A5062299794- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Neuropeptides and Animal Physiology
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Alzheimer's disease research and treatments
- Menopause: Health Impacts and Treatments
- Computational Drug Discovery Methods
- Hormonal Regulation and Hypertension
- Adenosine and Purinergic Signaling
- Cholinesterase and Neurodegenerative Diseases
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Estrogen and related hormone effects
- Stress Responses and Cortisol
- Diabetes and associated disorders
- Hormonal and reproductive studies
- Inflammation biomarkers and pathways
- Neural dynamics and brain function
- Marine Sponges and Natural Products
- Nicotinic Acetylcholine Receptors Study
- Tryptophan and brain disorders
- Adrenal Hormones and Disorders
Universidade de Santiago de Compostela
2013-2024
Biomedical Research Networking Center on Neurodegenerative Diseases
2011-2024
Center for Research in Molecular Medicine and Chronic Diseases
2019-2024
Instituto de Salud Carlos III
2024
Instituto de Investigación Sanitaria de Santiago
2023
Universidad de Navarra
2010
Morpho (United States)
2010
Neuron BioPharma (Spain)
2006-2008
Universitat de Barcelona
2005
University of Bologna
2005
New dual binding site acetylcholinesterase (AChE) inhibitors have been designed and synthesized as new potent drugs that may simultaneously alleviate cognitive deficits behave disease-modifying agents by inhibiting the beta-amyloid (A beta) peptide aggregation through to both catalytic peripheral sites of enzyme. Particularly, compounds 5 6 emerged most heterodimers reported so far, displaying IC50 values for AChE inhibition 20 60 pM, respectively. More importantly, these inhibit...
Abstract The renin–angiotensin system (RAS) was initially considered as a circulating humoral controlling blood pressure, being kidney the key control organ. In addition to ‘classical’ RAS, second level in local or tissular has been identified variety of tissues, which RAS play role degenerative and aging-related diseases. brain plays major function neurodegeneration. It is normally assumed that effects are mediated by cell-surface-specific G-protein-coupled angiotensin type 1 2 receptors...
The renin-angiotensin system (RAS) plays a major role in COVID-19. Severity of several inflammation-related diseases has been associated with autoantibodies against RAS, particularly agonistic for angiotensin type-1 receptors (AA-AT1) and ACE2 (AA-ACE2). Disease severity COVID-19 patients was defined as mild, moderate or severe following the WHO Clinical Progression Scale determined at medical discharge. Serum AA-AT1 AA-ACE2 were measured (n = 119) non-infected controls 23) using specific...
Abstract The key link between renin–angiotensin system (RAS) and COVID-19 is ACE2 (angiotensin-converting enzyme 2), which acts as a double-edged sword, because increases the tissue anti-inflammatory response but it also entry receptor for virus. There an important controversy on several drugs that regulate RAS activity possibly ACE2, are widely used, particularly by patients most vulnerable to severe COVID-19. In lung of healthy rats, we observed candesartan (an angiotensin type-1, AT1,...
We have previously obtained in rodents a considerable amount of data suggesting major role for the brain renin-angiotensin system (RAS) dopaminergic neuron degeneration and potentially Parkinson's disease. However, presence local RAS has not been demonstrated monkey or human substantia nigra compacta (SNc). The present study demonstrates components neurons, astrocytes microglia both SNc. Angiotensin type 1 2 renin-prorenin receptors were located at surface neurons glial cells, as expected...
Abstract The role of autoimmunity in neurodegeneration has been increasingly suggested. renin-angiotensin system (RAS) autoantibodies play a major several peripheral inflammatory processes. Dysregulation brain RAS involved neuroinflammation and neurodegeneration. We aimed to know whether angiotensin type-1 receptor (AT1) (AT1 agonists) angiotensin-converting enzyme 2 (ACE2) (ACE2 antagonists) may be Parkinson’s disease (PD) progression constitute new therapeutical target. Both AT1 ACE2 serum...
The basal ganglia have a local renin-angiotensin system and it has been shown that the loss of dopaminergic neurons induced by neurotoxins is amplified angiotensin II (AII) via type 1 receptors (AT1) nicotinamide adenine dinucleotide phosphate (NADPH) complex activation. Recent studies revealed high degree counter-regulatory interactions between dopamine AII in non-neural cells such as renal proximal tubule cells. However, not known if this occurs ganglia. In striatum nigra, depletion with...
There is a lack of consensus about the effects type menopause (surgical or natural) and oestrogen replacement therapy on Parkinson's disease. The timing female's age may explain observed differences in such effects. However, mechanisms involved are poorly understood. renin-angiotensin system mediates beneficial several tissues, we have previously shown that dopaminergic cell loss enhanced by angiotensin via 1 receptors, which activated ageing. In rats, compared 6-hydroxydopamine-induced...
Abstract The ‘classical’ renin–angiotensin system (RAS) is a circulating that controls blood pressure. Local/paracrine RAS, identified in variety of tissues, including the brain, involved different functions and diseases, RAS blockers are commonly used clinical practice. A third type (intracellular/intracrine RAS) has been observed some types cells, neurons. However, its role still unknown. present results indicate brain cells intracellular counteracts superoxide/H 2 O oxidative stress...
Lipid nanoparticles (LNPs) currently dominate the RNA delivery landscape; however their limited diffusivity hampers targeted tissue dissemination, and, hence, capacity for intracellular drug delivery. This is especially relevant tissues such as central nervous system (CNS), where overcoming proactive brain barriers crucial efficacy of genetic therapeutics. research aimed to create ionizable nanoemulsions (iNEs), a new generation systems with enhanced diffusivity. The developed iNEs...
ACE2 plays a pivotal role in the balance between pro-oxidative pro-inflammatory and anti-oxidative anti-inflammatory arms of renin-angiotensin system. Furthermore, is entry receptor for SARS-CoV-2. Clarification ACE2-related mechanisms crucial understanding COVID-19 other oxidative stress inflammation-related processes. In rat monkey brain, we discovered that intracellular its products Ang 1–7 alamandine are highly concentrated mitochondria bind to new mitochondrial Mas-related MrgE (MrgE)...
Angiotensin II acts via angiotensin type 1 receptors and is a major inducer of inflammation oxidative stress. Local renin-angiotensin systems play role in the development age-related disorders several tissues. These processes are delayed, but not totally abolished, by blockade signaling. A specific receptor for renin its precursor prorenin has recently been identified. We previously showed that neurotoxin-induced dopaminergic (DA) cell loss decreased inhibition receptors, location functional...