A5009437173- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Viral gastroenteritis research and epidemiology
- Glycosylation and Glycoproteins Research
- Complement system in diseases
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Advanced biosensing and bioanalysis techniques
- Job Satisfaction and Organizational Behavior
- Biosimilars and Bioanalytical Methods
- Customer Service Quality and Loyalty
- Hydrological Forecasting Using AI
- Emotional Labor in Professions
- Water Quality Monitoring Technologies
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Fish Ecology and Management Studies
- HIV/AIDS Research and Interventions
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS drug development and treatment
Ministry of Ecology and Environment
2024
Dartmouth College
2017-2021
Adimab (United States)
2020
Yuanpei University
2009
Seeking broad protection As scientists develop therapeutic antibodies and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of emergent coronaviruses makes it important to also identify broadly protective antibodies. Wec et al. isolated characterized hundreds viral spike protein SARS-CoV-2 from memory B cells a survivor 2003 outbreak caused by related coronavirus, SARS-CoV. In both these viruses, facilitated entry binding angiotensin-converting enzyme...
Background Additional forms of pre-exposure prophylaxis are needed to prevent HIV-1 infection. 3BNC117 and 10–1074 broadly neutralizing anti-HIV-1 antibodies that target non-overlapping epitopes on the envelope. We investigated safety, tolerability, pharmacokinetics, immunogenicity intravenous administration combination in healthy adults. Methods This randomized, double-blind, placebo-controlled, single center, phase 1 study enrolled adults aged 18–65 years receive one infusion immediately...
The Fc Array is a multiplexed assay that assesses the domain characteristics of antigen-specific antibodies with potential to evaluate up 500 antigen specificities simultaneously. Antigen-specific are captured on antigen-conjugated beads and their functional capacity probed via an array Fc-binding proteins including antibody subclassing reagents, Fcγ receptors, complement proteins, lectins. Here we present results optimization formal qualification Array, performed in compliance Good Clinical...
The impact of inactivated polio vaccines (IPVs) on intestinal mucosal immune responses to live poliovirus is poorly understood. In a 2014 phase 2 clinical trial, Panamanian infants were immunized at 6, 10, and 14 weeks age with bivalent oral vaccine (bOPV) randomized receive either novel monovalent high-dose type 2–specific IPV (mIPV2HD) or standard trivalent weeks. Infants challenged 18 (mOPV2). Infants' during the 3 following challenge investigated by measuring type-specific neutralization...
Broadly protective vaccines against known and pre-emergent coronaviruses are urgently needed. Critical to their development is a deeper understanding of cross-neutralizing antibody responses induced by natural human coronavirus (HCoV) infections. Here, we mined the memory B cell repertoire convalescent SARS donor identified 200 SARS-CoV-2 binding antibodies that target multiple conserved sites on spike (S) protein. A large proportion display high levels somatic hypermutation cross-react with...
While antiretroviral therapy (ART) has effectively revolutionized HIV care, the virus is never fully eliminated. Instead, immune dysfunction, driven by persistent non-specific activation, ensues and progressively leads to premature immunologic aging. Current biomarkers monitoring changes encompass generic inflammatory biomarkers, that may also change with other infections or disease states, precluding antigen-specific of HIV-infection associated in disease. Given our growing appreciation...
Customer relationship management (CRM) is one of the most popular strategies for an organization to satisfy its customers and obtain growth profits. Much attention research date, however, has been paid strategy, implementation, performance, with people dimension in CRM being under-researched. This study attempts investigate importance people-driven processes organizations identify factors affecting effectiveness processes. A multiple case approach was applied in-depth interviews were...
The ability to detect, quantify, and interrogate the properties of immune responses raised against biological therapeutics is not only important our understanding these molecules, but also their success in clinic. A tiered assay approach identify presence, specificity, titer anti-drug antibody (ADA) has been adopted as a gold standard by industry leaders, FDA, EMA. In order support pre-clinical clinical trials, assays must be standardized, performance sufficiently characterized ensure...
Human immunodeficiency virus type 1 (HIV-1) infection remains a major public health threat due to its incurable nature and the lack of highly efficacious vaccine. The RV144 vaccine trial is only clinical study date that demonstrated significant but modest decrease in HIV risk. To improve HIV-1 immunogenicity efficacy, we recently evaluated pox-protein vaccination using next generation liposome-based adjuvant, Army Liposomal Formulation adsorbed aluminum (ALFA), rhesus monkeys observed 90%...