Jesús M. González‐Santiago
A5081466460- Gastric Cancer Management and Outcomes
- Hepatitis C virus research
- Colorectal Cancer Screening and Detection
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Systemic Lupus Erythematosus Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Eosinophilic Esophagitis
- Medical Imaging and Pathology Studies
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- Liver Diseases and Immunity
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Celiac Disease Research and Management
- Drug Transport and Resistance Mechanisms
- COVID-19 Clinical Research Studies
- Metabolism and Genetic Disorders
- Metastasis and carcinoma case studies
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
Instituto de Salud Carlos III
2024
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2022-2024
Universidad de Salamanca
2021-2024
Instituto de Investigación Biomédica de Salamanca
2016-2024
Complejo Hospitalario de Salamanca
2017-2023
Hospital San Pedro de Alcántara
2010-2013
Abstract Background Resection techniques for small polyps include cold snare polypectomy (CSP) and hot (HSP). This study compared CSP HSP in 5–9 mm terms of complete resection adverse events. Methods was a multicenter, randomized trial conducted seven Spanish centers between February November 2019. Patients with ≥ 1 polyp were to or HSP, regardless morphology pit pattern. After polypectomy, two marginal biopsies submitted pathologist who blinded histology. Complete defined as normal mucosa...
Abstract Background & Aims Information about the impact of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in patients with liver cancer is lacking. This study characterizes outcomes and mortality risk this population. Methods Multicentre retrospective, cross‐sectional, international SARS‐CoV‐2 infection registered between February December 2020. Clinical data at diagnosis were registered. Results Two hundred fifty from 38 centres included, 218 hepatocellular carcinoma (HCC)...
Randomized clinical trials and meta-analyses, primarily from Asian countries, have reported good effectiveness with high-dose dual therapy (HDDT) including a proton pump inhibitor (PPI) amoxicillin when prescribed as H. pylori first-line or rescue treatment. However, combining PPIs in the 1990s several European countries yielded suboptimal results.An international, multicenter, prospective non-interventional Registry (Hp-EuReg) aimed to evaluate decisions outcomes of management by...
HIV-positive patients on tenofovir hydroxyl fumarate (TDF)/emtricitabine have a lower risk of COVID-19 and hospitalization than those given other treatments. Our aim was to analyze the severity in with chronic hepatitis B (CHB) TDF or entecavir (ETV). Spanish hospital databases (n = 28) including information regarding adult CHB ETV for period February 1st November 30th 2020 were searched COVID-19, defined as positive SARS-CoV-2 polymerase chain reaction, severe COVID-19. Of 4736 patients,...
Summary Background Sofosbuvir, velpatasvir and voxilaprevir (SOF/VEL/VOX) is the recommended rescue therapy for patients with chronic hepatitis C infection who fail direct‐acting antivirals (DAAs). Data are limited on effectiveness of this treatment after current first‐line therapies. Our aim was to analyse safety SOF/VEL/VOX among failing sofosbuvir/velpatasvir (SOF/VEL) or glecaprevir/pibrentasvir (GLE/PIB). Methods Retrospective multicentre study (26 Spanish hospitals), including...
INTRODUCTION: Obeticholic acid (OCA) and fibrates therapy results in biochemical improvement placebo-controlled trials patients with primary biliary cholangitis insufficient response to ursodeoxycholic acid. There is scarce information outside of clinical trials. Therefore, we have assessed the effectiveness adverse events these treatments. METHODS: Data from included ColHai registry treated OCA, fibrates, or both were recorded during a year, as well treatment discontinuation. RESULTS:...
Abstract Background and Aims A variant (p.Arg225Trp) of peroxisomal acyl‐CoA oxidase 2 (ACOX2), involved in bile acid (BA) side‐chain shortening, has been associated with unexplained persistent hypertransaminasemia accumulation C27‐BAs, mainly 3α,7α,12α‐trihydroxy‐5β‐cholestanoic (THCA). We aimed to investigate the prevalence ACOX2 deficiency‐associated (ADAH), its response ursodeoxycholic (UDCA), elucidate pathophysiological mechanism identify other inborn errors that could cause this...
Background: non-anesthesiologist administration of propofol (NAAP) using continuous infusion systems may achieve a more sustained sedative action.Aim: to compare intermittent boluses (IB) with pump (PCI) for NAAP, targeted moderate sedation, colonoscopy.Methods: 192 consecutive outpatients were randomized receive IB (20 mg on demand) or PCI (3 mg/ kg/h plus 20 demand).Sedation could be stopped at cecal intubation the discretion endoscopist.Satisfaction rates patient, nurses and endoscopist,...
Introduction The efficacy of currently recommended third-line therapies for Helicobacter pylori is suboptimal, even that culture-guided treatments. Resistance to multiple antibiotics the major factor related treatment failure. aim this study was evaluate effectiveness and safety a 14-day therapy using high-dose amoxicillin, metronidazole esomeprazole. Material methods Multicenter open-label as register in routine clinical practice patients with two previous failures eradication therapy. A...
Percutaneous endoscopic colostomy (PEC), using the classic pull-through technique in ascending or descending colon, has been proven useful to treat chronic intestinal pseudo-obstruction. We report case of a high-surgical risk 70-year-old male with refractory pseudo-obstruction, whom colon could not be reached due tortuous left dolichocolon. Endoscopic-assisted colopexy and push proximal transverse was decided accordingly. Colopexy performed under direct vision 3 preloaded T-fasteners...
The recommended schedule for single capsule bismuth quadruple therapy (scBQT, Pylera) includes a proton pump inhibitor (PPI) two times day and three scBQT capsules four day. Four treatments are inconvenient reduce adherence. In contrast, adherence improves with schedules. clinical practice, many gastroenterologists use However, the effectiveness safety of this latter approach remain uncertain.To assess administered in patients included European Registry on Helicobacter pylori Management...