A5086418742- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury Research
- Transcranial Magnetic Stimulation Studies
- Ultrasound and Hyperthermia Applications
- Cardiovascular Syncope and Autonomic Disorders
- Genetic Neurodegenerative Diseases
- Autism Spectrum Disorder Research
- Epilepsy research and treatment
- Cardiac Arrest and Resuscitation
- Parkinson's Disease and Spinal Disorders
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Multiple Sclerosis Research Studies
- Stroke Rehabilitation and Recovery
- Dementia and Cognitive Impairment Research
- Nerve injury and regeneration
- Atrial Fibrillation Management and Outcomes
University Hospital HM Puerta del Sur
2017-2025
HM Hospitales
2017-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2017-2024
Instituto de Salud Carlos III
2017-2024
Camilo José Cela University
2024
Centro de Investigación Biomédica en Red
2023
Universidad San Pablo CEU
2017-2021
University of Puerto Rico, Medical Sciences Campus
2021
Cognitive Neuroimaging Lab
2009-2020
Clinica Universidad de Navarra
2020
Abstract MR-guided focused ultrasound (MRgFUS), in combination with intravenous microbubble administration, has been applied for focal temporary BBB opening patients neurodegenerative disorders and brain tumors. MRgFUS could become a therapeutic tool drug delivery of putative neurorestorative therapies. Treatment Parkinson’s disease dementia (PDD) is an important unmet need. We initiated prospective, single-arm, non-randomized, proof-of-concept, safety feasibility phase I clinical trial...
The subthalamic nucleus is the preferred neurosurgical target for deep-brain stimulation to treat cardinal motor features of Parkinson's disease. Focused ultrasound an imaging-guided method creating therapeutic lesions in structures, including nucleus.We randomly assigned, a 2:1 ratio, patients with markedly asymmetric disease who had signs not fully controlled by medication or were ineligible surgery undergo focused subthalamotomy on side opposite their main sham procedure. primary efficacy...
Intracerebral vector delivery in nonhuman primates has been a major challenge. We report successful blood-brain barrier opening and focal of adeno-associated virus serotype 9 vectors into brain regions involved Parkinson’s disease using low-intensity focus ultrasound adult macaque monkeys. Openings were well tolerated with generally no associated abnormal magnetic resonance imaging signals. Neuronal green fluorescent protein expression was observed specifically confirmed opening. Similar...
Purpose: Bone marrow stem cells (BMSC) were transplanted into the perilesional area in five patients bearing sequels of stroke, to evaluate safety procedure and tolerance cells. Methods: Cells obtained from bone samples taken same patient stereotactically implanted targets, determined using a combination images, trans-operative recording multiunit activity. The several points along tracts region. Results: No important adverse events derived surgery or transplant observed during one year...
Stereotactic thermocoagulative lesions of the subthalamic nucleus (STN) have been shown to induce significant motor improvement in patients with Parkinson's disease (PD).89 PD were treated unilateral subthalamotomy. 68 available for evaluations after 12 months, 36 at 24 months and 25 months.The Unified Disease Rating Scale (UPDRS) scores improved significantly contralaterally lesion "off" "on" states throughout follow-up, except state last evaluation. Axial features signs ipsilateral...
Abstract Background Parkinson's disease (PD) exhibits a high prevalence of dementia as severity and duration progress. Focused ultrasound (FUS) has been applied for transient blood–brain barrier (BBB) opening cortical regions in neurodegenerative disorders. The striatum is primary target delivery putative therapeutic agents PD. Objective Here, we report prospective, single‐arm, nonrandomized, proof‐of‐concept, phase I clinical trial (NCT03608553 amended) PD with to test the safety...
Unilateral magnetic resonance-guided focused ultrasound subthalamotomy (FUS-STN) has been shown to improve the cardinal motor features of Parkinson disease (PD). Whether this effect is sustained not known. This study aims report long-term outcome patients with PD treated unilateral FUS-STN.We conducted a prospective open-label asymmetrical who underwent FUS-STN. All were evaluated up 36 months after treatment. The primary was difference from baseline FUS-STN in score Movement Disorder...
Background Unilateral magnetic resonance-guided focused ultrasound (FUS) thalamotomy is efficacious for the treatment of medically refractory essential tremor (ET). Viability bilateral FUS ablation unexplored. Methods Patients diagnosed with ET and previously treated unilateral at least 5 months before underwent treatment. The timepoints were baseline (before first thalamotomy) FUS1 FUS2 (4 weeks 6 after second thalamotomy, respectively). primary endpoint was safety. Efficacy assessed...
Unilateral magnetic resonance imaging (MRI)-guided focused ultrasound subthalamotomy (FUS-STN) improves cardinal motor features among patients with asymmetrical Parkinson disease (PD). The feasibility of bilateral FUS-STN is as yet unexplored.
We studied autistics by quantitative EEG spectral and coherence analysis during three experimental conditions: basal, watching a cartoon with audio (V-A), muted band (VwA). Significant reductions were found for the absolute power density (PSD) in central region delta theta, posterior sigma beta bands, lateralized to right hemisphere. When comparing VwA versus V-A midline regions, we significant decrements of PSD delta, theta alpha, increments gamma bands. In autistics, tended show lower...
ABSTRACT Background The subthalamic nucleus (STN) is considered a key structure in motor, behavioral, and emotional control. Although identification of the functional topography STN has therapeutic implications treatment motor features Parkinson's disease (PD), details its somatotopic organization humans are not well understood. Objective aim this study was to characterize correlation with outcomes induced by subthalamotomy. Methods We used diffusion‐weighted imaging assess connectivity...
Abstract Background Unilateral focused ultrasound ventral intermediate thalamotomy (Vim‐FUS) is effective in treating Parkinson's disease (PD) tremor. Ultrasound ablation of the subthalamic nucleus (STN‐FUS) has demonstrated efficacy improving all cardinal motor features PD, including Objective To compare parkinsonian tremor control between Vim‐FUS and STN‐FUS. Methods Retrospective, two‐center study consecutive PD patients with medication‐refractory who underwent unilateral or STN‐FUS June...
Abstract Motivation This work introduces the Neuropathological Function Estimations software, designed to facilitate study of neuronal activity alterations in neurological disorders without requiring programming expertise. With its user-friendly interface, researchers can input various data types generate subject-specific functional brain models and decode neuropathological influences. Results The software’s capabilities are validated through application Alzheimer’s disease, providing...
We studied an 8-year-old boy after a near-drowning left him in vegetative state (VS) for 4 years before the study. Findings fulfilled all clinical criteria diagnosis of VS. The purpose this study was to investigate whether there significant differential activation brain response hearing his mother's voice compared with voices unknown women. data were assessed using quantitative electric tomography (QEEGt), technique that combines anatomical information by MRI EEG patterns estimate sources...
Transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) thalamotomy is a novel and effective treatment for controlling tremor in essential patients.To provide comprehensive characterization of the radiological, topographical, volumetric aspects tcMRgFUS thalamic lesion, to quantify how they relate clinical outcomes.In this study, radiological data from forty patients with medically-refractory treated unilateral were retrospectively analyzed. Treatment efficacy was assessed...
To study the Zolpidem arousing effect in persistent vegetative state (PVS) patients combining clinical evaluation, autonomic assessment by heart rate variability (HRV), and EEG records.We studied a group of 8 PVS other healthy control subjects, matched age gender. The controls received drug or placebo two experimental sessions, separated 10-14 days. first 30 minutes session were considered basal record, then was administered. All participants evaluated clinically, EEG, HRV during for 90...
Objective Subthalamotomy is an effective alternative for the treatment of Parkinson’s disease (PD). However, uncertainty about optimal target location and possibility inducing haemichorea-ballism have limited its application. We assessed correlation between topography radiofrequency-based lesions subthalamic nucleus (STN) with motor improvement emergence haemichorea-ballism. Methods Sixty-four patients PD treated subthalamotomy were evaluated preoperatively postoperatively using Unified...
Abstract Essential tremor is the most common movement disorder in adults. In patients who are not responsive to medical treatment, functional neurosurgery and, more recently, transcranial MR‐guided focused ultrasound thalamotomy considered effective therapeutic approaches. However, structural brain changes following a that mediates clinical improvement still unclear. here diffusion weighted images were acquired cohort of 24 essential before and 3 months after unilateral targeting at...
Background Unilateral focused ultrasound subthalamotomy (FUS-STN) improves motor features of Parkinson’s disease (PD) in moderately advanced patients. The less invasive nature FUS makes its early application PD feasible. We aim to assess the safety and efficacy unilateral FUS-STN patients with than 5 years from diagnosis (early PD). Methods Prospective, open-label study. Eligible had highly asymmetrical cardinal features. primary outcome was safety, defined as treatment-related adverse...
Subthalamotomy using transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) is a novel and promising treatment for Parkinson's Disease (PD). In this study, we investigate if baseline brain imaging features can be early predictors of tcMRgFUS-subthalamotomy efficacy, as well which are the post-treatment changes associated with clinical outcomes. Towards aim, functional structural neuroimaging extensive data from thirty-five PD patients enrolled in double-blind trial were...
Loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and a profound reduction striatal dopamine are two hallmarks Parkinson's disease (PD). However, it's unclear whether degeneration starts at neuronal soma or presynaptic terminals, how microstructural is linked to loss also uncertain. In this study, thirty de novo PD patients twenty healthy subjects (HS) underwent 6-[18F]-fluoro-L-dopa (FDOPA) PET MRI studies no later than 12 months from clinical diagnosis. FDOPA uptake...