A5004524729- Bacterial biofilms and quorum sensing
- bioluminescence and chemiluminescence research
- Antimicrobial Resistance in Staphylococcus
- Dermatology and Skin Diseases
- Bacillus and Francisella bacterial research
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Autoimmune Bullous Skin Diseases
- Poxvirus research and outbreaks
- Eosinophilic Disorders and Syndromes
- COVID-19 and healthcare impacts
- Herpesvirus Infections and Treatments
- Immune Cell Function and Interaction
- Antibiotic Resistance in Bacteria
- Contact Dermatitis and Allergies
- Chronic Myeloid Leukemia Treatments
- Psoriasis: Treatment and Pathogenesis
- Dermatological and COVID-19 studies
- Systemic Sclerosis and Related Diseases
- Genital Health and Disease
- Infant Health and Development
- Chemotherapy-related skin toxicity
- Listeria monocytogenes in Food Safety
- Pleural and Pulmonary Diseases
- Clostridium difficile and Clostridium perfringens research
New York University
2020-2024
NYU Langone Health
2020
Massachusetts General Hospital
2019
Rockefeller University
2017-2018
Columbia University Irving Medical Center
2018
Columbia University
2018
Princeton University
2013
University of Washington
2013
Quantum dots are an excellent resource for demonstrating quantum phenomena. Two new methods synthesizing presented. Proceeding at relatively low reaction temperatures, these exercises safe and easy to conduct in undergraduate student laboratory. The prepared from the first method exhibited visible luminescence across a broad range of colors. size-dependent spectral properties were examined quantitatively second method. Following this procedure, students advanced chemistry laboratory course...
The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that protection surprisingly extends beyond post-exponential growth the exit from stationary phase when is no longer turned on. Thus, can be considered constitutive protective factor. Deletion resulted decreased ATP levels and growth, despite increased rates...
ABSTRACT Atopic dermatitis (AD) is a prevalent inflammatory skin disease with complex pathogenesis. Both and gut microbiota influence AD, Staphylococcus aureus , in particular, exacerbating the disease. However, relationship between S. colonization skin, whether it affects remains unclear. Using combination of culture-based methods, microbiome analysis, genome sequencing from multiple body sites children without we found that represents major reservoir genetically diverse transmitted to...
The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure lethal concentrations of H 2 O , a crucial host defense against S. . We now report that protection surprisingly extends beyond post-exponential growth the exit from stationary phase when is no longer turned on. Thus, can be considered constitutive protective factor. Deletion resulted decreased ATP levels and growth, despite increased rates respiration or...
In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist V. sensing, which was identified through rational drug design based on native signal. This novel may serve as useful lead compound for control virulence in cholerae.
Palbociclib, a selective cyclin-dependent kinase (CDK) 4/6 inhibitor, is currently under investigation for the treatment of multiple cancers. Here we describe patient with metastatic breast cancer who had Stevens-Johnson syndrome (SJS)-like reaction protracted course after 3 weeks therapy palbociclib. The patient's lesions improved cessation palbociclib and oral cyclosporine. This first report to our knowledge CDK inhibitor associated severe cutaneous reaction.
The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure lethal concentrations of H 2 O , a crucial host defense against S. . We now report that protection surprisingly extends beyond post-exponential growth the exit from stationary phase when is no longer turned on. Thus, can be considered constitutive protective factor. Deletion increased both respiration and fermentation but decreased ATP levels growth,...
Leukemia cutis (LC) is a dermatologic manifestation of leukemia. Its clinical implications for the patient and biological mechanism behind LC are unknown. The oncology community increasingly utilizing mutations to classify number malignancies prognosticate outcomes choose targeted therapies. A single-center, retrospective analysis dermatopathology cases with diagnosis leukemia was performed. Patients genetic testing using Columbia Combined Cancer Panel (a sequencing protocol 467 genes) or...
The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that protection surprisingly extends beyond post-exponential growth the exit from stationary phase when is no longer turned on. Thus, can be considered constitutive protective factor. Deletion increased both respiration and fermentation but decreased ATP levels growth,...
The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure lethal concentrations of H 2 O , a crucial host defense against S. . We now report that protection surprisingly extends beyond post-exponential growth the exit from stationary phase when is no longer turned on. Thus, can be considered constitutive protective factor. Deletion increased both respiration and aerobic fermentation but decreased ATP levels...
We recently described the evolution of a community-acquired methicillin-resistant