A5048669225- Ovarian function and disorders
- SARS-CoV-2 and COVID-19 Research
- Reproductive Biology and Fertility
- COVID-19 Clinical Research Studies
- Cancer Risks and Factors
- Pharmaceutical and Antibiotic Environmental Impacts
- Nutritional Studies and Diet
- Endometrial and Cervical Cancer Treatments
- Diabetes and associated disorders
- Long-Term Effects of COVID-19
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Estrogen and related hormone effects
- Growth Hormone and Insulin-like Growth Factors
- Natural Antidiabetic Agents Studies
- Animal Virus Infections Studies
- Pancreatic function and diabetes
- Phytoestrogen effects and research
- SARS-CoV-2 detection and testing
- Diet and metabolism studies
- Vitamin D Research Studies
- Insect and Pesticide Research
- Immunotherapy and Immune Responses
- HIV/AIDS drug development and treatment
- Tea Polyphenols and Effects
Newcastle Dental Hospital
2024
Manchester Royal Infirmary
2024
UConn Health
2024
Indiana University – Purdue University Indianapolis
2020-2022
Augusta University
2022
Rockefeller University
2016-2021
Quinnipiac University
2017-2020
Indianapolis Zoo
2020
Moffitt Cancer Center
2017
Howard Hughes Medical Institute
2016
During the coronavirus disease-2019 (COVID-19) pandemic, severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has led to infection of millions people and claimed hundreds thousands lives. The entry virus into cells depends on receptor-binding domain (RBD) spike (S) protein SARS-CoV-2. Although there is currently no vaccine, it likely that antibodies will be essential for protection. However, little known about human antibody response SARS-CoV-21–5. Here we report 149...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 deaths to date. Infection associated with the development of variable levels antibodies neutralizing activity, which can protect against infection in animal models1,2. Antibody decrease time, but, our knowledge, nature quality memory B cells that would be required produce upon reinfection not been examined. Here we report on humoral response a cohort 87 assessed at...
Here we report on the antibody and memory B cell responses of a cohort 20 volunteers who received Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) vaccine against SARS-CoV-21-4. Eight weeks after second injection vaccine, showed high levels IgM IgG anti-SARS-CoV-2 spike protein (S) receptor-binding-domain (RBD) binding titre. Moreover, plasma neutralizing activity relative numbers RBD-specific cells vaccinated were equivalent to those individuals had recovered from natural infection5,6....
Abstract Background: Few studies have evaluated the combined impact of following recommended lifestyle behaviors on cancer, cardiovascular disease (CVD) and all-cause mortality, most included tobacco avoidance. Because 80% Americans are never or former smokers, it is important to consider other behaviors. Methods: In 1992 1993, 111,966 nonsmoking men women in Cancer Prevention Study-II Nutrition Cohort completed diet questionnaires. A score ranging from 0 8 points was computed reflect...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 deaths to date. Infection associated with development of variable levels antibodies neutralizing activity that can protect against infection in animal models. Antibody decrease time, but the nature quality memory B cells would be called upon produce re-infection not been examined. Here we report on humoral response a cohort 87 assessed at 1.3 6.2 months after...
To date severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected over 100 million individuals resulting in two deaths. Many vaccines are being deployed to prevent coronavirus disease 2019 (COVID-19) including novel mRNA-based 1,2 . These elicit neutralizing antibodies and appear be safe effective, but the precise nature of elicited is not known 3–6 Here we report on antibody memory B cell responses a cohort 20 volunteers who received either Moderna (mRNA-1273) or...
Abstract Epidemiologic studies unequivocally show that greater body mass increases the risk of endometrial cancer, but whether varies by use postmenopausal hormone therapy (HT), location fat deposition, or cancer subtype is still unclear. We examined these associations among 33,436 women in Cancer Prevention Study II Nutrition Cohort, who completed questionnaires on diet, lifestyle, and medical history at baseline 1992. A total 318 cases were eligible through June 2003. Cox-proportional...
Abstract During the COVID-19 pandemic, SARS-CoV-2 infected millions of people and claimed hundreds thousands lives. Virus entry into cells depends on receptor binding domain (RBD) spike protein (S). Although there is no vaccine, it likely that antibodies will be essential for protection. However, little known about human antibody response to 1–5 . Here we report 149 convalescent individuals. Plasmas collected an average 39 days after onset symptoms had variable half-maximal neutralizing...
Background Additional forms of pre-exposure prophylaxis are needed to prevent HIV-1 infection. 3BNC117 and 10–1074 broadly neutralizing anti-HIV-1 antibodies that target non-overlapping epitopes on the envelope. We investigated safety, tolerability, pharmacokinetics, immunogenicity intravenous administration combination in healthy adults. Methods This randomized, double-blind, placebo-controlled, single center, phase 1 study enrolled adults aged 18–65 years receive one infusion immediately...
Abstract Factors influencing circulating estrogen levels, insulin‐mediated pathways or energy balance through obesity‐related mechanisms, such as physical activity, have been proposed potential risk factors for endometrial cancer. We examined measures of activity in relation to cancer the American Cancer Society Prevention Study II Nutrition Cohort, a prospective study incidence and mortality, using information obtained at baseline 1992. From 1992 2003, 466 incident cancers were identified...
Abstract Introduction Vitamin D status measured during adulthood has been inversely associated with breast cancer risk in some, but not all, studies. hypothesized to prevent through genomic and non-genomic actions cell-cycle regulation. Methods A subset (n = 21,965) of female participants from the prospective Cancer Prevention Study-II (CPS-II) Nutrition Cohort provided a blood sample 1998-2001 were followed 2005. We serum 25-hydroxyvitamin (25(OH)D) 516 verified incident cases controls,...
Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism, oligo-anovulation, polycystic ovaries and metabolic syndrome. Many researchers reported that PCOS often starts menarche in adolescents. Presently available animal model focuses on ovarian but not features of PCOS. Therefore, we hypothesized high-fat diet feeding to pre-pubertal female rats results both reproductive Pre-pubertal were divided into two groups: group I received normal pellet II (HFD). In the letrozole study,...
Although oxidative stress is implicated in colorectal carcinogenesis, human studies on associations of individual prooxidants and antioxidants with cancer (CRC) have been inconclusive. We incorporated environmental factors known to affect into 4 balance scores (OBS) investigated their CRC the Cancer Prevention Study II Nutrition Cohort. During 1999–2009, a total 1,109 incident cases were identified among 80,063 participants Cohort who had completed detailed questionnaires. Four OBS different...
Abstract Epigallocatechin-3-gallate (EGCG) is a candidate therapeutic for Down syndrome (DS) phenotypes based on in vitro inhibition of DYRK1A, triplicated gene product Trisomy 21 (Ts21). Consumption green tea extracts containing EGCG improved some cognitive and behavioral outcomes DS mouse models humans with Ts21. In contrast, treatment pure did not improve neurobehavioral phenotypes. This study tested the hypothesis that 200 mg/kg/day EGCG, given via oral gavage, would skeletal Ts65Dn...
Abstract Background Rheumatoid arthritis is the most common cause of disability, affecting 0.3–1% adult population worldwide. The latex Calotropis procera possesses potent anti-inflammatory as well analgesic properties. In light above facts, present study was designed to evaluate anti-arthritic activity in complete Freund's adjuvant (CFA)-induced Wistar albino rats. Complete injected into left hind paw on day 0, and treatment prednisolone given from 0 28. Various biochemical, hematological...
Bone abnormalities affect all individuals with Down syndrome (DS) and are linked to abnormal expression of DYRK1A , a gene found in three copies people DS Ts65Dn model mice. Previous work male mice demonstrated that both genetic normalization Dyrk1a treatment ~9 mg/kg/day Epigallocatechin-3-gallate (EGCG), the main polyphenol green tea putative inhibitor, improved some skeletal deficits. Because EGCG mostly trabecular deficits, we hypothesized increasing dosage length administration would...
Case-control studies support a lower risk of endometrial cancer associated with greater vegetable consumption but not fruit consumption. One prospective study suggested an inverse association fruits and vegetables combined. The authors examined associations for separately among women in the American Cancer Society's Prevention Study II Nutrition Cohort. After exclusions, 41,400 postmenopausal completed questionnaire on diet, lifestyle, medical history at baseline 1992–1993. Information diet...