A5044581351- Immune Cell Function and Interaction
- Computational Drug Discovery Methods
- Gene Regulatory Network Analysis
- Calcium signaling and nucleotide metabolism
- T-cell and B-cell Immunology
- Peroxisome Proliferator-Activated Receptors
- Helicobacter pylori-related gastroenterology studies
- Adenosine and Purinergic Signaling
- Bioinformatics and Genomic Networks
- vaccines and immunoinformatics approaches
- Gene expression and cancer classification
- Immunotherapy and Immune Responses
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- Malaria Research and Control
- Cell Image Analysis Techniques
- Influenza Virus Research Studies
- Epigenetics and DNA Methylation
- Galectins and Cancer Biology
- Single-cell and spatial transcriptomics
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Digestive system and related health
- Receptor Mechanisms and Signaling
Frederick National Laboratory for Cancer Research
2021-2024
United States Army Medical Research and Development Command
2020-2022
Telemedicine & Advanced Technology Research Center
2020-2022
Henry M. Jackson Foundation
2020-2022
The University of Texas Health Science Center at Houston
2016-2020
Integrated BioTherapeutics (United States)
2018
Virginia Tech
2010-2017
Biocom
2016-2017
Luye Pharma (China)
2016
Scientific and Technological Research Council of Turkey
2015
Pomegranate fruit presents strong anti-inflammatory, antioxidant, antiobesity, and antitumoral properties, thus leading to an increased popularity as a functional food nutraceutical source since ancient times. It can be divided into three parts: seeds, peel, juice, all of which seem have medicinal benefits. Several studies investigate its bioactive components means associate them with specific beneficial effect develop future products therapeutic applications. Many effects are related the...
Abstract To enable personalized cancer treatment, machine learning models have been developed to predict drug response as a function of tumor and features. However, most algorithm development efforts relied on cross-validation within single study assess model accuracy. While an essential first step, biological data set typically provides overly optimistic estimate the prediction performance independent test sets. provide more rigorous assessment generalizability between different studies, we...
Abscisic acid (ABA) has shown efficacy in the treatment of diabetes and inflammation; however, its molecular targets mechanisms action underlying immunomodulatory effects remain unclear. This study investigates role peroxisome proliferator-activated receptor γ (PPAR γ) lanthionine synthetase C-like 2 (LANCL2) as for ABA. We demonstrate that ABA increases PPAR reporter activity RAW 264.7 macrophages ppar expression vivo, although it does not bind to ligand-binding domain γ. LANCL2 knockdown...
Differentiation of CD4+ T cells into effector or regulatory phenotypes is tightly controlled by the cytokine milieu, complex intracellular signaling networks and numerous transcriptional regulators. We combined experimental approaches computational modeling to investigate mechanisms controlling differentiation plasticity in gut mice. Our model encompasses major pathways involved cell helper 1 (Th1), Th2, Th17 induced (iTreg). efforts predicted a critical role for peroxisome...
Malaria-071, a controlled human malaria infection trial, demonstrated that administration of three doses RTS,S/AS01 vaccine given at one-month intervals was inferior to delayed fractional dose (DFD) schedule (62.5% vs 86.7% protection, respectively). To investigate the underlying immunologic mechanism, we analyzed B and T peripheral follicular helper cell (pTfh) responses. Here, show protection in both study arms associated with early induction functional IL-21-secreting circumsporozoite...
SZGR 2.0 is a comprehensive resource of candidate variants and genes for schizophrenia, covering genetic, epigenetic, transcriptomic, translational many other types evidence. By systematic review curation multiple lines evidence, we included almost all that have ever been reported to be associated with schizophrenia. In particular, collected ∼4200 common in genome-wide association studies, ∼1000 de novo mutations discovered by large-scale sequencing family samples, 215 spanning rare...
Background Treatments for inflammatory bowel disease (IBD) are modestly effective and associated with side effects from prolonged use. As there is no known cure IBD, alternative therapeutic options needed. Peroxisome proliferator-activated receptor-gamma (PPARγ) has been identified as a potential target novel therapeutics against IBD. For this project, compounds were screened to identify naturally occurring PPARγ agonists means anti-inflammatory experimental assessment of efficacy....
Background There is an inverse secular trend between the incidence of obesity and gastric colonization with Helicobacter pylori, a bacterium that can affect secretion hormones relate to energy homeostasis. H. pylori strains carry cag pathogenicity island (PAI) interact more intimately epithelial cells trigger extensive host responses than cag− strains. We hypothesized differing in PAI status exert distinct effects on metabolic inflammatory phenotypes. Methodology/Principal Findings To test...
Background Lanthionine synthetase component C-like protein 2 (LANCL2) is a member of the eukaryotic lanthionine C-Like family involved in signal transduction and insulin sensitization. Recently, LANCL2 target for binding signaling abscisic acid (ABA), plant hormone with anti-diabetic anti-inflammatory effects. Methodology/Principal Findings The goal this study was to determine role as potential therapeutic developing novel drugs nutraceuticals against inflammatory diseases. Previously, we...
Computational techniques are becoming increasingly powerful and modeling tools for biological systems of greater needs. Biological inherently multiscale, from molecules to tissues nano-seconds a lifespan several years or decades. ENISI MSM integrates multiple technologies understand immunological processes signaling pathways within cells lesion formation at the tissue level. This paper examines summarizes technical details ENISI, its initial version latest cutting-edge...
Mutations at the ligand binding sites (LBSs) can influence protein structure stability, affinity with small molecules, and drug resistance in cancer patients. Our recent analysis revealed that residues had a significantly higher mutation rate than other parts of protein. Here, we built mutLBSgeneDB (mutated Ligand Binding Site gene DataBase) available http://zhaobioinfo.org/mutLBSgeneDB We collected curated over 2300 genes (mutLBSgenes) having ∼12 000 somatic mutations ∼10 LBSs across 16...
Nucleotide-binding domain and leucine-rich repeat containing (NLR) family are intracellular sentinels of cytosolic homeostasis that orchestrate immune inflammatory responses in infectious immune-mediated diseases. NLRX1 is a mitochondrial-associated NOD-like receptor involved the modulation metabolic responses. This study utilizes molecular docking approaches to investigate structure experimentally assesses binding naturally occurring compounds from several natural product lipid databases....
Modeling of the immune system - a highly non-linear and complex requires practical efficient data analytic approaches. The is composed heterogeneous cell populations hundreds types, such as neutrophils, eosinophils, macrophages, dendritic cells, T B cells. Each type diverse can be further differentiated into subsets with unique overlapping functions. For example, CD4+ cells Th1, Th2, Th17, Th9, Th22, Treg, Tfh, well Tr1. subset plays different roles in system. To study molecular mechanisms...
Biological systems span several orders of magnitude in space and time from intracellular pathways to tissue-level processes. Many studies focus on molecular level events while other cellular tissue interactions. The immune system is highly complex dynamic, encompassing hierarchical interactions with dimensions ranging nanometers meters scales nanoseconds years. To comprehensively model immunological processes computationally, multi-scale models are needed. However, the lack modeling tools...
Immune responses to Helicobacter pylori are orchestrated through complex balances of host-bacterial interactions, including inflammatory and regulatory immune across scales that can lead the development gastric disease or promotion beneficial systemic effects. While inflammation in response bacterium has been reasonably characterized, pathways contribute preventing events during H. infection incompletely understood. To aid this effort, we have generated a computational model incorporating...
Broad-based, host-targeted therapeutics have the potential to ameliorate viral infections without inducing antiviral resistance. We identified lanthionine synthetase C-like 2 (LANCL2) as a new therapeutic target for immunoinflammatory diseases. To examine efficacy of oral NSC61610 administration on influenza, we infected C57BL/6 mice with influenza A H1N1pdm virus and evaluated influenza-related mortality, lung inflammatory profiles, pulmonary histopathology. Oral treatment ameliorates...
Human immunodeficiency virus type 1 (HIV-1) infection remains a major public health threat due to its incurable nature and the lack of highly efficacious vaccine. The RV144 vaccine trial is only clinical study date that demonstrated significant but modest decrease in HIV risk. To improve HIV-1 immunogenicity efficacy, we recently evaluated pox-protein vaccination using next generation liposome-based adjuvant, Army Liposomal Formulation adsorbed aluminum (ALFA), rhesus monkeys observed 90%...