A5114375671- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Nerve injury and regeneration
- Neural dynamics and brain function
- Hemispheric Asymmetry in Neuroscience
- Functional Brain Connectivity Studies
- Neuroendocrine regulation and behavior
- Motor Control and Adaptation
- EEG and Brain-Computer Interfaces
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Transcranial Magnetic Stimulation Studies
- Nuclear Receptors and Signaling
- Liver Disease Diagnosis and Treatment
- High-Temperature Coating Behaviors
- Receptor Mechanisms and Signaling
- Genetic Neurodegenerative Diseases
- Action Observation and Synchronization
- Neurogenesis and neuroplasticity mechanisms
- Hepatitis C virus research
- Advanced MRI Techniques and Applications
- Circadian rhythm and melatonin
- Sport Psychology and Performance
Leibniz University Hannover
2022-2024
Universidad de La Laguna
2013-2023
Biomedical Research Networking Center on Neurodegenerative Diseases
2013-2023
University of Mendoza
2022
Universidad Técnica de Manabí
2021
University Hospital of Zurich
2021
University of Zurich
2021
Centro de Investigación Biomédica en Red
2007-2017
Hanover College
2017
Institut de Pharmacologie et de Biologie Structurale
2016
The substantia nigra (SN) is a midbrain center composed of dopaminergic (DA-) and gamma aminobutyric acid (GABA)ergic (GABA-) neurons. In this study, we investigated the topographical relationship between both cell populations their chemical profile by using single double immunostaining for tyrosine hydroxylase (TH), glutamic decarboxylase (GAD), cholecystokinin (CCK), calretinin (CR), calbindin (CB), parvalbumin (PV), nitric oxide synthase (NOS). Our results showed that DA-cells are...
Mitophagy is essential for the health of dopaminergic neurons because mitochondrial damage a keystone Parkinson's disease. The aim present work was to study degradation mitochondria in degenerating synapse. Adult Sprague-Dawley rats and YFP-Mito-DAn mice with fluorescent were injected lateral ventricles 6-hydroxydopamine, toxic that inhibits chain blockades axonal transport. Dopaminergic terminals closest ventricle showed an fragmentation accumulation damaged 2-9 μ saccular structures...
Ascorbate (vitamin C) is a nonenzymatic antioxidant highly concentrated in the brain. In addition to mediating redox balance, ascorbate linked glutamate neurotransmission striatum, where it renders neuroprotection against excessive stimulation. Oxidative stress and glutamatergic overactivity are key biochemical features accompanying loss of dopaminergic neurons substantia nigra that characterizes Parkinson's disease (PD). At present, not clear whether antiglutamate agents might be...
Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to both familial and idiopathic forms of Parkinson's disease (PD). Neuroinflammation is a key event neurodegeneration aging, there mounting evidence LRRK2 involvement inflammatory pathways. In previous study, we described an alteration the response dermal fibroblasts from PD patients expressing G2019S R1441G mutations LRRK2. Taking advantage cellular reprogramming, generated induced pluripotent stem cell (iPSC) lines neurons...
Numerous studies suggest that the dopamine transporter (DAT), responsible for reuptake, may act as a vulnerability factor in pathogenesis of Parkinson's disease (PD) and vesicular monoamine (VMAT2), its storage, neuroprotective factor. However, relevance each on differential midbrain DA cells remains unknown. Here we studied relationship between expression pattern (mRNA protein) both transporters model PD (intracerebroventricular injection 6-OHDA rats) monkey human midbrain. Our results...