Víctor Andrade
A5024747816- Alzheimer's disease research and treatments
- Genetic Associations and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Nutrition, Genetics, and Disease
- Dementia and Cognitive Impairment Research
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- Fatty Acid Research and Health
- SARS-CoV-2 and COVID-19 Research
- Cancer-related gene regulation
- Folate and B Vitamins Research
- Liver Disease Diagnosis and Treatment
- Health, Environment, Cognitive Aging
- Atherosclerosis and Cardiovascular Diseases
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Wnt/β-catenin signaling in development and cancer
- Humic Substances and Bio-Organic Studies
- Protease and Inhibitor Mechanisms
- Cardiovascular Disease and Adiposity
- Congenital heart defects research
- COVID-19 Clinical Research Studies
University of Cologne
2019-2023
University Hospital Bonn
2020-2023
University Hospital Cologne
2022-2023
Molecular Biology Consortium
2023
University of Chile
2017-2023
University of Stavanger
2021
University of Bonn
2019
Universidad Andrés Bello
2016-2018
Millennium Institute for Integrative Biology
2018
Abstract Characterization of the genetic landscape Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for better understanding associated pathophysiological processes. We performed two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases 677,663 controls. found 75 risk loci, which 42 were new at time analysis. Pathway enrichment analyses confirmed involvement amyloid/tau pathways highlighted microglia implication. Gene...
Genetic discoveries of Alzheimer's disease are the drivers our understanding, and together with polygenetic risk stratification can contribute towards planning feasible efficient preventive curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets by-proxy results (discovery n = 409,435 validation size 58,190). Here, we add six variants associated (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 two exonic in SHARPIN gene). Assessment...
ABSTRACT Alzheimer’s disease (AD) is a severe and incurable neurodegenerative disease, the failure to find effective treatments suggests that underlying pathology remains poorly understood. Due its strong heritability, deciphering genetic landscape of AD related dementia (ADD) unique opportunity advance our knowledge. We completed meta-analysis genome-wide association studies (39,106 clinically AD-diagnosed cases, 46,828 proxy-ADD cases 401,577 controls) with most promising signals...
Abstract Alzheimer’s disease has a long asymptomatic phase that offers substantial time window for intervention. Using this of opportunity will require early diagnostic and prognostic biomarkers to detect pathology at predementia stages, thus allowing identification patients who most probably progress dementia the type benefit from specific disease-modifying therapies. Consequently, we searched CSF proteins associated with progression along clinical staging. We measured levels 184 in samples...
Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the degree subjects at moment DNA sampling. Therefore, phenotype associations AD can be severely age-confounded in context genome-wide association studies. Here, we applied Mendelian randomisation to construct an age-independent polygenic risk score (mloy-PRS) using 114 autosomal...
Alzheimer's disease (AD) is a neurodegenerative characterized by progressive cognitive impairment of patients, affecting around 12% people older than 65 years old. WHO estimated that over 48.6 million all the world suffer this disease. On basis cumulative results on our research, we have postulated neuroimmunomodulation hypothesis appears to provide reasonable explanation both preclinical and clinical observations. In context, long-term activation innate immune system triggers an anomalous...
Abstract Synaptic abnormalities have been described in individuals with autism spectrum disorders (ASD). The cell-adhesion molecule Neuroligin-3 (Nlgn3) has an essential role the function and maturation of synapses NLGN3 ASD-associated mutations disrupt hippocampal cortical function. Here we show that Wnt/β-catenin signaling increases Nlgn3 mRNA protein levels HT22 mouse cells primary cultures rat neurons. We characterized activity promoter constructs containing conserved putative T-cell...
ABSTRACT BACKGROUND Disentangling the genetic constellation underlying Alzheimer’s disease (AD) is important. Doing so allows us to identify biological pathways AD, point towards novel drug targets and use variants for individualised risk predictions in modifying or prevention trials. In present work we report on largest genome-wide association study (GWAS) AD date show combined utility of proven loci precision medicine using polygenic scores (PRS). METHODS Three sets summary statistics were...
Wnt/ β -catenin signaling modulates brain development and function its deregulation underlies pathological changes occurring in neurodegenerative neurodevelopmental disorders. Since one of the main effects is modulation target genes, present work we examined global transcriptional induced by short-term Wnt3a treatment (4 h) primary cultures rat hippocampal neurons. RNAseq experiments allowed identification 170 differentially expressed including known genes such as Notum, Axin2, Lef1, well...
Background:Alzheimer's disease (AD) is a multifactorial disease, that involves neuroinflammatory processes in which microglial cells respond to "damage signals". The latter includes oligomeric tau, iron, oxidative free radicals, and other molecules promotes neuroinflammation the brain, prom oting neuronal death cognitive impairment. Since AD first cause of dementia elderly, its pharmacotherapy has limited efficacy, novel treatments are critical improve quality life patients. Multitarget...
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder without cure, despite the enormous number of investigations and therapeutic approaches. AD consequence microglial responses to "damage signals", such as aggregated tau oligomers, which trigger neuro-inflammatory reaction, promoting misfolding cytoskeleton structure. Since most prevalent cause dementia in elderly (>60 years old), new treatments are essential improve well-being affected subjects. The pharmaceutical...
According to the WHO, antimicrobial resistance is among top 10 threats global health. Due increased rates, an increase in mortality and morbidity of patients has been observed, with projections more than million deaths associated infections caused by antibacterial resistant microorganisms. Our research group developed a new family pyrimido-isoquinolin-quinones showing activities against multidrug-resistant Staphylococcus aureus. We have 3D-QSAR CoMFA CoMSIA studies (r2 = 0.938; 0.895), from...
Evidence-based Nutraceutical Compounds (EBNC), containing bioactive principles of demonstrated efficacy and health security are opening solutions for a modern preventive medicine, as potential many chronic diseases the human beings. EBNC contain components diet that can be used prevention or treatment disease. They obtained through rigorous processes extraction from natural resources Good Manufacturing Practices (GMP) regulations, exhibit sound preclinical studies published in high impact...
Abstract Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis Alzheimer’s disease (AD) more directly than clinical diagnosis. Initiated by European Alzheimer & Dementia Biobank (EADB), largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total 13,116 individuals (discovery n = 8,074; replication 5,042 individuals). Besides APOE locus, novel associations...
ABSTRACT Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event occurring exclusively in men and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the degree subjects at moment DNA sampling. Therefore, phenotype associations AD can be severely age-confounded context genome-wide association studies. Here, we applied Mendelian randomization to construct an age-independent polygenic risk score...
Abstract Background The most relevant risk factor in Alzheimer’s disease (AD) is age. Aging a complex process involving several biological changes which lead to chronic cellular stress and sterile tissue inflammation. During aging cells become senescent seen as morphological secretion of immune signaling mediators associated with systemic low‐grade Interestingly, during neurodegenerative processes such AD, microglia, astrocytes, vascular unit senescent. To explore the potential connection...
Abstract Background Previous research reported the association between circulating Omega‐3 polyunsaturated fatty acids (PUFA) in blood and risk of dementia Alzheimer’s disease (AD). However, a large intervention study supplementing that this supplementation has only marginal effect on improvement cognitive performance after supplementation. Since PUFA metabolism shared processing enzymes, we explored whether relationship two main families PUFA, i.e., Omega‐6, might associate with...