A5013266791- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
- Advanced Biosensing Techniques and Applications
- Multiple Myeloma Research and Treatments
- Chemokine receptors and signaling
- Advanced biosensing and bioanalysis techniques
- Medical Imaging Techniques and Applications
- Glycosylation and Glycoproteins Research
- Antibiotics Pharmacokinetics and Efficacy
- Lung Cancer Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Extracellular vesicles in disease
- Selenium in Biological Systems
- Geology and Paleoclimatology Research
- Food Allergy and Anaphylaxis Research
- Phase Equilibria and Thermodynamics
- Skin Protection and Aging
- Gene expression and cancer classification
- Cancer Immunotherapy and Biomarkers
- Radiation Detection and Scintillator Technologies
- Respiratory viral infections research
- Antioxidant Activity and Oxidative Stress
Teva Pharmaceuticals (Czechia)
2025
Johns Hopkins Medicine
2024
Johns Hopkins University
2000-2024
Teva Pharmaceuticals (United States)
2013-2024
Teva Pharmaceuticals (Israel)
2024
University of Chicago
2019-2023
University of Baltimore
2023
US Biologic (United States)
2021
École Polytechnique Fédérale de Lausanne
2015-2021
Bioengineering (Switzerland)
2019-2021
The microbiome modulates host immunity and aids the maintenance of tolerance in gut, where microbial food-derived antigens are abundant. Yet modern dietary factors excessive use antibiotics have contributed to rising incidence food allergies, inflammatory bowel disease other non-communicable chronic diseases associated with depletion beneficial taxa, including butyrate-producing Clostridia. Here we show that intragastrically delivered neutral negatively charged polymeric micelles releasing...
Abstract Dendritic cell (DC)-derived exosomes (Dexo) contain the machinery necessary to activate potent antigen-specific immune responses. As promising cell-free immunogens, Dexo have been tested in previous clinical trials for cancer vaccine immunotherapy, yet resulted limited therapeutic benefit. Here, we explore a novel formulation composed of purified from DCs loaded with antigens and matured either TLR-3 ligand poly(I:C), TLR-4 LPS or TLR-9 CpG-B. When poly(I:C) was used produce...
The clinical efficacy of migraine therapeutic agents directed towards the calcitonin-gene related peptide (CGRP) pathway has confirmed key role this axis in pathogenesis. Three antibodies against CGRP - fremanezumab, galcanezumab and eptinezumab one antibody receptor, erenumab, are clinically approved therapeutics for prevention migraine. In addition, two small molecule receptor antagonists, ubrogepant rimegepant, acute treatment. Targeting either ligand or is efficacious treatment; however,...
CXCR3 is a chemokine receptor for three ligands: CXCL9, CXCL10, and CXCL11. Accumulating evidence, including data presented here, suggests that the interaction between CXCL9/CXCL10 not only attracts CXCR3+ T cells but also promotes induction of IFNγ- high effector/cytotoxic CD4+ CD8+ cells, establishing CXCL9/10-CXCR3-IFNγ self-amplifying cycle efficient cancer cell killing. One homeostatic mechanisms may limit this cleavage two N-terminal amino acids these chemokines by Dipeptidyl Peptidase...
Abstract— Reactive oxygen species are considered to play an important role in cutaneous pathology. Enzymic and non‐enzymic antioxidants can prevent oxidative damage but may be overcome by strong pro‐oxidative stimuli. The acute effect of a single exposure near ultraviolet (UVA)/visible radiation (> 320 nm) on various skin was examined hairless mice immediately after irradiation. Impairment catalase glutathione reductase activity observed. Superoxide dismu‐tase peroxidase were not...
α-Tocopherol (vitamin E) is a lipophilic chain-breaking antioxidant which inhibits lipid peroxidation in isolated mitochondrial membranes and protects from oxidative damage. The primary oxidation product of vitamin E the tocopheroxyl radical. Reduction radical can occur by reactions with water-soluble anti-oxidants such as ascorbate or glutathione, resulting recycling E. Physiological concentrations are too low to allow detection ESR. After dietary supplementation E, 10-20-fold increase rat...
Diagnosis of lung cancer at advanced stages can result in missed treatment opportunities, worse outcomes, and higher health care costs. This study evaluated the wait time to diagnose non-small-cell (NSCLC) cost diagnosis based on stage diagnosis.Adult patients diagnosed with NSCLC between January 2007 September 2011 were identified from a proprietary oncology registry linked insurance claims large US company. Continuous enrollment plan was required for least 12 months prediagnosis (baseline)...
Interferon-α (IFNα) has been prescribed to effectively treat multiple myeloma (MM) and other malignancies for decades. Its use waned in recent years, however, due significant toxicity a narrow therapeutic index (TI). We sought improve IFNα's TI by, first, attaching it an anti-CD38 antibody, thereby directly targeting MM cells, and, second, by introducing attenuating mutation into the IFNα portion of fusion protein rendering relatively inactive on normal, CD38 negative cells. This...
The blood-brain barrier (BBB) largely excludes antibodies from entering the central nervous system, thus limiting potential of therapeutic to treat conditions such as neurodegenerative diseases and neuro-psychiatric disorders. Here, we demonstrate that transport human across BBB in mice can be enhanced by modulating their interactions with neonatal Fc receptor (FcRn). When M252Y/S254T/T246E substitutions are introduced on antibody domain, immunohistochemical assays reveal widespread...
Background Several techniques are currently available to improve the diagnostic yield of routine flexible bronchoscopy. In present study, we have evaluated contribution 2 methods used in our community practice: electromagnetic navigation (EMN, superDimension Ltd, Herzliya, Israel) and rapid on-site cytologic evaluation obtained tissue samples. The main purpose study was determine percentage patients that had a malignant diagnosis or plausible nonmalignant on day procedure. Materials Methods...
We describe the design and operation of a high-throughput facility for synthesizing thousands inorganic crystalline samples per year evaluating them as potential scintillation detector materials. This includes robotic dispenser, arrays automated furnaces, dual-beam X-ray generator diffractometry luminescence spectroscopy, pulsed time response measurements, computer-controlled sample changers, an optical spectrometer, network-accessible database management system that captures all synthesis...