorylated serine at position 389 to alanine resulted reduction and/or a rabies minigenome. In present study, we mutated (S) (A), glycine (G), aspartic acid (D), asparagine (N), glutamic (E), glutamine (Q) examined effects these mutations on Furthermore, from S A, D, E...
Aim To prepare and characterise lutein-loaded polylactide-co-glycolide–polyethylene glycol–folate (PLGA-PEG-FOLATE) nanoparticles evaluate enhanced uptake in SK-N-BE(2) cells.Methods Nanoparticles were prepared using O/W emulsion solvent evaporation characterised DLS, SEM, DSC, FTIR in-vitro release. Lutein-uptake cells was determined flow-cytometry, confocal-microscopy HPLC. Control lutein PLGA nanoparticles.Results The size of PLGA-PEG-FOLATE 189.6 ± 18.79 nm 188.0 4.06 nm, respectively....
Abstract Background Vitamin A and its derivatives, the retinoids, are essential for normal embryonic development maintenance of cell differentiation. β, β-carotene 15,15'-monooxygenase 1 (BCMO1) catalyzes central cleavage to all- trans retinal is key enzyme in intestinal metabolism carotenes vitamin A. However, human various rodent species show markedly different efficiencies BCMO1-mediated carotene retinoid conversion. The aim this study identify potentially human-specific regulatory...
Development of the human placenta and its trophoblast cell types is critical for a successful pregnancy. Defects in invasion differentiation are associated with adverse pregnancy outcomes, including preeclampsia. The members myocyte enhancer factor-2 (MEF2) family transcription factors key regulators cellular proliferation, differentiation, various tissues might play similarly important role regulating invasion, during placental development. In present study, using cytotrophoblast lines...
The dihydrolipoyl acetyltransferase (E2 component) is a 60-mer assembled via its COOH-terminal domain with exterior E1-binding and two lipoyl domains (L2 then L1) sequentially connected by mobile linker regions. E2 facilitates markedly enhanced function of the pyruvate dehydrogenase kinase (PDK) phosphatase (PDP). Human structures were prepared only one (L1 or L2) alanines substituted at sites lipoylation (Lys-46 in L1 Lys-173 L2). L2 group shown to be essential for PDP required greatly...
The inner lipoyl domain (L2) of the dihydrolipoyl acetyltransferase (E2) 60-mer forms a Ca2+-dependent complex with pyruvate dehydrogenase phosphatase 1 (PDP1) or its catalytic subunit, PDP1c, in facilitating large enhancements activities PDP1 (10-fold) PDP1c (6-fold). L2 binding to requires lipoyl-lysine prosthetic group and specificity residues that distinguish from other domains (L1 E2 L3 E3-binding component). L2-surface structure contributing was mapped by comparing capacities well...
Endometriosis is a common gynecological disease among women in their reproductive years. Although much effort has been made, the pathogenesis of this and detailed differences between eutopic endometrial cells ectopic are still unclear.In study, were collected from patients with without endometriosis RNA sequencing was performed. The gene expression patterns differentially expressed genes (DEGs) cells, as well control analyzed using weighted co-expression network analysis (WGCNA) DESeq2...
β-carotene 15,15'-oxygenase (BCO1) catalyzes the first step in conversion of dietary provitamin A carotenoids to vitamin A. This enzyme is expressed a variety developing and adult tissues, suggesting that its activity may regulate local retinoid synthesis. Vitamin related compounds (retinoids) are critical regulators lung epithelial development, integrity, injury repair. balance between actions retinoids glucocorticoids (GCs) promotes normal development and, particular, alveolarization....