A5015026400- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pregnancy and preeclampsia studies
- Sodium Intake and Health
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Cardiac Arrest and Resuscitation
- Nutritional Studies and Diet
- Birth, Development, and Health
- Cardiac Ischemia and Reperfusion
- NF-κB Signaling Pathways
- Blood Pressure and Hypertension Studies
- Systemic Sclerosis and Related Diseases
- S100 Proteins and Annexins
- Bone Metabolism and Diseases
- Alcohol Consumption and Health Effects
- Hormonal Regulation and Hypertension
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Fungal Infections and Studies
- Calpain Protease Function and Regulation
- Pneumocystis jirovecii pneumonia detection and treatment
- Connective Tissue Growth Factor Research
Emory University
2005-2024
De Montfort University
2021
Cardiovascular Institute Hospital
2015
Emory Healthcare
2015
Emory Clinic
2015
University School
2014
University of Illinois Chicago
2008
Fundación Santa Fe de Bogotá
2006
Centre hospitalier de Rouffach
2006
Duke University
2006
We previously found that angiotensin II–induced hypertension increases vascular extracellular superoxide dismutase (ecSOD), and proposed this is a compensatory mechanism blunts the hypertensive response preserves endothelium-dependent vasodilatation. To test hypothesis, we studied ecSOD-deficient mice. ecSOD −/− C57Blk/6 mice had similar blood pressure at baseline; however, caused by II was greater in compared with wild-type (168 versus 147 mm Hg, respectively; P <0.01). In keeping this,...
Recent work has made it clear that oxidant systems interact. To investigate potential cross talk between NADPH oxidase (Nox) 1 upregulation in vascular smooth muscle and endothelial function, transgenic mice overexpressing Nox1 cells (Tg(SMCnox1)) were subjected to angiotensin II (ANG II)-induced hypertension. As expected, NADPH-dependent superoxide generation was increased aortas from Nox1-overexpressing mice. Infusion of ANG (0.7 mg x kg(-1) day(-1)) for 2 wk potentiated hydrogen peroxide...
Vascular diseases are a major complication of diabetes mellitus (DM), although their etiology is poorly understood. NADPH oxidase-derived reactive oxygen species (ROS) production and inflammation potential mediators DM-associated vascular diseases. Using db/db mice as Type 2 model, we examined the relationship between ROS inflammation. When compared with control m+/+ mice, aortas from 4- 12-wk-old had higher oxidase activity increased superoxide levels, leading to oxidase-dependent impaired...
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member the tumor factor superfamily. TWEAK acts on responsive cells via binding to small cell-surface receptor named fibroblast growth factor-inducible-14 (Fn14). can stimulate numerous cellular responses including cell proliferation, migration, and proinflammatory molecule production. The present study investigated whether plays role in regulation permeability neurovascular unit (NVU). We found that intracerebral injection...
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member the tumor factor superfamily. TWEAK acts via binding to cell surface receptor named Fn14. To study role this cytokine in regulation permeability neurovascular unit (NVU) during cerebral ischemia, activity was inhibited wild-type mice with soluble Fn14-Fc decoy administered either immediately or 1 h after middle artery occlusion (MCAO). Administration resulted faster recovery motor function and 66.4%+/-10% decrease Evans...
Among Latin American countries, Colombia is considered a low-risk area for multiple sclerosis (MS) and no studies on MS prevalence have been conducted in any of the country’s large urban settings. To fill this gap assess Bogotá as December 31, 2002, study reviewed clinical records patients diagnosed with most hospitals. This review produced sample 296 an diagnosis whose reliability was verified by neurologist expertise MS. The total rate identified 2002 4.41/100,000 inhabitants (95% CI...
The extracellular superoxide dismutase (SOD3), a secretory copper-containing enzyme, regulates angiotensin II (Ang II)-induced hypertension by modulating levels of anion. present study was designed to determine the role copper transporter Menkes ATPase (MNK) in Ang II-induced SOD3 activity and vivo. Here we show that chronic infusion enhanced systolic blood pressure vascular anion production MNK mutant (MNK(mut)) mice as compared with those wild-type mice, which are associated impaired...
In HIV-infected patients, central nervous system (CNS) aspergillosis is rare. Historically, the outcome of such infections has been almost invariably fatal. We report a case involving an AIDS patient with Aspergillus fumigatus brain abscess who survived for longer than 10 months after surgical drainage and therapy voriconazole.
Superoxide production in the renal medulla has been suggested to play a major role modulating sodium and water handling blood pressure control. To further study this, we created mice with loxP sites flanking extracellular superoxide dismutase (SOD3) coding region other NADPH oxidase subunit p22 phox . We also transgenic Cre driven by Tamm Horsfall promoter (tg creth mice). SOD3 were then selectively deleted medullar thick ascending limb (mTAL) crossing phloxed tg mice. While baseline...