A5035876466- Sexual function and dysfunction studies
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Urinary Bladder and Prostate Research
- Hedgehog Signaling Pathway Studies
- Hormonal and reproductive studies
- Health and Medical Education
- melanin and skin pigmentation
- Food composition and properties
- Multiple Myeloma Research and Treatments
- Inflammatory Bowel Disease
- Abdominal Surgery and Complications
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Genomic variations and chromosomal abnormalities
- Chronic Myeloid Leukemia Treatments
- Signaling Pathways in Disease
- Medical research and treatments
- IL-33, ST2, and ILC Pathways
- Cellular transport and secretion
- Single-cell and spatial transcriptomics
- Chromosomal and Genetic Variations
- Trigeminal Neuralgia and Treatments
- Cancer-related gene regulation
- Protein Kinase Regulation and GTPase Signaling
University of California, San Diego
2024
Sanford Consortium for Regenerative Medicine
2024
University of Miami
2017-2021
Sylvester Comprehensive Cancer Center
2017-2021
University of Miami Hospital
2020
Jackson Memorial Hospital
2018
Virginia Tech
2008-2011
Universitat de Vic - Universitat Central de Catalunya
2008
UCLA Medical Center
2006-2008
The Lundquist Institute
2006-2008
The tyrosine kinase receptor c-kit and its ligand KL are required for postnatal development of germ cells, in addition to their role primordial cells. To clarify function, a detailed examination the pattern expression gonads was undertaken. In ovaries, as seen by RNA blot analysis RNase protection assays is relatively high at birth (P0), low from P5 P8, P12 onward. testes all ages. forms present suggest that onward membrane-bound form predominates, while ovary significant amounts both...
Mutations at the murine steel (Sl) locus encoding ligand for c-kit receptor result in defects gametogenesis, hematopoiesis, and melanogenesis, Steel Panda (Slpan) is an allele Sl obtained by X-ray mutagenesis protocol. Slpan /Slpan homozygotes are mildly anemic black-eyed whites with pigmented ears scrotum; females sterile while males fertile. To investigate basis of phenotype mutation, coding region kit (KL) Slpan/Slpan animals was characterized shown to be identical that from +/+ mice. RNA...
To determine whether a long-term single daily oral dose of longer half-life phosphodiesterase-5 (PDE5) inhibitor, tadalafil, has similar effect to that the shorter PDE5 inhibitors sildenafil and vardenafil, can prevent fibrosis resultant corporal veno-occlusive dysfunction (CVOD) occurring after cavernosal nerve (CN) injury.Male rats (10 per group) had either sham operation, unilateral CN resection (CNR) or bilateral CNR, were left untreated given retrolingually 5 mg/kg day tadalafil. After...
Aging-related erectile dysfunction is characterized by a loss of smooth muscle cells (SMCs) and fibrosis in the corpora cavernosa, functionally corporal veno-occlusive (CVOD). Phosphodiesterase 5 (PDE5A) inhibitors, part via upregulating inducible nitric oxide synthase (NOS2A), have antifibrotic properties penile tissues. We aimed to determine whether aged rat chronic long-term treatment with sildenafil ameliorates SMC fibrosis, stimulates NOS2A induction, corrects associated CVOD. Aged male...
The c-kit receptor and its cognate ligand, KL, are encoded at the white spotting locus (W) steel (Sl) of mouse, respectively. Sl W mutations affect same cellular targets in melanogenesis, gametogenesis hematopoiesis during embryonic development adult life. is expressed mutations, whereas KL microenvironment these targets. however, also tissues cell types that not including brain. cerebellum contains a small number neural whose developmental origins, pathways migration, synaptic contacts...
It has been extensively described that neuronal differentiation involves the signalling through neurotrophin receptors to a Ras‐dependent mitogen‐activated protein kinase (MAPK) cascade. However, pathways from other neuritogenic factors have not well established. reported cAMP may activate (PKA), and it shown PKA‐mediated stimulation of MAPK pathway regulates only neuritogenesis but also survival. extracellular regulated kinases (ERKs) mediated are sufficient explain all processes which...
Follicular lymphoma (FL) is one of the most frequently diagnosed lymphomas in United States and Europe. The definition basic approach to diagnosis grading FL essentially unchanged recently updated revision World Health Organization (WHO) classification. a biologically histopathologically heterogeneous disease. Although there an improved understanding some variants specific subtypes, are cases whose recognition particularly challenging, either because they have unusual features or represent...
Recently, an unusual subtype of large B-cell lymphoma (LBCL) with distinctive clinicopathologic features has been recognized; it is characterized by involvement bone marrow or without liver and/or spleen, but no lymph node other extranodal sites, usually associated fever, anemia, and hemophagocytic lymphohistiocytosis (HLH). Because this clinical presentation, designated “bone marrow-liver-spleen” (BLS) type LBCL. To date there only one series 11 cases BLS LBCL detailed clinical, pathologic,...
Punicic acid (PUA) is a conjugated linolenic isomer that has shown promise in suppressing gut inflammation. The goal of this study to elucidate the mechanisms by which PUA modulates mucosal immunity and prevents or ameliorates expression peroxisome proliferator‐activated receptor (PPAR) α, γ δ their responsive genes was examined colonic mucosa two mouse models experimental inflammatory bowel disease (IBD). Immune cell‐specific PPAR null, null wild‐type (WT) mice were administered control...
ABSTRACT Recent advances in barcoding technologies have significantly enhanced the scalability of single-cell genomic experiments. However, large-scale experiments are still rare due to high costs, complex logistics, and laborintensive procedures. To facilitate routine application largest scalability, it is critical simplify production use reagents. Here, we introduce AmpliDrop, a technology that initiates process using pool inexpensive single-copy barcodes integrates barcode multiplicity...
The goal of this study was to determine the efficacy dietary fibers in preventing gut inflammation interleukin‐10‐deficient (IL‐10−/−) mice. C57BL/6J wild type mice (n=90) and IL‐10−/− (n=185) were randomly assigned either a control or isocaloric isonitrogenous diets supplemented with PROMITOR™ soluble corn fiber (SCF), STA‐LITE III® polydextrose (PDX), biogum (BG), pullulan, resistant starch‐75 (RS‐75), SGF&BG, RS‐75&BG inulin (4 g fiber/100 diet). On day 47 spleen, mesenteric lymph...
You have accessJournal of UrologyModerated Poster 23, Monday, May 21, 2007, 10:00 am - 12:00 pm1 Apr 2007781: Time Course Corporal Vend-Occlusive Dysfunction (CVOD) Development and Inducible Nitric Oxide Synthase (INOS) Expression in Rat Penile Tissue after Cavernosal Nerve Damage Monica G. Ferrini, Istvan Kovanecz, Sandra Sanchez, Jacob Rajfer, Nestor F. Gonzalez-Cadavid FerriniMonica Ferrini More articles by this author , KovaneczIstvan Kovanecz SanchezSandra Sanchez RajferJacob Rajfer...