A5052306758- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
- Galectins and Cancer Biology
- Full-Duplex Wireless Communications
- Cytomegalovirus and herpesvirus research
- Toxin Mechanisms and Immunotoxins
- Signaling Pathways in Disease
- CAR-T cell therapy research
Hebrew University of Jerusalem
2013-2016
The use of checkpoint inhibitors has revolutionized cancer therapy. Unfortunately, these therapies often cause immune-related adverse effects, largely due to a lack tumor specificity.We stained human natural killer cells using fusion proteins composed the extracellular portion various markers fused Fc IgG1, and identified Nectin4 as novel TIGIT ligand. Next, we generated blocking antibody demonstrated its efficacy inhibitor in killing assays vivo.We identify be ligand TIGIT. We showed that,...
MHC class I molecules, in addition to their role specific activation of the CTL adaptive immune system, function also as main ligands for NK cell inhibitory receptors, which prevent cells from killing normal, healthy cells. proteins are divided into classical and nonclassical proteins. The former group consists hundreds HLA-A, B, C alleles, universally expressed, whereas several alleles latter group, such HLA-G, manifest a restricted expression pattern. Despite important played by these...
// Alexandra Duev-Cohen 1 , Yotam Bar-On Ariella Glasner Orit Berhani Yael Ophir Francesca Levi-Schaffer 2 Michal Mandelboim 3 and Ofer The Lautenberg Center of General Tumor Immunology, Hebrew University Hadassah Medical School, IMRIC, Jerusalem, Israel Department Pharmacology Experimental Therapeutics, School Pharmacy, Faculty Medicine, Central Virology Laboratory, Ministry Health, Public Health Services, Chaim Sheba Center, Ramat-Gan, Correspondence to: Mandelboim, email: Keywords :...
Natural killer (NK) cells are innate immune able to rapidly kill virus-infected and tumor cells. Two NK cell populations found in the blood; majority (90%) expresses CD16 receptor also express CD56 protein intermediate levels (CD56Dim CD16Pos) while remaining 10% negative high (CD56Bright CD16Neg). reside some tissues traffic various infected organs through usage of different chemokines chemokine receptors. Kaposi's sarcoma-associated herpesvirus (KSHV) is a human virus that has developed...
Polyomaviruses are a diverse family of viruses which prevalent in the human population. However, interactions these with immune system not well characterized. We have previously shown that two polyomaviruses, JC and BK, use an identical microRNA to evade attack by Natural Killer (NK) cells. showed this viral suppresses ULBP3 expression, stress induced ligand for killer receptor NKG2D. Here we show Simian Virus 40 (SV40) also evades NK cell through down regulation another stress-induced...
NK cells are innate immune lymphocytes that express a vast repertoire of germ-line encoded receptors for target recognition. These include inhibitory and activating proteins, among the latter which is CD16, low affinity binding Fc receptor. Here, we show human expand in response to stimulation with various tumor cell lines. We further demonstrate tumor-derived expansion accompanied by rapid, cell-dependent, changes CD16 expression levels. expanded EBV-transformed line 721.221, shed therefore...
Natural Killer (NK) cells are innate immune lymphocytes specializing in recognition and killing of tumors pathogens, using an array activating inhibitory receptors. NK inhibition is mediated by a large repertoire receptors, whereas limited number cell receptors execute activation. The ligands recognized the stress-induced, pathogen derived, tumor specific even self ligands. However, full spectrum that control activity remains uncharacterized. Here we demonstrate Paired Ig-Like type 2...