A5022143111- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Cutaneous Melanoma Detection and Management
- Urticaria and Related Conditions
- Nail Diseases and Treatments
- Dermatological and Skeletal Disorders
- Cancer and Skin Lesions
- Acne and Rosacea Treatments and Effects
- Genetic and rare skin diseases.
- Nonmelanoma Skin Cancer Studies
- Eosinophilic Disorders and Syndromes
- Skin and Cellular Biology Research
- Autoimmune and Inflammatory Disorders
- Virus-based gene therapy research
- Dermatologic Treatments and Research
- Melanoma and MAPK Pathways
- Hair Growth and Disorders
- Cancer Research and Treatments
- AI in cancer detection
- Inflammatory Myopathies and Dermatomyositis
- Colorectal Cancer Treatments and Studies
- Hidradenitis Suppurativa and Treatments
- Autophagy in Disease and Therapy
- Oral Health Pathology and Treatment
- Hedgehog Signaling Pathway Studies
Legacy Health
2025
New York University
2015-2024
NYU Langone Health
2016-2024
Icahn School of Medicine at Mount Sinai
2023-2024
MBio Diagnostics (United States)
2024
Brigham and Women's Hospital
2022
Harvard University
2022
Sadick Dermatology
2021
Eastern Cooperative Oncology Group
2018-2021
University of North Carolina at Chapel Hill
2019
Abstract Arginine deprivation as an anticancer therapy has historically been met with limited success. The development of pegylated arginine deiminase (ADI-PEG20) renewed interest in for the treatment some cancers. efficacy ADI-PEG20 is directly correlated argininosuccinate synthetase (ASS) deficiency. CWR22Rv1 prostate cancer cells do not express ASS, rate-limiting enzyme synthesis, and are susceptible to vitro. Interestingly, apoptosis by 0.3 μg/mL occurs 96 hours posttreatment caspase...
Abstract Eukaryotic cells can synthesize the non‐essential amino acid arginine from aspartate and citrulline using enzyme argininosuccinate synthetase (ASS). It has been observed that ASS is underexpressed in various types of cancers ASS, for which become auxotrophic. Arginine deiminase (ADI) a prokaryotic metabolizes to found inhibit melanoma hepatoma cancer deficient ASS. We tested hypothesis pancreatic have low expression therefore deprivation by ADI will cell growth. was examined 47...
As more people become vaccinated against the SARS-CoV-2 virus, reports of delayed cutaneous hypersensitivity reactions are beginning to emerge.In this IRB-approved retrospective case series, biopsy specimens potential adverse from Pfizer-BioNTech or Moderna mRNA vaccine were identified and reviewed. Clinical information was obtained through requisition form, referring clinician, medical chart review.Twelve cases included. Histopathological features two injection-site showed a mixed-cell...
Abstract Background Two primary histologic subtypes, superficial spreading melanoma (SSM) and nodular (NM), comprise the majority of all cutaneous melanomas. NM is associated with worse outcomes, which have been attributed to increased thickness at presentation, it widely expected that SSM would exhibit similar behavior once metastasized. Herein, we tested hypothesis subtype an independent predictor survival may impact response treatment in metastatic setting. Methods We examined most recent...
Prostate cancer (PCa) cells undergoing neuroendocrine differentiation (NED) are clinically relevant to the development of relapsed castration-resistant PCa. Increasing evidences show that autophagy involves in (NE) tumors, including To clarify effect on NED, androgen-sensitive PCa LNCaP were examined. Treatment with IL-6 resulted an induction autophagy. In absence androgen, caused even stronger activation Similar result was identified NED induction. Inhibition chloroquine (CQ) markedly...
Abstract Image-based analysis as a rapid method for mutation detection can be advantageous in research or clinical settings when tumor tissue is limited unavailable direct testing. Here, we applied deep convolutional neural network (CNN) to whole slide images of melanomas from 256 patients and developed fully automated model that first selects tumor-rich areas (Area Under the Curve AUC=0.96) then predicts presence mutated BRAF our test set (AUC=0.72) Model performance was cross-validated on...
Prostate cancer, the leading incidence of cancer in American males, is a disease which treatment nonlocalized tumors remains largely unsuccessful. These cancers lose expression an arginine synthesis enzyme, argininosuccinate synthetase (ASS), and are susceptible to deprivation by deiminase (ADI). We show CWR22Rv1 prostate cells ADI caspase-independent manner vitro xenograft model vivo. demonstrate that single amino acid able trigger autophagy. Inhibition autophagy chloroquine siRNA enhances...
Acne vulgaris continues to be a challenge dermatologists and primary care physicians alike. The available treatments reflect the complex multifactorial contributors acne pathogenesis, with topical retinoids as first-line therapy for mild acne, in combination anti-microbials moderate isotretinoin severe nodular acne. Unfortunately, these conventional therapies may not effective against refractory can lead antibiotic resistance, is associated adverse effects. With rise of new technologies...
Patients with alopecia areata (AA) may access a wide range of sources for information about AA, including the recently developed ChatGPT. Assessing quality health provided by these is crucial, as patients are utilizing them in increasing numbers.The aim study was to evaluate appropriateness and accuracy responses common patient questions AA generated ChatGPT.Responses ChatGPT 3.5 4.0 25 addressing concerns were assessed multiple attending dermatologists an academic center accuracy....
Cutaneous lupus erythematosus (CLE) is an autoimmune disease with diverse clinical manifestations, including patchy hair loss resembling alopecia areata (AA). This report describes two cases of CLE presenting as AA mimickers, emphasizing the need to consider in differential diagnosis for loss. Early and accurate crucial effective management preventing scarring alopecia. J Drugs Dermatol. 2025;24(3):324-326. doi:10.36849/JDD.7793R1.
Pyoderma gangrenosum (PG) is a rare, neutrophilic, ulcerative dermatosis without therapeutic gold standard.1 Vegetative PG chronic superficial variant, which more indolent and typically responds well to treatment.1,2 Here we describe patient with 3-year history of uncharacteristically recalcitrant vegetative who responded apremilast.
Direct immunofluorescence (DIF) testing has been an important ancillary tool for the diagnosis of various inflammatory mucocutaneous conditions more than 50 years. Current DIF test panels are based on historical clinical descriptions; few studies have rigorously addressed preanalytical, analytical, and/or postanalytical aspects, and even fewer replicated or validated. Recent unresolved key issues include whether should be triaged truncated indication histopathologic findings. To assess...
Little is known regarding the clinical practice of immunohistochemistry in diagnosis melanoma. We aimed to assess incidence immunostain usage by referring pathologists and dermatopathologists melanoma cases sent for consultative review. As a secondary objective, associations between use specific characteristics were also evaluated.This retrospective review consultation reports referred melanomas at tertiary academic center New York, NY from 2001 2015. Univariate regression analysis was...
Introduction: Coronavirus disease 2019 (COVID-19) has brought teledermatology to the forefront. Understanding patients' experiences will clarify its benefits and limitations. Materials Methods: Patients evaluated through live-interactive at New York University Langone Health March-June 2020 were surveyed. Patient demographics, satisfaction with, preferences between in-person visits across four domains (visit preparation, provider communication, physical examination, treatment plan/follow-up)...
Acquired reactive perforating collagenosis (ARPC) is a type of disorder that often associated with underlying systemic diseases, such as diabetes mellitus, renal failure, or malignancy. Giant variants ARPC may reach up to 2 cm in size and have been reported only handful cases. We present patient giant the setting metastatic breast cancer uncontrolled mellitus.
BACKGROUND While infrequent, nodal metastases in cutaneous squamous cell carcinoma (cSCC) can result death from disease. Identification of those at risk for is key to improved prognostication and treatment. OBJECTIVE To review metastatic cSCC the study institution. METHODS AND MATERIALS Sixteen patients with were identified New York University Dermatologic Associates Cancer 1998 2013. Patients staged American Joint Committee on (AJCC) modified Brigham Women's Hospital (BWH) criteria compared...