A5058888863- Inflammatory Bowel Disease
- Immune Cell Function and Interaction
- Calcium signaling and nucleotide metabolism
- Tuberculosis Research and Epidemiology
- Helicobacter pylori-related gastroenterology studies
- Pharmacological Effects of Natural Compounds
- Microscopic Colitis
- Veterinary medicine and infectious diseases
- Pomegranate: compositions and health benefits
- Adenosine and Purinergic Signaling
- Acute Lymphoblastic Leukemia research
- IL-33, ST2, and ILC Pathways
- Peroxisome Proliferator-Activated Receptors
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Pharmaceutical studies and practices
- T-cell and B-cell Immunology
- Hops Chemistry and Applications
- Clinical Nutrition and Gastroenterology
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- Sesame and Sesamin Research
- Gut microbiota and health
- Machine Learning in Healthcare
Integrated BioTherapeutics (United States)
2016-2020
Virginia Tech
2009-2018
Biocom
2016-2018
Virginia–Maryland College of Veterinary Medicine
2013-2015
Immunité et Cancer
2013
Unité de Nutrition Humaine
2005
Iowa State University
2000-2002
Abstract BACKGROUND: Pomegranate seed oil is predominantly composed of triglycerides containing unsaturated fatty acids, including high levels conjugated linolenic acids (CLnAs). The major CLnA component, punicic acid, known to possess biological activity. Consequently, it desirable obtain a detailed characterisation pomegranate acid profiles, molecules potentially co‐eluting with such as jacaric acid. RESULTS: Conjugated profiles commercial sample cold pressed were characterised in detail...
Interactions among the gut microbiome, dysregulated immune responses, and genetic factors contribute to pathogenesis of inflammatory bowel disease (IBD). Nlrx1-/- mice have exacerbated severity, colonic lesions, increased markers. Global transcriptomic analyses demonstrate enhanced mucosal antimicrobial defense response, chemokine cytokine expression, epithelial cell metabolism in colitic compared wild-type (WT) mice. Cell-specificity studies using cre-lox that loss NLRX1 intestinal cells...
Abstract Inflammatory bowel disease (IBD) is a complex autoimmune with dysfunction in pattern-recognition responses, including within the NLR family. Nucleotide-binding oligomerization domain, leucine rich repeat containing X1 (NLRX1) unique regulatory and anti-inflammatory functions resulting protection from IBD mouse models. NX-13 an orally active, gut-restricted novel drug candidate that selectively targets activates NLRX1 pathway locally gut. In vitro vivo efficacy of activation by was...
Nucleotide-binding domain and leucine-rich repeat containing (NLR) family are intracellular sentinels of cytosolic homeostasis that orchestrate immune inflammatory responses in infectious immune-mediated diseases. NLRX1 is a mitochondrial-associated NOD-like receptor involved the modulation metabolic responses. This study utilizes molecular docking approaches to investigate structure experimentally assesses binding naturally occurring compounds from several natural product lipid databases....
Abstract Abscisic acid is a phytohormone found in fruits and vegetables endogenously produced mammals. In humans mice, lanthionine synthetase C-like 2 (LANCL2) has been characterized as the natural receptor for ABA. Herein, we characterize efficacy of fig fruit extract ABA promoting glycemic control. This ABA-enriched extract, at 0.125 µg ABA/kg body weight, improves glucose tolerance, insulin sensitivity fasting blood diet-induced obesity (DIO) db/db mouse models. addition to decreasing...
The spirochaete Brachyspira hyodysenteriae causes swine dysentery, a severe colitis characterized by mucosal enlargement as result of crypt elongation and epithelial necrosis. Most efforts to understand the pathogenesis this disease have focused on aetiological agent its virulence factors. However, host immune response has been considered an important factor in development. Previous research shown that B. induces systemic CD4(+) gammadelta T-cell responses after intramuscular immunization....
Nucleotide-binding oligomerization domain, leucine rich repeat containing X1 (NLRX1) is an emerging therapeutic target for a spectrum of human diseases. NX-13 small molecule designed to and activate NLRX1 induce immunometabolic changes resulting in lower inflammation responses inflammatory bowel disease (IBD). This study investigates the safety seven-day, repeat-dose general toxicity male female Sprague Dawley rats at oral doses 500 1000 mg/kg. Weights, clinical signs, functional...
Summary A vaccine inducing protective immunity to a spirochaete‐induced colitis of pigs predominantly stimulates expansion CD8 + cells in vivo and antigen‐stimulated lymphocyte cultures. cells, however, are rarely considered necessary for protection against extracellular bacterial pathogens. In the present study, recovering from resulting experimental infection with Brachyspira (Serpulina) hyodysenteriae had increased percentages peripheral blood CD4 – (αα‐expressing) compared non‐infected...
Lanthionine synthetase cyclase-like receptor 2 (LANCL2) is a novel therapeutic target for Crohn’s disease (CD). BT-11 small molecule that binds LANCL2, orally active, and has demonstrated efficacy in 3 validated mouse models of colitis at doses as low 8 mg/kg/d. Exploratory experiments evaluated male Harlan Sprague Dawley rats with single oral dose 500 mg/kg 80 mg/kg/d 14 days (n = 10 dosed/group). Treated control were observed behavioral detriments, blood tissues collected clinical...
Immune responses to Helicobacter pylori are orchestrated through complex balances of host-bacterial interactions, including inflammatory and regulatory immune across scales that can lead the development gastric disease or promotion beneficial systemic effects. While inflammation in response bacterium has been reasonably characterized, pathways contribute preventing events during H. infection incompletely understood. To aid this effort, we have generated a computational model incorporating...
Broad-based, host-targeted therapeutics have the potential to ameliorate viral infections without inducing antiviral resistance. We identified lanthionine synthetase C-like 2 (LANCL2) as a new therapeutic target for immunoinflammatory diseases. To examine efficacy of oral NSC61610 administration on influenza, we infected C57BL/6 mice with influenza A H1N1pdm virus and evaluated influenza-related mortality, lung inflammatory profiles, pulmonary histopathology. Oral treatment ameliorates...