A5087379114- Immune Cell Function and Interaction
- Helicobacter pylori-related gastroenterology studies
- Peroxisome Proliferator-Activated Receptors
- Calcium signaling and nucleotide metabolism
- Inflammatory Bowel Disease
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Gene Regulatory Network Analysis
- Microscopic Colitis
- Fatty Acid Research and Health
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Galectins and Cancer Biology
- Immune cells in cancer
- Adenosine and Purinergic Signaling
- Adipose Tissue and Metabolism
- Pharmacological Effects of Natural Compounds
- Inflammatory mediators and NSAID effects
- Influenza Virus Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Veterinary medicine and infectious diseases
- Eosinophilic Esophagitis
- vaccines and immunoinformatics approaches
- Digestive system and related health
Integrated BioTherapeutics (United States)
2016-2020
Virginia Tech
2010-2019
Biocom
2016-2019
National and Kapodistrian University of Athens
2017
University of Tennessee Health Science Center
2017
Geisinger Health System
2017
University of California, Los Angeles
2017
Immunité et Cancer
2013-2016
Virginia–Maryland College of Veterinary Medicine
2014
Virginia BioTechnology Research Park
2013
Pomegranate fruit presents strong anti-inflammatory, antioxidant, antiobesity, and antitumoral properties, thus leading to an increased popularity as a functional food nutraceutical source since ancient times. It can be divided into three parts: seeds, peel, juice, all of which seem have medicinal benefits. Several studies investigate its bioactive components means associate them with specific beneficial effect develop future products therapeutic applications. Many effects are related the...
AbstractObjective: Peroxisome proliferator-activated receptor γ (PPAR γ) is the molecular target for thiazolidinediones (TZDs), a class of synthetic antidiabetic agents. However, naturally occurring agonists PPARs remain largely unknown. Punicic acid (PUA) conjugated linolenic isomer found in pomegrante. The objective this study was to test hypothesis that PUA activates PPAR and thereby ameliorates glucose homeostasis obesity-related inflammation.Methods: ability modulate reporter activity...
Peroxisome proliferator-activated receptor (PPAR) gamma activation has been implicated in the prevention of immunoinflammatory disorders; however, mechanisms regulation effector and regulatory CD4+ T cell functions by endogenously activated PPAR-gamma remain unclear. We have used PPAR-gamma-deficient cells obtained from tissue-specific null mice (i.e., fl/fl; MMTV-Cre+) to investigate role endogenous on (Treg) function. Overall, we show that loss results enhanced Ag-specific proliferation...
Background Inflammatory bowel disease (IBD) therapies are modestly successful and associated with significant side effects. Thus, the investigation of novel approaches to prevent colitis is important. Probiotic bacteria can produce immunoregulatory metabolites in vitro such as conjugated linoleic acid (CLA), a polyunsaturated fatty potent anti-inflammatory This study aimed investigate cellular molecular mechanisms underlying efficacy probiotic using mouse model colitis. Methodology/Principal...
Inflammatory bowel disease (IBD) increases the risk of colorectal cancer. Probiotic bacteria produce immunoregulatory metabolites in vitro such as conjugated linoleic acid (CLA), a polyunsaturated fatty with potent anti-carcinogenic effects. This study aimed to investigate cellular and molecular mechanisms underlying efficacy probiotic mouse models cancer.The immune modulatory VSL#3 CLA were investigated inflammation-driven Colonic specimens collected for histopathology, gene expression flow...
Background and Purpose— The timely diagnosis of stroke at the initial examination is extremely important given disease morbidity narrow time window for intervention. goal this study was to develop a supervised learning method recognize acute cerebral ischemia (ACI) differentiate that from mimics in an emergency setting. Methods— Consecutive patients presenting department with stroke-like symptoms, within 4.5 hours symptoms onset, 2 tertiary care centers were randomized inclusion model. We...
Abscisic acid (ABA) has shown efficacy in the treatment of diabetes and inflammation; however, its molecular targets mechanisms action underlying immunomodulatory effects remain unclear. This study investigates role peroxisome proliferator-activated receptor γ (PPAR γ) lanthionine synthetase C-like 2 (LANCL2) as for ABA. We demonstrate that ABA increases PPAR reporter activity RAW 264.7 macrophages ppar expression vivo, although it does not bind to ligand-binding domain γ. LANCL2 knockdown...
Differentiation of CD4+ T cells into effector or regulatory phenotypes is tightly controlled by the cytokine milieu, complex intracellular signaling networks and numerous transcriptional regulators. We combined experimental approaches computational modeling to investigate mechanisms controlling differentiation plasticity in gut mice. Our model encompasses major pathways involved cell helper 1 (Th1), Th2, Th17 induced (iTreg). efforts predicted a critical role for peroxisome...
Enteroaggregative Escherichia coli (EAEC) is increasingly recognized as a major cause of diarrheal disease globally. In the current study, we investigated impact zinc deficiency on host and pathogenesis EAEC. Several outcomes EAEC infection were including weight loss, shedding tissue burden, leukocyte recruitment, intestinal cytokine expression, virulence expression pathogen in vivo. Mice fed protein source defined deficient diet (dZD) had an 80% reduction serum 50% luminal contents bowel...
Abstract Background Peroxisome proliferator-activated receptor γ (PPAR γ) is a nuclear whose activation has been shown to modulate macrophage and T cell-mediated inflammation. The objective of this study was investigate the mechanisms by which deletion PPAR in cells modulates immune cell distribution colonic gene expression severity experimental IBD. Methods flfl; CD4 Cre + (CD4cre) or Cre- (WT) mice were challenged with 2.5% dextran sodium sulfate their drinking water for 0, 2, 7 days. Mice...