A5073935320- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Balance, Gait, and Falls Prevention
- Parkinson's Disease and Spinal Disorders
- Advanced MRI Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Mitochondrial Function and Pathology
- Neurological diseases and metabolism
- Autism Spectrum Disorder Research
- Cerebral Palsy and Movement Disorders
- Voice and Speech Disorders
- Eating Disorders and Behaviors
- Synthesis and Reactivity of Heterocycles
- Behavioral and Psychological Studies
- Dysphagia Assessment and Management
- Neurotransmitter Receptor Influence on Behavior
- LGBTQ Health, Identity, and Policy
- Accounting and Financial Management
University Hospital HM Puerta del Sur
2017-2024
Hospital Clínico San Carlos
2015-2024
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2019-2024
HM Hospitales
2021-2024
Universidad Complutense de Madrid
2023-2024
Centro de Investigación Biomédica en Red
2023
Instituto de Salud Carlos III
2023
Biomedical Research Networking Center on Neurodegenerative Diseases
2019-2023
Universidad San Pablo CEU
2017-2021
Universidad San Pablo
2020
The pathophysiology of levodopa-induced dyskinesias (LID) in Parkinson's disease is not well understood. We have recorded local field potentials (LFP) from macroelectrodes implanted the subthalamic nucleus (STN) 14 patients with following surgical treatment deep brain stimulation. Patients were studied 'Off' medication state and 'On' motor after administration levodopa-carbidopa (po) or apomorphine (sc) that elicited 11 patients. logarithm power spectrum LFP selected frequency bands (4-10,...
The subthalamic nucleus is the preferred neurosurgical target for deep-brain stimulation to treat cardinal motor features of Parkinson's disease. Focused ultrasound an imaging-guided method creating therapeutic lesions in structures, including nucleus.We randomly assigned, a 2:1 ratio, patients with markedly asymmetric disease who had signs not fully controlled by medication or were ineligible surgery undergo focused subthalamotomy on side opposite their main sham procedure. primary efficacy...
Estimates of the spectrum and frequency pathogenic variants in Parkinson's disease (PD) different populations are currently limited biased. Furthermore, although therapeutic modification several genetic targets has reached clinical trial stage, a major obstacle conducting these trials is that PD patients largely unaware their status and, therefore, cannot be recruited. Expanding number investigated PD-related genes including related to disorders with overlapping features large,...
Abstract A voluntary movement is accompanied by a series of changes in neuronal oscillatory activity the subthalamic nucleus (STN). These can be recorded through electrodes implanted for deep brain stimulation to treat Parkinson's disease time interval between surgery and internalization connections batteries. Both baseline movement‐related are different ‘on’ ‘off’ medication motor states. In state low frequency alpha–beta range (8–25 Hz) that dominates spectrum interrupted during movement,...
Unilateral magnetic resonance-guided focused ultrasound subthalamotomy (FUS-STN) has been shown to improve the cardinal motor features of Parkinson disease (PD). Whether this effect is sustained not known. This study aims report long-term outcome patients with PD treated unilateral FUS-STN.We conducted a prospective open-label asymmetrical who underwent FUS-STN. All were evaluated up 36 months after treatment. The primary was difference from baseline FUS-STN in score Movement Disorder...
In Parkinson's disease, striatal dopamine depletion produces profound alterations in the neural activity of cortico-basal ganglia motor loop, leading to dysfunctional output and parkinsonism. A key regulator is balance between excitation inhibition primary cortex, which can be assessed humans with transcranial magnetic stimulation techniques. Despite decades research, functional state cortical disease remains uncertain. Towards resolving this issue, we applied paired-pulse protocols 166...
Background and purpose The objective of this study was to analyze the relationship between motor complications non‐motor symptom (NMS) burden in a population patients with Parkinson’s disease (PD) also subgroup early PD. Methods Patients PD from COPPADIS cohort were included cross‐sectional study. NMS defined according Non‐Motor Symptoms Scale (NMSS) total score. Unified Disease Rating (UPDRS) part IV used establish complication types their severity. ≤5 years symptoms onset as Results Of 690...
Unilateral magnetic resonance imaging (MRI)-guided focused ultrasound subthalamotomy (FUS-STN) improves cardinal motor features among patients with asymmetrical Parkinson disease (PD). The feasibility of bilateral FUS-STN is as yet unexplored.
Abstract Background: Diphasic dyskinesias are a subtype of levodopa‐induced that appear typically at the onset and end levodopa antiparkinsonian action. The pathophysiology diphasic is not well understood. Methods: We analyzed local field potentials recorded from subthalamic nucleus in 7 Parkinson's disease (PD) patients who showed typical during postoperative recordings through deep brain stimulation electrode. evolution different oscillatory activities related to was studied by windowed...
ABSTRACT Objective To define the motor onset and progression of Parkinson's disease (PD) in a prospective cohort early unmedicated patients. Methods We enrolled consecutive recently diagnosed (<18 months) PD patients with unilateral manifestations using age gender‐matched controls. The most affected body region was determined various clinical standard metrics objective quantitative kinematic measurements. Progression Markers Initiative data were used for external validation results....
Motor cortex disinhibition, as measured by impaired short-interval intracortical inhibition (SICI) using transcranial magnetic stimulation (TMS), is a well-established feature of Parkinson's disease (PD). However, its substantial variability among patients remains unexplained, prompting questions about origin, clinical relevance, and connection to heterogeneity. Based on biological links between olfaction motor function, we aimed investigate the possible relationship disinhibition olfactory...
Directional subthalamic stimulation in Parkinson's disease can increase threshold for adverse effects and widen the therapeutic window. However, selection of programming settings is time consuming, requiring a thorough monopolar clinical review. To overcome this, may be guided by intraoperatively recording local field potential beta oscillations (13-35 Hz).1) Evaluate whether power recorded predict clinically most effective directional contacts; 2) assess long-term outcomes between patients...
Multiple sclerosis (MS)-related tremor is frequent and can often be refractory to medical treatment, which makes it a potential source of major disability. Functional neurosurgery approaches such as thalamic deep brain stimulation (DBS) or radiofrequency thalamotomy are proven effective, but the application invasive techniques in MS has so far been limited. Magnetic resonance (MR)-guided focused ultrasound thalamotomy, already approved for treating essential parkinsonian tremor, provides...
Transcranial static magnetic field stimulation (tSMS) is a recent low-cost non-invasive brain technique that decreases cortical excitability in healthy subjects. The objective of the present study was to test ability tSMS modulate patients with Parkinson's disease. We performed randomized double-blind sham-controlled cross-over assess before and immediately after (or sham) applied for 10 min more affected motor cortex Cortical quantified by amplitude evoked potentials (MEPs) elicited...
Deep brain stimulation (DBS) is widely used for treatment of advanced, medication-refractory Parkinson's disease (PD). However, a significant proportion patients may suffer adverse effects; up to 10% will present one or more transient permanent neurobehavioral events.In our case study, 44-year-old woman diagnosed with PD 6 years previously who was suffering from motor fluctuations, dyskinesia, and freezing gait episodes submitted DBS implanted directional electrodes. Intraoperative local...
Abstract BACKGROUND Although deep brain stimulation (DBS) of the dorsolateral subthalamic nucleus (STN) is a well-established surgical treatment for patients with Parkinson disease (PD), there still controversy about relationship between functional segregation STN and clinical outcomes. OBJECTIVE To correlate motor neuropsychological (NPS) outcomes overlap volume activated tissue (VAT) tractography-defined regions within STN. METHODS Retrospective study evaluating 13 PD treated STN-DBS. With...
Impulse-control disorder is a common neuropsychiatric complication in Parkinson's disease (PD) under dopamine replacement therapy. Prior studies tested the balance between enhanced desire towards reward and cognitive control deficits, hypothesized to be biased former impulse disorders. We provide evidence for this hypothesis by measuring behavioral neural patterns behind influence of sexual over response inhibition tools functional restoration using repetitive transcranial stimulation...