A5049857345- Alzheimer's disease research and treatments
- Wnt/β-catenin signaling in development and cancer
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Genetic Associations and Epidemiology
- Dementia and Cognitive Impairment Research
- Computational Drug Discovery Methods
- Prion Diseases and Protein Misfolding
- Bioinformatics and Genomic Networks
- Nuclear Receptors and Signaling
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Cancer-related gene regulation
- Neurological diseases and metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Genomic variations and chromosomal abnormalities
- Health, Environment, Cognitive Aging
- Marine Sponges and Natural Products
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Insect Resistance and Genetics
- Viral Infectious Diseases and Gene Expression in Insects
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
Fundacion Centro De Investigacion De Enfermedades Neurologicas
2015-2024
Unidad Funcional de Investigación de Enfermedades Crónicas
2020-2024
Instituto de Salud Carlos III
2017-2024
Biomedical Research Networking Center on Neurodegenerative Diseases
2015-2024
Hospital La Paz Institute for Health Research
2019-2023
Indian Institute of Technology Kharagpur
2023
Molecular Biology Consortium
2023
New York City College of Technology
2023
City University of New York
2023
Charlottesville Medical Research
2023
Abstract: Paired helical filaments isolated from the brains of patients with Alzheimer's disease are composed a major protein component, microtubule‐associated termed τ, together other nonprotein components, including heparan, glycosaminoglycan, more extensively sulfated form which is heparin. As some these components may modulate assembly τ into filamentous structures, we have analyzed ability whole or its fragments to self‐assemble in presence Different fragments, all them containing...
This pilot, double-blind, placebo-controlled, randomized, escalating dose trial explored the safety and efficacy of tideglusib, an inhibitor glycogen synthase kinase-3, in Alzheimer's disease (AD) patients. Thirty mild-moderate AD patients on cholinesterase treatment were administered doses (400, 600, 800, 1,000 mg) tideglusib or placebo (ratio 2 : 1) for 4, 6, 6 weeks, respectively. The primary objective was to evaluate tolerability with strict criteria drug escalation withdrawal....
Recent experimental and clinical retrospective studies support the view that reduction of brain cholesterol protects against Alzheimer's disease (AD). However, genetic pharmacological evidence indicates low leads to neurodegeneration. This apparent contradiction prompted us analyze role neuronal in amyloid peptide generation systems closely resemble physiological pathological situations. We show that, hippocampus control human transgenic mice, only a small pool endogenous APP its...
ONE approach to understanding the function of presenilin 1 (PS1), is discover those proteins with which it interacts. Evidence for a in developmental patterning came from C. elegans, PS homologue was identified by screening suppressors mutation Notch/lin-12, gene specifies cell fate. However, this genetic experiment cannot determine directly interact PS1. Therefore, we utilized two hybrid system and confirmatory co-immunoprecipitations identify novel catenin, termed β-catenin, interacts PS1...
Neuritogenesis, the first step of neuronal differentiation, takes place as nascent neurites bud from immediate postmitotic soma. Little is known about mechanisms underlying dramatic morphological changes that characterize this event. Here, we show RhoA activity plays a decisive role during neuritogenesis cultured hippocampal neurons by recruiting and activating its specific kinase ROCK, which, in turn, complexes with profilin IIa. We establish previously uncharacterized brain-specific...
New dual binding site acetylcholinesterase (AChE) inhibitors have been designed and synthesized as new potent drugs that may simultaneously alleviate cognitive deficits behave disease-modifying agents by inhibiting the beta-amyloid (A beta) peptide aggregation through to both catalytic peripheral sites of enzyme. Particularly, compounds 5 6 emerged most heterodimers reported so far, displaying IC50 values for AChE inhibition 20 60 pM, respectively. More importantly, these inhibit...
Glycogen synthase kinase‐3 (GSK‐3) unique position in modulating the function of a diverse series proteins combination with its association wide variety human disorders has attracted significant attention to protein both as therapeutic target and means understand molecular basis these disorders. GSK‐3 is ubiquitously expressed and, unusually, constitutively active resting, unstimulated cells. In mammals, α β are each widely at RNA levels although some tissues show preferential two proteins....
Background: Alzheimer's disease (AD) is a silent disorder that needs the earliest possible intervention in order to reduce its high economic and social impact. It has been recently suggested subjective cognitive decline (SCD) appears at preclinical stages many years before onset of AD. The refore, SCD could become an ideal target for early therapeutic intervention. Objective: goal this study was evaluate clinical significance on conversion from cognitively healthy stage mild impairment (MCI)...
Cognitive abilities, particularly memory, normally decline with age. However, some individuals, often designated as superagers, can reach late life the memory function of individuals 30 years younger. We aimed to characterise brain structure superagers and identify demographic, lifestyle, clinical factors associated this phenotype.
The classical adherens junction that holds epithelial cells together consists of a protein complex in which members the cadherin family linked to various catenins are principal components. delta-catenin is mammalian brain Armadillo repeat superfamily with sequence similarity p120(ctn). We found can be immunoprecipitated as other components junction, including and beta-catenin, from transfected brain. interaction involves direct contact within highly conserved juxtamembrane region COOH...
Manzamine A and related derivatives isolated from a common Indonesian sponge, Acanthostrongylophora, have been identified as new class of GSK-3β inhibitors. The semisynthesis analogues the first structure–activity relationship studies with are also reported. Moreover, manzamine proved to be effective in decreasing tau hyperphosphorylation human neuroblastoma cell lines, demonstration its ability enter cells interfere pathology. Inhibition against selected panel five different kinases GSK-3β,...