A5064192696- Nutritional Studies and Diet
- Folate and B Vitamins Research
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Nutrition and Health in Aging
- Esophageal and GI Pathology
- Iron Metabolism and Disorders
- Consumer Attitudes and Food Labeling
- Antioxidant Activity and Oxidative Stress
- Vitamin C and Antioxidants Research
- Diet, Metabolism, and Disease
- Nutrition, Genetics, and Disease
- Metabolism and Genetic Disorders
- Food composition and properties
- Vitamin K Research Studies
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Connexins and lens biology
- Birth, Development, and Health
- Fluoride Effects and Removal
- Pregnancy and Medication Impact
- Epigenetics and DNA Methylation
- Fatty Acid Research and Health
- Nutrition, Health and Food Behavior
- Adipokines, Inflammation, and Metabolic Diseases
Jean Mayer Human Nutrition Research Center on Aging
2015-2024
Tufts University
2015-2024
Framingham Heart Study
2002-2024
United States Department of Agriculture
2003-2020
University of East Anglia
2020
University of New England
2020
George Mason University
2020
David H. Murdock Research Institute
2020
North Carolina State University
2020
Boston University
2002-2017
In cross-sectional studies, elevated plasma homocysteine levels have been associated with poor cognition and dementia. Studies of newly diagnosed dementia are required in order to establish whether the precede onset or result from dementia-related nutritional vitamin deficiencies.
Background— Vitamin D receptors have a broad tissue distribution that includes vascular smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests vitamin deficiency may adversely affect the cardiovascular system, but data from longitudinal studies are lacking. Methods Results— We studied 1739 Framingham Offspring Study participants (mean age 59 years; 55% women; all white) without prior disease. status was assessed by measuring 25-dihydroxyvitamin (25-OH D) levels....
Overweight in adults is associated with increased morbidity and mortality. In contrast, the long-term effect of overweight adolescence on mortality not known.
Background Methylenetetrahydrofolate reductase (MTHFR) synthesizes 5-methyltetrahydrofolate, the major carbon donor in remethylation of homocysteine to methionine. A common MTHFR mutation, an alanine-to-valine substitution, renders enzyme thermolabile and may cause elevated plasma levels amino acid homocysteine. Methods Results To assess potential interaction between this mutation vitamin coenzymes metabolism, we screened 365 individuals from NHLBI Family Heart Study. Among with lower folate...
Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting risk cardiovascular events.We measured 10 in 3209 participants attending a routine examination cycle Framingham Heart Study: levels C-reactive protein, B-type natriuretic peptide, N-terminal pro-atrial aldosterone, renin, fibrinogen, D-dimer, plasminogen-activator inhibitor type 1, and homocysteine; urinary albumin-to-creatinine ratio.During follow-up (median,...
Epidemiologic studies have identified hyperhomocysteinemia as a possible risk factor for atherosclerosis. We determined the of carotid-artery atherosclerosis in relation to both plasma homocysteine concentrations and nutritional determinants hyperhomocysteinemia.
Consumption of soft drinks has been linked to obesity in children and adolescents, but it is unclear whether increases metabolic risk middle-aged individuals.We related the incidence syndrome its components drink consumption participants Framingham Heart Study (6039 person-observations, 3470 women; mean age 52.9 years) who were free baseline syndrome. Metabolic was defined as presence > or = 3 following: waist circumference 35 inches (women) 40 (men); fasting blood glucose 100 mg/dL; serum...
DNA methylation, an essential epigenetic feature of that modulates gene expression and genomic integrity, is catalyzed by methyltransferases use the universal methyl donor S -adenosyl- l -methionine. Methylenetetrahydrofolate reductase (MTHFR) catalyzes synthesis 5-methyltetrahydrofolate (5-methylTHF), for methionine from homocysteine precursor In present study we sought to determine effect folate status on methylation with emphasis interaction common C677T mutation in MTHFR gene. A liquid...
OBJECTIVE—The aim of this study was to examine the relation between carbohydrate-related dietary factors, insulin resistance, and prevalence metabolic syndrome in Framingham Offspring Cohort. RESEARCH DESIGN AND METHODS—We examined cross-sectional associations 2,834 subjects at fifth examination (1991–1995) Study. Homeostasis model assessment resistance (HOMA-IR) calculated using following formula (fasting plasma × glucose)/22.5. The defined National Cholesterol Education Program criteria....
The increased prevalence of osteoporosis among people with homocystinuria suggests that a high serum homocysteine concentration may weaken bone by interfering collagen cross-linking, thereby increasing the risk osteoporotic fracture. We examined association between total and hip fracture in men women enrolled Framingham Study.We studied 825 1174 women, ranging age from 59 to 91 years, whom blood samples had been obtained 1979 1982 measure plasma homocysteine. participants our study were...
Because vitamin D deficiency is associated with a variety of chronic diseases, understanding the characteristics that promote in otherwise healthy adults could have important clinical implications. Few studies relating to obesity included direct measures adiposity. Furthermore, degree which metabolic traits after adjusting for adiposity unclear.We investigated relations serum 25-hydroxyvitamin (25[OH]D) concentrations indexes cardiometabolic risk 3,890 nondiabetic individuals; 1,882 had...
Abstract Nationwide fortification of enriched uncooked cereal grains with folic acid began in the United States and Canada 1996 1997, respectively, became mandatory 1998. The rationale was to reduce number births complicated by neural tube defects. Concurrently, experienced abrupt reversals downward trend colorectal cancer (CRC) incidence that two countries had enjoyed preceding decade: absolute rates CRC increase (United States) 1998 (Canada), peaked 2000 have continued exceed pre-1996/1997...
Background: Total homocysteine levels are associated with arteriosclerotic outcomes. Objective: To determine whether total predict incident stroke in elderly persons. Design: Prospective population-based cohort study 9.9 years of follow-up. Setting: Framingham, Massachusetts. Patients: 1947 Framingham Study participants (1158 women and 789 men; mean age ± SD, 70 7 years). Measurements: Baseline 9.9-year incidence. Results: The quartiles nonfasting were as follows: quartile 1, 4.13 to 9.25...