A5063754448- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Genetic Associations and Epidemiology
- Blood Pressure and Hypertension Studies
- Nutritional Studies and Diet
- Advanced Neuroimaging Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Folate and B Vitamins Research
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Sleep and Wakefulness Research
- Cardiovascular Health and Risk Factors
- Sleep and related disorders
- Epigenetics and DNA Methylation
- Cardiovascular Disease and Adiposity
- Health, Environment, Cognitive Aging
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and genetic disorders
- Nutrition and Health in Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced MRI Techniques and Applications
- Genetics and Neurodevelopmental Disorders
Boston University
2016-2025
Framingham Heart Study
2016-2025
National Heart Lung and Blood Institute
2014-2025
The University of Texas Health Science Center at San Antonio
2018-2024
University of Haifa
2024
Monash University
2022-2024
Brigham and Women's Hospital
2015-2023
Institute for Neurodegenerative Disorders
2018-2023
Harbor–UCLA Medical Center
2023
Douglas Mental Health University Institute
2023
In cross-sectional studies, elevated plasma homocysteine levels have been associated with poor cognition and dementia. Studies of newly diagnosed dementia are required in order to establish whether the precede onset or result from dementia-related nutritional vitamin deficiencies.
Background— Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity mortality, but lifetime risk for AF has not been estimated. Methods Results— We included all participants in Framingham Heart Study who were free at index ages 40 years older. estimated risks (including atrial flutter) to age 95 years, with death as competing event. followed 3999 men 4726 women from 1968 1999 (176 166 person-years); 936 had development 2621 died without prior...
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified genetic sharing 25 disorders from genome-wide association studies 265,218 patients 784,643 control participants assessed relationship to 17 phenotypes 1,191,588 individuals. Psychiatric common variant risk, whereas neurological appear more distinct one another psychiatric disorders. also identified significant between a number...
Background— Congestive heart failure (CHF) is an increasing public health problem. Methods and Results— Among Framingham Heart Study subjects who were free of CHF at baseline, we determined the lifetime risk for developing overt selected index ages. We followed 3757 men 4472 women from 1971 to 1996 124 262 person-years; 583 developed 2002 died without prior CHF. At age 40 years, was 21.0% (95% CI 18.7% 23.2%) 20.3% 18.2% 22.5%) women. Remaining did not change with advancing because rapidly...
Abstract Characterization of the genetic landscape Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for better understanding associated pathophysiological processes. We performed two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases 677,663 controls. found 75 risk loci, which 42 were new at time analysis. Pathway enrichment analyses confirmed involvement amyloid/tau pathways highlighted microglia implication. Gene...
ContextThe long-term risk for developing hypertension is best described by the lifetime statistic. The and trends in this over time are unknown.ObjectivesTo estimate residual older US adults to evaluate temporal risk.Design, Setting, ParticipantsCommunity-based prospective cohort study of 1298 participants from Framingham Heart Study who were aged 55 65 years free at baseline (1976-1998).Main Outcome MeasuresResidual (lifetime cumulative incidence not adjusted competing causes mortality)...
We compared the efficacy of intravenous gamma globulin plus aspirin with that alone in reducing frequency coronary-artery abnormalities children acute Kawasaki syndrome a multicenter, randomized trial. Children randomly assigned to group received globulin, 400 mg per kilogram body weight day, for four consecutive days; both treatment groups aspirin, 100 through 14th day illness, then 3 5 day. Two-dimensional echocardiograms were interpreted blindly and independently by two or more readers....
Background and Purpose Stroke occurring with atrial fibrillation (AF) is more likely to be fatal or severe than non-AF stroke based on clinical series, but data from prospective epidemiological studies are sparse inconsistent. Methods Over 40-year follow-up of the original 5070 Framingham cohort, 501 initial ischemic strokes, including 103 AF, were analyzed. severity was rated as none, mild, moderate, severe, fatal. Since 1981, functional status indicated by Barthel index has been evaluated...
Lifetime risk for atherosclerotic cardiovascular disease (CVD) has not previously been estimated, and the effect of factor burden on lifetime is unknown.We included all Framingham Heart Study participants who were free CVD (myocardial infarction, coronary insufficiency, angina, stroke, claudication) at 50 years age. risks to 95 age estimated men women, with death as a competing event. We followed up 3564 4362 women 111,777 person-years; 1757 had events 1641 died CVD. At age, 51.7% (95% CI,...
Treatment of acute Kawasaki syndrome with a four-day course intravenous gamma globulin, together aspirin, has been demonstrated to be safe and effective in preventing coronary-artery lesions reducing systemic inflammation. We hypothesized that therapy single, very high dose globulin would at least as the standard regimen.
The prevalence of dementia is expected to soar as the average life expectancy increases, but recent estimates suggest that age-specific incidence declining in high-income countries. Temporal trends are best derived through continuous monitoring a population over long period with use consistent diagnostic criteria. We describe temporal three decades among participants Framingham Heart Study.
Our aim was to test the association of vascular risk factor exposure in midlife with progression MRI markers brain aging and measures cognitive decline.A total 1,352 participants without dementia from prospective Framingham Offspring Cohort Study were examined. Multivariable linear logistic regressions implemented study longitudinal change white matter hyperintensity volume (WMHV), (TBV), temporal horn volume, logical memory delayed recall, visual reproductions delayed-recall (VR-d),...
To relate performance on tests of cognitive ability to the subsequent development probable Alzheimer disease (pAD) and identify pattern earliest changes in functioning associated with a diagnosis pAD.From May 1975 November 1979, screening neuropsychological battery was administered Framingham Study participants. They were followed up prospectively for 22 years examined at least every 2 pAD.A community-based center epidemiological research.Subjects 1076 participants aged 65 94 who free...
The lifetime risk (LTR) of stroke has not been reported for the United States population; such data would assist public education and health planning.Framingham Original cohort participants (n=4897) who were stroke- dementia-free at 55 years age followed biennially up to 51 (115 146 person years). We estimated sex-specific 10-, 20-, 30-year risks LTR developing a by baseline blood pressure (BP) compared it with Alzheimer disease (AD).A total 875 (522 women) developed first-ever stroke; 749...
Background: Docosahexaenoic acid (DHA) is an abundant fatty in the brain.In diet, DHA found mostly fish.The content of has been shown to be decreased brain and plasma patients with dementia.Objective: To determine whether phosphatidylcholine (PC) associated risk developing dementia.Design, Setting, Participants: A prospective follow-up study 899 men women who were free dementia at baseline, had a median age 76.0 years, followed up for mean 9.1 years development all-cause Alzheimer...
Stroke is emerging as a major public health problem for women, it men. Controversy persists regarding gender differences in stroke incidence, severity, and poststroke disability.Participants the Framingham Original (n=5119; 2829 women) Offspring (n=4957, 2565 cohorts who were 45 years stroke-free followed to first incident stroke. Gender-specific outcome measures adjusted Risk Profile components.We observed 1136 strokes (638 over 56 of follow-up. Women significantly (P<0.001) older (75.1...
Choline is required to make essential membrane phospholipids. It a precursor for the biosynthesis of neurotransmitter acetylcholine and also an important source labile methyl groups. Mammals fed choline-deficient diet develop liver dysfunction; however, choline not considered nutrient in humans. Healthy male volunteers were hospitalised semisynthetic devoid supplemented with 500 mg/day 1 wk. Subjects randomly divided into two groups, one that continued receive (control), other received no...