A5084530518- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Alzheimer's disease research and treatments
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Ultrasound and Hyperthermia Applications
- Eating Disorders and Behaviors
- Phosphorus compounds and reactions
- Autism Spectrum Disorder Research
- Geriatric Care and Nursing Homes
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Synthesis and Reactivity of Heterocycles
- Sexuality, Behavior, and Technology
- LGBTQ Health, Identity, and Policy
- Neural and Behavioral Psychology Studies
- Palliative Care and End-of-Life Issues
- Ultrasound Imaging and Elastography
- Porphyrin Metabolism and Disorders
- Neurobiology of Language and Bilingualism
- Neurotransmitter Receptor Influence on Behavior
- Intelligent Tutoring Systems and Adaptive Learning
- Neuroscience and Neural Engineering
Universidad Autónoma de Madrid
2022-2024
HM Hospitales
2021-2024
University Hospital HM Puerta del Sur
2019-2024
Instituto Cajal
2021-2024
Biomedical Research Networking Center on Neurodegenerative Diseases
2019-2023
Centro de Investigación Biomédica en Red
2023
Instituto de Salud Carlos III
2023
Universidad San Pablo CEU
2019-2021
Urban Institute
2021
Abstract MR-guided focused ultrasound (MRgFUS), in combination with intravenous microbubble administration, has been applied for focal temporary BBB opening patients neurodegenerative disorders and brain tumors. MRgFUS could become a therapeutic tool drug delivery of putative neurorestorative therapies. Treatment Parkinson’s disease dementia (PDD) is an important unmet need. We initiated prospective, single-arm, non-randomized, proof-of-concept, safety feasibility phase I clinical trial...
The subthalamic nucleus is the preferred neurosurgical target for deep-brain stimulation to treat cardinal motor features of Parkinson's disease. Focused ultrasound an imaging-guided method creating therapeutic lesions in structures, including nucleus.We randomly assigned, a 2:1 ratio, patients with markedly asymmetric disease who had signs not fully controlled by medication or were ineligible surgery undergo focused subthalamotomy on side opposite their main sham procedure. primary efficacy...
Abstract Background Parkinson's disease (PD) exhibits a high prevalence of dementia as severity and duration progress. Focused ultrasound (FUS) has been applied for transient blood–brain barrier (BBB) opening cortical regions in neurodegenerative disorders. The striatum is primary target delivery putative therapeutic agents PD. Objective Here, we report prospective, single‐arm, nonrandomized, proof‐of‐concept, phase I clinical trial (NCT03608553 amended) PD with to test the safety...
Unilateral magnetic resonance-guided focused ultrasound subthalamotomy (FUS-STN) has been shown to improve the cardinal motor features of Parkinson disease (PD). Whether this effect is sustained not known. This study aims report long-term outcome patients with PD treated unilateral FUS-STN.We conducted a prospective open-label asymmetrical who underwent FUS-STN. All were evaluated up 36 months after treatment. The primary was difference from baseline FUS-STN in score Movement Disorder...
In Parkinson's disease, striatal dopamine depletion produces profound alterations in the neural activity of cortico-basal ganglia motor loop, leading to dysfunctional output and parkinsonism. A key regulator is balance between excitation inhibition primary cortex, which can be assessed humans with transcranial magnetic stimulation techniques. Despite decades research, functional state cortical disease remains uncertain. Towards resolving this issue, we applied paired-pulse protocols 166...
Background Unilateral focused ultrasound subthalamotomy (FUS-STN) improves motor features of Parkinson’s disease (PD) in moderately advanced patients. The less invasive nature FUS makes its early application PD feasible. We aim to assess the safety and efficacy unilateral FUS-STN patients with than 5 years from diagnosis (early PD). Methods Prospective, open-label study. Eligible had highly asymmetrical cardinal features. primary outcome was safety, defined as treatment-related adverse...
Cognitive reserve (CR) is the mismatch between preserved cognition and neuropathological damage. Amyloidopathy in Parkinson's disease (PD) could be associated with faster progression to dementia, but putative protective effect of CR unknown.
Impulse-control disorder is a common neuropsychiatric complication in Parkinson's disease (PD) under dopamine replacement therapy. Prior studies tested the balance between enhanced desire towards reward and cognitive control deficits, hypothesized to be biased former impulse disorders. We provide evidence for this hypothesis by measuring behavioral neural patterns behind influence of sexual over response inhibition tools functional restoration using repetitive transcranial stimulation...
Essential tremor (ET) is the most common movement disorder, affecting 1% of population worldwide. There sound evidence that medically refractory improves with thalamotomy and deep brain stimulation (DBS) targeting thalamic ventralis intermedius nucleus (VIM). In last few years, incisionless technique magnetic resonance-guided focused ultrasound (MRgFUS) has been demonstrated to be an effective procedure for unilateral thalamotomy,1 a positive profile regard side effects. The thalamus...
Introduction: Impulse control disorders (ICDs) represent a side effect of dopaminergic medication in Parkinson's disease (PD). Patients experience an excessive desire toward natural rewards paired with uncontrolled actions. Yet, the precise neural and behavioral mechanisms associated ICDs and, importantly, each specific subdomain remain unclear. We aim to decipher resting-state corticolimbic functional connectivity PD patients without hypersexual ICD. Materials Methods: Seventeen...
Mild cognitive impairment (MCI) is a relevant non-motor feature in Parkinson’s disease (PD). Social cognition (SC) domain that refers to the ability decode others’ intentions and guide behavior social contexts. We aimed compare SC performance mid-stage PD patients compared healthy population according their state. Fifty-two were classified as being cognitively normal (PD-CN) or having mild (PD-MCI) following Movement Disorder Society (MDS) Level II criteria. assessment included facial...
Community resource referral systems have been implemented into care settings that serve persons with dementia but little input from caregivers. Focus groups were conducted African American, Hispanic, and Asian caregivers to describe their preferences for community information. Caregivers discussed the significance of a list caregiving self-care articulated strategies effective information delivery during medical visit. Most acknowledged needs change progression dementia, no patterns emerged...
The microtubule-associated protein tau (MAPT) H1 homozygosity (H1/H1 haplotype) is a genetic risk factor for neurodegenerative diseases, such as Parkinson's disease (PD). MAPT has been associated with conversion to PD; however, results are conflicting since some studies did not find strong influence. Cortical hypometabolism cognitive impairment in PD. In this study, we aimed evaluate the metabolic pattern nondemented PD patients H1/H1 carriers comparison H1/H2 haplotype. addition, evaluated...
Abstract Emotional information prioritizes human behavior. How much emotions influence ongoing behavior critically depends on the extent of executive control functions in a given context. One form is based stimulus–stop associations (i.e., habitual inhibition) that rapidly and effortlessly elicits over interruption So far, no behavioral accounts have explored emotional impact inhibition. We aimed to examine modulation inhibition associated psycho-physiological changes. A go/no-go association...
Abstract One common neuropsychiatric complication in patients with Parkinson’s disease treated dopamine replacement therapy is impulse control disorders. A proportion of under agonist exhibit excessive desire towards appetitive cues accompanied by lost over behaviour forms pathological gambling, hypersexuality or binge eating. The balance between enhanced sexual and cognitive changes has been hypothesized to be biased toward the former individuals Yet, some studies report no behavioural...