A5090030002- Folate and B Vitamins Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Diet and metabolism studies
- Nutritional Studies and Diet
- Sirtuins and Resveratrol in Medicine
- Birth, Development, and Health
- Esophageal and GI Pathology
- Metabolism and Genetic Disorders
- Trace Elements in Health
- Nutrition, Genetics, and Disease
- Cancer-related Molecular Pathways
- Liver Disease Diagnosis and Treatment
- Nuts composition and effects
- Cancer Risks and Factors
- Nutrition, Health and Food Behavior
- Nutrition and Health in Aging
- Acute Myeloid Leukemia Research
- Drug Transport and Resistance Mechanisms
- Antioxidant Activity and Oxidative Stress
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Digestive system and related health
- Genetic factors in colorectal cancer
CHA University
2016-2025
University of Massachusetts Amherst
2014-2024
CHA Gangnam Medical Center
2019-2021
CHA Bundang Medical Center
2018-2020
Tufts University
2010-2019
Jean Mayer Human Nutrition Research Center on Aging
2007-2019
Kyungpook National University
2017
Food & Nutrition
2017
United States Department of Agriculture
2000-2014
University of Verona
2002-2014
DNA methylation, an essential epigenetic feature of that modulates gene expression and genomic integrity, is catalyzed by methyltransferases use the universal methyl donor S -adenosyl- l -methionine. Methylenetetrahydrofolate reductase (MTHFR) catalyzes synthesis 5-methyltetrahydrofolate (5-methylTHF), for methionine from homocysteine precursor In present study we sought to determine effect folate status on methylation with emphasis interaction common C677T mutation in MTHFR gene. A liquid...
Abstract 5-Aza-2′-deoxycytidine (decitabine) is postulated to have clinical activity in myeloid leukemias via its ability inhibit DNA methylation. To study this, we examined methylation patients with leukemia treated decitabine. Five days after the treatment, total genomic 5-methylcytosine/cytosine decreased on average by 14% (from 4.3% 3.7%), whereas of repetitive elements showed a mean decrease 9% and 16% for Alu long interspersed nucleotide elements, respectively. Methylation linearly...
Eukaryotic DNA is methylated at some cytosine residues, and this epigenetic feature performs critical functions. We developed a method for quantitative determination of 5-methyl-2'-deoxycytidine in human using liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS). The was enzymatically hydrolyzed by sequential digestion with three enzymes. hydrolyzates were subsequently separated reversed-phase high-performance chromatography isocratic mode. four major bases resolved...
BACKGROUND AND AIMS: Diminished folate status is associated with enhanced colorectal carcinogenesis. This study investigated the potential chemopreventive role of dietary in dimethylhydrazine cancer model. SUBJECTS METHODS: Sprague-Dawley rats were fed diets containing either 0, 2 (daily requirement), 8 or 40 mg folate/kg diet for 20 weeks. After five weeks diet, injected dimethyl-hydrazine (44 mg/kg) weekly 15 Fifteen after first injection dimethylhydrazine, all killed. Folate was...
Alcohol is a well-known risk factor for hepatocellular carcinoma (HCC), but the mechanisms underlying alcohol-related hepatocarcinogenesis are still poorly understood. alters provision of methyl groups within hepatic one-carbon metabolism, possibly inducing aberrant DNA methylation. Whether specific pathways epigenetically regulated in alcohol-associated HCC is, however, unknown. The aim present study was to investigate genome-wide promoter methylation and gene expression profiles non-viral,...
Abstract No biomarker can effectively screen for early gastric cancer (EGC). Players in the A disintegrin and metalloproteinase (ADAM)-natural killer group 2 member D (NKG2D) receptor axis may have a role that. As proof-of-concept pilot study, expression of ADAM8, ADAM9, ADAM10, ADAM12, ADAM17, major histocompatibility complex (MHC) class I chain-related sequence (MICA), ligand NKG2D, was investigated silico using The Cancer Genome Atlas (TCGA) database. Subsequently, mRNA protein levels...