A5044723172- Parkinson's Disease Mechanisms and Treatments
- Restless Legs Syndrome Research
- COVID-19 Clinical Research Studies
- Receptor Mechanisms and Signaling
- SARS-CoV-2 and COVID-19 Research
- Renin-Angiotensin System Studies
- Ginkgo biloba and Cashew Applications
- Dementia and Cognitive Impairment Research
- Colorectal Cancer Treatments and Studies
- Tryptophan and brain disorders
- Long-Term Effects of COVID-19
- Diabetes and associated disorders
- Neurological disorders and treatments
- Neurological diseases and metabolism
- Nuclear Receptors and Signaling
- Hereditary Neurological Disorders
- Genetic Neurodegenerative Diseases
- Treatment of Major Depression
- Brain Metastases and Treatment
- Child Nutrition and Feeding Issues
- Mast cells and histamine
- GDF15 and Related Biomarkers
- COVID-19 Impact on Reproduction
- Cancer, Stress, Anesthesia, and Immune Response
- Intraperitoneal and Appendiceal Malignancies
University of Maryland, Baltimore
2025
Complejo Hospitalario de Ourense
2022-2024
Complexo Hospitalario Universitario A Coruña
2023
University Hospital Complex Of Vigo
2017-2022
Center for Research in Molecular Medicine and Chronic Diseases
2020-2022
Universidade de Santiago de Compostela
2020-2022
The renin-angiotensin system (RAS) plays a major role in COVID-19. Severity of several inflammation-related diseases has been associated with autoantibodies against RAS, particularly agonistic for angiotensin type-1 receptors (AA-AT1) and ACE2 (AA-ACE2). Disease severity COVID-19 patients was defined as mild, moderate or severe following the WHO Clinical Progression Scale determined at medical discharge. Serum AA-AT1 AA-ACE2 were measured (n = 119) non-infected controls 23) using specific...
Abstract The key link between renin–angiotensin system (RAS) and COVID-19 is ACE2 (angiotensin-converting enzyme 2), which acts as a double-edged sword, because increases the tissue anti-inflammatory response but it also entry receptor for virus. There an important controversy on several drugs that regulate RAS activity possibly ACE2, are widely used, particularly by patients most vulnerable to severe COVID-19. In lung of healthy rats, we observed candesartan (an angiotensin type-1, AT1,...
Abstract The role of autoimmunity in neurodegeneration has been increasingly suggested. renin-angiotensin system (RAS) autoantibodies play a major several peripheral inflammatory processes. Dysregulation brain RAS involved neuroinflammation and neurodegeneration. We aimed to know whether angiotensin type-1 receptor (AT1) (AT1 agonists) angiotensin-converting enzyme 2 (ACE2) (ACE2 antagonists) may be Parkinson’s disease (PD) progression constitute new therapeutical target. Both AT1 ACE2 serum...
Abstract The renin-angiotensin system (RAS) was classically considered a circulating hormonal that regulates blood pressure. However, different tissues and organs, including the brain, have local paracrine RAS. Mutual regulation between dopaminergic RAS has been observed in several tissues. Dysregulation of these interactions leads to renal cardiovascular diseases, as well progression neuron degeneration major brain center dopamine/angiotensin interaction such nigrostriatal system. A...
Rho kinase (ROCK) activation is involved in neuroinflammatory processes leading to progression of neurodegenerative diseases such as Parkinson's disease. Furthermore, ROCK plays a major role angiogenesis. Neuroinflammation and angiogenesis are mechanisms developing l-DOPA-induced dyskinesias (LID). However, it not known whether LID inhibitors may be useful against LID.In rats, we performed short- long-term dopaminergic lesions using 6-hydroxydopamine developed model. Effects on the RhoA/ROCK...
Quality of life (QOL) plays an important role in independent living Parkinson's disease (PD) patients, being crucial to know what factors impact QoL throughout the course disease. Here we identified predictors impairment PD patients from a Spanish cohort. recruited 35 centers Spain COPPADIS cohort January 2016, November 2017, were followed up during 2 years. Health-related (HRQoL) and global (GQoL) assessed with 39-item Questionnaire (PDQ-39) EUROHIS-QOL 8-item index (EUROHIS-QOL8),...
Some studies observed a benefit of Parkinson's disease (PD) patients after treatment with safinamide in some non-motor symptoms (NMSs). The aim this study was to analyze the effectiveness on NMS burden PD. SAFINONMOTOR (an open-label patients) is prospective single-arm conducted five centers from Spain. primary efficacy outcome change baseline (V1) end observational period (6 months) (V4) scale (NMSS) total score. Between May/2019 and February/2020 50 were included (age 68.5 ± 9.12 years;...
The metabolic syndrome has been associated to chronic peripheral inflammation and related with neuroinflammation neurodegeneration, including Parkinson's disease. However, the responsible mechanisms are unclear. Previous studies have involved brain renin-angiotensin system in progression of disease angiotensin receptor type 1 (AT1) recently revealed as a major marker dopaminergic vulnerability humans. Dysregulation tissue is key common mechanism for all components syndrome. Circulating AT1...
Background and objective: Pain is a frequent disabling symptom in Parkinson’s disease (PD) patients. Our aim was to analyze the effectiveness of safinamide on pain PD patients from SAFINONMOTOR (an open-label study SAFInamide NON-MOTOR symptoms Parkinson´s patients) study. Material Methods: prospective single-arm conducted five centers Spain. In this analysis, secondary objective study, score KPPS (King´s Disease Scale) at V1 (baseline) V4 (6 months ± 1 month) were compared. Wilcoxon´s rank...
Depression is frequent in Parkinson’s disease (PD) patients, but the evidence for many antidepressant agents to treat it PD insufficient. The aim of present prospective open-label single-arm study (VOPARK, an effectiveness and safety VOrtioxetine PARKinson’s patients with depression) was analyze vortioxetine on depressive symptoms major depression. primary efficacy outcome change from baseline (VB) at end observational period (12 weeks ± 14 days; V12w) 17-item Hamilton Rating Scale (HAM-D17)...
Ataxia and hereditary spastic paraplegia are rare neurodegenerative syndromes. We aimed to determine the prevalence of these disorders in Spain 2019.We conducted a cross-sectional, multicentre, retrospective, descriptive study patients with ataxia between March 2018 December gathered data from total 1933 11 autonomous communities, provided by 47 neurologists or geneticists. Mean (SD) age our sample was 53.64 (20.51) years; 938 were men (48.5%) 995 women (51.5%). The genetic defect...
Several studies showed an association between metabolic syndrome (MetS) and Parkinson's disease (PD). The linking mechanisms remain unclear. MetS promotes low-grade peripheral oxidative stress inflammation dysregulation of the adipose renin-angiotensin system (RAS). Interestingly, brain RAS is involved in progression dopaminergic degeneration PD. Circulating extracellular vesicles (EVs) from fat tissue can cross brain-blood barrier may act as signals. We isolated characterized EVs control...
In a patient who had been diagnosed of located squamous cell lung carcinoma, pneumonectomy, and adjuvant chemotherapy were performed. Brain recurrence subsequent metastatic disease uncontrolled by neurosurgery, holocranial radiotherapy, first-line chemotherapy. August 2015, appearance leptomeningeal carcinomatosis triggered severe clinical deterioration threatened the patient's life. Anti-PD1 immune checkpoint inhibitor Nivolumab was initiated in an attempt to stop tumor growth, achieving...
Abstract The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) subjects (CS) as well relationship between ICDs/CBs motor, nonmotor features dopaminergic treatment PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used validated Questionnaire for Impulsive-Compulsive Disorders Parkinson's Disease-Rating Scale (QUIP-RS) ICD/CB screening....
There is a need for identifying risk factors hospitalization in Parkinson's disease (PD) and also interventions to reduce acute hospital admission.To analyze the frequency, causes, predictors of (AH) PD patients from Spanish cohort.PD recruited 35 centers Spain COPPADIS-2015 (COhort Patients with PArkinson's DIsease Spain, 2015) cohort January 2016 November 2017, were included study. In order identify AH, Kaplan-Meier estimates considered as potential obtained Cox regression performed on...
Mood disorders are frequent in Parkinson's disease (PD) and a favorable effect of safinamide on mood has been observed. We aimed to analyze the effectiveness as secondary objective from SAFINONMOTOR (an open-label study SAFInamide NON-MOTOR symptoms patients with disease) study. is prospective single-arm conducted five centers Spain. Patients PD were required have at baseline Non-Motor Symptoms Scale (NMSS) total score least 40. In this analysis, changes V1 (baseline) V4 (6 months ± 1 month)...
Las ataxias (AT) y paraparesias espásticas hereditarias (PEH) son síndromes neurodegenerativos raros. Nos proponemos conocer la prevalencia de las AT PEH en España 2019. Estudio transversal, multicéntrico, descriptivo retrospectivo los pacientes con PEH, desde marzo 2018 a diciembre 2019 toda España. Se obtuvo información 1.933 procedentes 11 Comunidades Autónomas, 47 neurólogos o genetistas. Edad media: 53,64 años ± 20,51 desviación estándar (DE); 920 varones (50,8%), 889 mujeres (49,2%)....
We previously showed that angiotensin type-1 receptor and ACE2 autoantibodies (AT1-AA, ACE2-AA) are associated with COVID-19 severity. Our aim is to find correlations of these routine biochemical parameters allow an initial classification patients. In cohort 119 patients, serum AT1-AA ACE2-AA concentrations were obtained within 24 h after diagnosis. 50 patients a complete set parameters, clinical data disease outcome information, Random Forest algorithm was used select prognostic indicators,...