A5051521468- Immune Cell Function and Interaction
- HIV Research and Treatment
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Respiratory viral infections research
- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- CAR-T cell therapy research
- HIV/AIDS Research and Interventions
- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- Urinary Tract Infections Management
- Gut microbiota and health
- Nuclear Receptors and Signaling
- Peripheral Neuropathies and Disorders
- Animal Virus Infections Studies
- Neuroblastoma Research and Treatments
- Viral-associated cancers and disorders
- Galectins and Cancer Biology
- Herpesvirus Infections and Treatments
Technion – Israel Institute of Technology
2021-2024
Rockefeller University
2016-2020
Hebrew University of Jerusalem
2010-2017
Howard Hughes Medical Institute
2016
Hadassah Medical Center
2015
Three new potent neutralizing antibodies neutralize autologous HIV-1 strains and contribute to viral control in an controller.
Natural killer (NK) cells mediate innate immune responses against hazardous and are particularly important for the control of human cytomegalovirus (HCMV). NKG2D is a key NK activating receptor that recognizes family stress-induced ligands, including MICA, MICB, ULBP1-6. Notably, most these ligands targeted by HCMV proteins miRNA to prevent killing infected cells. A particular highly prevalent MICA allele, MICA∗008, considered be an HCMV-resistant "escape variant" confers advantage in...
ABSTRACT Today, global attention is focused on two influenza virus strains: the current pandemic strain, swine origin (H1N1-2009), and highly pathogenic avian virus, H5N1. At present, infection caused by H1N1-2009 moderate, with mortality rates of less <1%. In contrast, H5N1 resulted in high rates, ca. 60% infected patients succumb to infection. Thus, one world greatest concerns that will evolve allow an efficient human human-to-human transmission. Natural killer (NK) cells are innate...
Natural killer (NK) cells are innate cytotoxic lymphocytes that specialize in the defense against viral infection and oncogenic transformation. Their action is tightly regulated by signals derived from inhibitory activating receptors; later include proteins such as Cytotoxicity Receptors (NCRs: NKp46, NKp44 NKp30). Among NCRs, NKp46 only receptor has a mouse orthologue named Ncr1. NKp46/Ncr1 also unique marker expressed on NK Lymphoid tissue inducer (LTI) it was implicated control of various...
Natural killer (NK) cells play an essential role in the defense against influenza virus, one of deadliest respiratory viruses known today. The NKp46 receptor, expressed by NK cells, is critical for controlling infections, as influenza-virus-infected are eliminated through recognition viral hemagglutinin (HA) protein NKp46. Here, we describe immune-evasion mechanism that mediated neuraminidase (NA) protein. By using various NA blockers, show removes sialic acid residues from and this leads to...
Antiretroviral therapy controls, but does not cure, HIV-1 infection due to a reservoir of rare CD4
// Alexandra Duev-Cohen 1 , Yotam Bar-On Ariella Glasner Orit Berhani Yael Ophir Francesca Levi-Schaffer 2 Michal Mandelboim 3 and Ofer The Lautenberg Center of General Tumor Immunology, Hebrew University Hadassah Medical School, IMRIC, Jerusalem, Israel Department Pharmacology Experimental Therapeutics, School Pharmacy, Faculty Medicine, Central Virology Laboratory, Ministry Health, Public Health Services, Chaim Sheba Center, Ramat-Gan, Correspondence to: Mandelboim, email: Keywords :...
Genetic deficiencies provide insights into gene function in humans. Here we describe a patient with very rare genetic deficiency of ADAM17. We show that the patient's PBMCs had impaired cytokine secretion response to LPS stimulation, correlating clinical picture severe bacteremia from which suffered. ADAM17 was shown cleave CD16, major NK killer receptor. Functional analysis cells demonstrated his express normal levels activating receptors and maintain high surface CD16 following mAb...
ABSTRACT Aim To evaluate the impact of macrophage depletion on bone loss and inflammatory responses in a mouse model peri‐implantitis, assessing potential as therapeutic strategy. Materials Methods Using 6‐week‐old male C57BL/6 mice, peri‐implantitis was induced by placing silk ligature around osteointegrated dental implants. Mice were divided into three groups: Healthy control (Healthy group); with liposomal phosphate‐buffered saline (PBS clodronate for (CLOD group). Two weeks after...
Natural killer (NK) cells are innate immune able to rapidly kill virus-infected and tumor cells. Two NK cell populations found in the blood; majority (90%) expresses CD16 receptor also express CD56 protein intermediate levels (CD56Dim CD16Pos) while remaining 10% negative high (CD56Bright CD16Neg). reside some tissues traffic various infected organs through usage of different chemokines chemokine receptors. Kaposi's sarcoma-associated herpesvirus (KSHV) is a human virus that has developed...
Significance The ability of HIV-1 to rapidly develop resistance against various therapeutics remains a roadblock finding cure. Here we propose that nanoparticle-based mimic target cells by presenting clusters CD4, the receptor, could prevent effective viral escape. We show CD4 multimerization on nanoparticle dramatically enhanced neutralization potency and breadth compared with conventional CD4-based reagents present only one or two copies CD4. nanoparticles neutralized range diverse...
Abstract Global pandemics caused by influenza or coronaviruses cause severe disruptions to public health and lead high morbidity mortality. There remains a medical need for vaccines against these pathogens. CMV (cytomegalovirus) is β-herpesvirus that induces uniquely robust immune responses in which remarkably large populations of antigen-specific CD8 + T cells are maintained lifetime. Hence, has been proposed investigated as novel vaccine vector expressing antigenic peptides proteins elicit...
Targeting multiple viral proteins is pivotal for sustained suppression of highly mutable viruses. In recent years, broadly neutralizing antibodies that target the influenza virus hemagglutinin and neuraminidase glycoproteins have been developed, antibody monotherapy has tested in preclinical clinical studies to treat or prevent infection. However, impact dual neutralization on course infection, as well its therapeutic potential, not thoroughly tested. For this purpose, we generated a...
Cells in our body can induce hundreds of antiviral genes following virus sensing, many which remain largely uncharacterized. CEACAM1 has been previously shown to be induced by various innate systems; however, the reason for such tight integration sensing systems was not apparent. Here, we show that is detection HCMV and influenza viruses their respective DNA RNA sensors, IFI16 RIG-I. This induction mediated IRF3, bound an ISRE element present human, but mouse, promoter. Furthermore,...
CXCR3 is a chemokine receptor with three ligands: CXCL9, CXCL10 and CXCL11. We report that in addition to attracting CXCR3+ T cells tumor sites key role of CXCL9 inducing self-feeding feedback loop accelerates effector/cytotoxic activities both CD4+ CD8+ while downregulating immunoregulatory protein TIM3. CXCR3KO mice displayed markedly reduced response anti-PD-1 anti-CTLA-4 therapy. Results from panel vivo ex 3D models imply that, beyond driving into T-cell exhaustion, major PD-1 CTLA-4...
The recent approval of oncolytic virus for therapy melanoma patients has increased the need precise evaluation mechanisms by which viruses affect tumor growth. Here we show that human NK cell-activating receptor NKp46 and orthologous mouse protein NCR1 recognize reovirus sigma1 in a sialic-acid-dependent manner. We identify sites NKp46/NCR1 binding to leads cell activation vitro Finally, demonstrate is essential reovirus-based vivo Collectively, have identified as novel ligand demonstrated...
Natural killer (NK) cells are capable of killing various pathogens upon stimulation activating receptors. Human metapneumovirus (HMPV) is a respiratory virus, which was discovered in 2001 and responsible for acute tract infection infants children worldwide. HMPV very common, infecting around 70% all under the age five. Under immune suppressive conditions, can be fatal. Not much known on how NK respond to HMPV. In this study, using reporter assays NK‐cell cytotoxicity performed with human...
Abstract Objectives The mRNA-based COVID-19 vaccines are now employed globally and have shown high efficacy in preventing SARS-CoV-2 infection. However, less is known about the vaccine immune-suppressed individuals. This study sought to explore whether humoral immunity BNT162b2 altered RA patients treated with Janus kinase inhibitors by analysing their antibodies titre, neutralization activity B cell responses. Methods We collected plasma samples from 12 who were received two doses of...