A5064623534- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Heart Failure Treatment and Management
- Genetic Associations and Epidemiology
- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Atrial Fibrillation Management and Outcomes
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Health and Risk Factors
- Cardiovascular and exercise physiology
- Cardiac electrophysiology and arrhythmias
- Hormonal Regulation and Hypertension
- Nutritional Studies and Diet
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- MicroRNA in disease regulation
- Diet and metabolism studies
- Cardiovascular Effects of Exercise
- Chronic Kidney Disease and Diabetes
- Cardiac Valve Diseases and Treatments
- Birth, Development, and Health
- GDF15 and Related Biomarkers
National Heart Lung and Blood Institute
2016-2025
Boston University
2015-2024
Framingham Heart Study
2015-2024
Indiana University School of Medicine
2024
Indiana University – Purdue University Indianapolis
2024
University of Massachusetts Chan Medical School
1992-2023
Duke-NUS Medical School
2023
British Heart Foundation
2023
University of Glasgow
2023
Lung Institute
2013-2022
Extreme obesity is recognized to be a risk factor for heart failure. It unclear whether overweight and lesser degrees of also pose risk.We investigated the relation between body-mass index (the weight in kilograms divided by square height meters) incidence failure among 5881 participants Framingham Heart Study (mean age, 55 years; 54 percent women). With use Cox proportional-hazards models, was evaluated both as continuous variable categorical (normal, 18.5 24.9; overweight, 25.0 29.9;...
We attempted to characterize age-related changes in blood pressure both normotensive and untreated hypertensive subjects a population-based cohort from the original Framingham Heart Study infer underlying hemodynamic mechanisms.A total of 2036 participants were divided into four groups according their systolic (SBP) at biennial examination 10, 11, or 12. After excluding receiving antihypertensive drug therapy, up 30 years data on examinations 2 through 16 used. Regressions versus age within...
Heart failure is a major public health problem. Long-term trends in the incidence of heart and survival after its onset community have not been characterized.
Information is limited regarding the risk of cardiovascular disease in persons with high-normal blood pressure (systolic 130 to 139 mm Hg, diastolic 85 89 or both).
Various measures of arterial stiffness and wave reflection have been proposed as cardiovascular risk markers. Prior studies not assessed relations a comprehensive panel to prognosis in the community.We used proportional hazards models analyze first-onset major disease events (myocardial infarction, unstable angina, heart failure, or stroke) relation (pulse velocity [PWV]), (augmentation index, carotid-brachial pressure amplification), central pulse 2232 participants (mean age, 63 years; 58%...
Background— Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity mortality, but lifetime risk for AF has not been estimated. Methods Results— We included all participants in Framingham Heart Study who were free at index ages 40 years older. estimated risks (including atrial flutter) to age 95 years, with death as competing event. followed 3999 men 4726 women from 1968 1999 (176 166 person-years); 936 had development 2621 died without prior...
Background— Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur together, but there is limited information regarding their temporal relations the combined influence of these conditions on mortality. Methods Results— We studied participants in Framingham Study with new-onset AF or CHF. Multivariable Cox proportional hazards models time-dependent variables were used to evaluate whether mortality after CHF was affected by occurrence timing other condition. Hazard ratios...
Background —Current definitions of hypertension are based on levels systolic blood pressure (SBP) and diastolic (DBP), but not pulse (PP). We examined whether PP adds useful information for predicting coronary heart disease (CHD) in the population-based Framingham Heart Study. Methods Results —We studied 1924 men women between 50 79 years age at baseline with no clinical evidence CHD taking antihypertensive drug therapy. Cox regression, adjusted age, sex, other risk factors, was used to...
Although heart rate variability (HRV) is altered in a variety of pathological conditions, the association reduced HRV with risk for new cardiac events has not been studied large community-based population.The first 2 hours ambulatory ECG recordings obtained on subjects Framingham Heart Study who were free clinically apparent coronary disease or congestive failure reprocessed to assess HRV. Five frequency-domain measures and three time-domain obtained. The associations between incidence...
Background— Congestive heart failure (CHF) is an increasing public health problem. Methods and Results— Among Framingham Heart Study subjects who were free of CHF at baseline, we determined the lifetime risk for developing overt selected index ages. We followed 3757 men 4472 women from 1971 to 1996 124 262 person-years; 583 developed 2002 died without prior CHF. At age 40 years, was 21.0% (95% CI 18.7% 23.2%) 20.3% 18.2% 22.5%) women. Remaining did not change with advancing because rapidly...
The natriuretic peptides are counterregulatory hormones involved in volume homeostasis and cardiovascular remodeling. prognostic significance of plasma peptide levels apparently asymptomatic persons has not been established.
With advancing age, arterial stiffness and wave reflections increase elevate systolic pulse pressures. An elevated central pressure is generally ascribed to increased reflection portends an unfavorable prognosis. Using tonometry, we evaluated (carotid-femoral) peripheral (carotid-brachial) velocity, amplitudes of forward reflected waves, augmentation index in 188 men 333 women the Framingham Heart Study offspring cohort who were free clinical cardiovascular disease, hypertension, diabetes,...
ContextThe long-term risk for developing hypertension is best described by the lifetime statistic. The and trends in this over time are unknown.ObjectivesTo estimate residual older US adults to evaluate temporal risk.Design, Setting, ParticipantsCommunity-based prospective cohort study of 1298 participants from Framingham Heart Study who were aged 55 65 years free at baseline (1976-1998).Main Outcome MeasuresResidual (lifetime cumulative incidence not adjusted competing causes mortality)...
Background —We examined the relative importance of diastolic (DBP), systolic (SBP) and pulse pressure (PP) as predictors coronary heart disease (CHD) risk in different age groups Framingham Heart Study participants. Methods Results studied 3060 men 3479 women between 20 79 years who were free CHD not on antihypertensive drug therapy at baseline. Cox regression adjusted for age, sex, other factors was used to assess relations BP indexes over a 20-year follow-up. In group <50 DBP strongest...
Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting risk cardiovascular events.We measured 10 in 3209 participants attending a routine examination cycle Framingham Heart Study: levels C-reactive protein, B-type natriuretic peptide, N-terminal pro-atrial aldosterone, renin, fibrinogen, D-dimer, plasminogen-activator inhibitor type 1, and homocysteine; urinary albumin-to-creatinine ratio.During follow-up (median,...
Objective— To determine the clinical conditions associated with systemic oxidative stress in a community-based cohort. Information regarding cardiovascular risk factors has largely been derived from highly selected samples advanced stages of vascular disease. Thus, it difficult to evaluate relative contribution each factor and whether such act independently are applicable general population. Methods Results— We examined 2828 subjects Framingham Heart Study measured urinary creatinine–indexed...
Background: Hyperuricemia is associated with risk for cardiovascular disease and death. However, the role of uric acid independent established factors uncertain. Objective: To examine relation serum level to incident coronary heart disease, death from all causes. Design: Community-based, prospective observational study. Setting: Framingham, Massachusetts. Patients: 6763 Framingham Heart Study participants (mean age, 47 years). Measurements: Serum at baseline (1971 1976); event rates per 1000...
Lifetime risk for atherosclerotic cardiovascular disease (CVD) has not previously been estimated, and the effect of factor burden on lifetime is unknown.We included all Framingham Heart Study participants who were free CVD (myocardial infarction, coronary insufficiency, angina, stroke, claudication) at 50 years age. risks to 95 age estimated men women, with death as a competing event. We followed up 3564 4362 women 111,777 person-years; 1757 had events 1641 died CVD. At age, 51.7% (95% CI,...
Little is known about the epidemiology and prognosis of syncope in general population.We evaluated incidence, specific causes, among women men participating Framingham Heart Study from 1971 to 1998.Of 7814 study participants followed for an average 17 years, 822 reported syncope. The incidence a first report was 6.2 per 1000 person-years. most frequently identified causes were vasovagal (21.2 percent), cardiac (9.5 orthostatic (9.4 percent); 36.6 percent cause unknown. multivariable-adjusted...
Little information is available on the prevalence and determinants of valvular regurgitation in general population. This study sought to assess clinical mitral (MR), tricuspid (TR), aortic (AR) a population-based cohort. Color Doppler echocardiography was performed 1,696 men 1,893 women (aged 54 ± 10 years) attending routine examination at Framingham Study. After excluding technically poor echocardiograms, MR, TR, AR were qualitatively graded from trace severe. Multiple logistic regression...