A5088716375- Folate and B Vitamins Research
- Esophageal and GI Pathology
- Metabolism and Genetic Disorders
- Iron Metabolism and Disorders
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Fluoride Effects and Removal
- Pregnancy and Medication Impact
- HIV-related health complications and treatments
- Pregnancy and preeclampsia studies
- Trace Elements in Health
- Child Nutrition and Feeding Issues
- RNA modifications and cancer
- Diet and metabolism studies
- Cancer Risks and Factors
- Biochemical and Molecular Research
- Neurological Complications and Syndromes
- GDF15 and Related Biomarkers
- Gastroesophageal reflux and treatments
- Alcoholism and Thiamine Deficiency
- Birth, Development, and Health
- Pharmacological Effects and Toxicity Studies
- Liver Disease Diagnosis and Treatment
- Vitamin C and Antioxidants Research
Jean Mayer Human Nutrition Research Center on Aging
2013-2024
Tufts University
2013-2024
Harvard University
1998-2015
Brigham and Women's Hospital
2002-2015
Boston University
1995-2015
Dana-Farber Cancer Institute
2005-2015
Brown University
2001-2015
University of California, Davis
2000-2012
National Cancer Institute
1999-2012
Division of Cancer Epidemiology and Genetics
2009-2012
In cross-sectional studies, elevated plasma homocysteine levels have been associated with poor cognition and dementia. Studies of newly diagnosed dementia are required in order to establish whether the precede onset or result from dementia-related nutritional vitamin deficiencies.
Background Methylenetetrahydrofolate reductase (MTHFR) synthesizes 5-methyltetrahydrofolate, the major carbon donor in remethylation of homocysteine to methionine. A common MTHFR mutation, an alanine-to-valine substitution, renders enzyme thermolabile and may cause elevated plasma levels amino acid homocysteine. Methods Results To assess potential interaction between this mutation vitamin coenzymes metabolism, we screened 365 individuals from NHLBI Family Heart Study. Among with lower folate...
Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting risk cardiovascular events.We measured 10 in 3209 participants attending a routine examination cycle Framingham Heart Study: levels C-reactive protein, B-type natriuretic peptide, N-terminal pro-atrial aldosterone, renin, fibrinogen, D-dimer, plasminogen-activator inhibitor type 1, and homocysteine; urinary albumin-to-creatinine ratio.During follow-up (median,...
Epidemiologic studies have identified hyperhomocysteinemia as a possible risk factor for atherosclerosis. We determined the of carotid-artery atherosclerosis in relation to both plasma homocysteine concentrations and nutritional determinants hyperhomocysteinemia.
DNA methylation, an essential epigenetic feature of that modulates gene expression and genomic integrity, is catalyzed by methyltransferases use the universal methyl donor S -adenosyl- l -methionine. Methylenetetrahydrofolate reductase (MTHFR) catalyzes synthesis 5-methyltetrahydrofolate (5-methylTHF), for methionine from homocysteine precursor In present study we sought to determine effect folate status on methylation with emphasis interaction common C677T mutation in MTHFR gene. A liquid...
The increased prevalence of osteoporosis among people with homocystinuria suggests that a high serum homocysteine concentration may weaken bone by interfering collagen cross-linking, thereby increasing the risk osteoporotic fracture. We examined association between total and hip fracture in men women enrolled Framingham Study.We studied 825 1174 women, ranging age from 59 to 91 years, whom blood samples had been obtained 1979 1982 measure plasma homocysteine. participants our study were...
Hyperhomocysteinemia appears to be an independent risk factor for coronary disease. Elevated levels of plasma total homocysteine (tHCY) can result from genetic or nutrient-related disturbances in the transsulfuration remethylation pathways metabolism. The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes reduction 5-methyltetrahydrofolate, predominant circulatory form folate, which serves as a methyl donor methionine. A common mutation MTHFR recently has been identified.We...
Abstract Nationwide fortification of enriched uncooked cereal grains with folic acid began in the United States and Canada 1996 1997, respectively, became mandatory 1998. The rationale was to reduce number births complicated by neural tube defects. Concurrently, experienced abrupt reversals downward trend colorectal cancer (CRC) incidence that two countries had enjoyed preceding decade: absolute rates CRC increase (United States) 1998 (Canada), peaked 2000 have continued exceed pre-1996/1997...
Background: Total homocysteine levels are associated with arteriosclerotic outcomes. Objective: To determine whether total predict incident stroke in elderly persons. Design: Prospective population-based cohort study 9.9 years of follow-up. Setting: Framingham, Massachusetts. Patients: 1947 Framingham Study participants (1158 women and 789 men; mean age ± SD, 70 7 years). Measurements: Baseline 9.9-year incidence. Results: The quartiles nonfasting were as follows: quartile 1, 4.13 to 9.25...
Background High plasma homocysteine is associated with premature coronary artery disease in men, but the threshold concentration defining this risk and its importance women elderly are unknown. Furthermore, although low B vitamin status increases homocysteine, link between these vitamins unclear. Methods Results We compared 304 patients 231 control subjects. Risk factors concentrations of folate, B12, pyridoxal 5′-phosphate were documented. A 14 μmol/L conferred an odds ratio 4.8 ( P...
<h3>Objective.</h3> —To describe the distribution of plasma homocysteine concentrations in an elderly population and to analyze relationship between level intake vitamins serum levels that serve as coenzymes metabolism. <h3>Design.</h3> —Cross-sectional analysis vitamin blood participants Framingham Study. <h3>Setting.</h3> —Population-based cohort Framingham, Mass. <h3>Participants.</h3> —A total 1160 adult survivors, aged 67 96 years, from original Heart Study cohort. <h3>Main Outcome...
Background— The relationship of circulating levels high-sensitivity C-reactive protein (CRP) with cardiovascular disease (CVD) risk, particularly consideration effects at intermediate has not been fully assessed. Methods and Results— Among 3006 offspring participants in the Framingham Heart Study free CVD (mean age, 46 years baseline), there were 129 hard coronary heart (CHD) events 286 total during 12 follow-up. Cox regression, discrimination area under receiver operating characteristic...
Biomarkers of multiple pathophysiological pathways have been related to incident atrial fibrillation (AF), but their predictive ability remains controversial.In 3120 Framingham cohort participants (mean age 58.4+/-9.7 years, 54% women), we 10 biomarkers that represented inflammation (C-reactive protein and fibrinogen), neurohormonal activation (B-type natriuretic peptide [BNP] N-terminal proatrial peptide), oxidative stress (homocysteine), the renin-angiotensin-aldosterone system (renin...
A common mutation (C677T) in the gene encoding for methylenetetrahydrofolate reductase (MTHFR) (5-methyltetrahydrofolate:(acceptor) oxidoreductase, EC 1.7.99.5 ), a key regulatory enzyme one-carbon metabolism, results thermolabile variant of MTHFR with reduced activity vitro . In present study we used chromatographic method folate analysis to test hypothesis that this would be associated altered distribution red blood cell (RBC) folates. An alteration was found as manifested by presence...
Background: The concentration of circulating total homocysteine is a sensitive marker inadequate folate and vitamin B12 status. Elevated concentrations are associated with an increased risk for vascular disease. Objective: To identify reference ranges serum in U.S. residents quantify the contribution to high concentrations. Design: Cross-sectional prevalence study. Setting: United States. Patients: A nationally representative sample 3563 male participants 4523 female 12 years age or older...