Françis Mégraud

ORCID: 0000-0002-2481-1612
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About
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Research Areas
  • Helicobacter pylori-related gastroenterology studies
  • Veterinary medicine and infectious diseases
  • Gastric Cancer Management and Outcomes
  • Eosinophilic Esophagitis
  • Gastroesophageal reflux and treatments
  • Salmonella and Campylobacter epidemiology
  • Galectins and Cancer Biology
  • Viral gastroenteritis research and epidemiology
  • Gastrointestinal disorders and treatments
  • Clostridium difficile and Clostridium perfringens research
  • Microbial Metabolites in Food Biotechnology
  • Mycobacterium research and diagnosis
  • Microscopic Colitis
  • Celiac Disease Research and Management
  • Cancer Cells and Metastasis
  • Cancer Research and Treatments
  • Antibiotic Resistance in Bacteria
  • Intestinal and Peritoneal Adhesions
  • Antimicrobial Resistance in Staphylococcus
  • Bacterial Identification and Susceptibility Testing
  • Vibrio bacteria research studies
  • Streptococcal Infections and Treatments
  • Probiotics and Fermented Foods
  • Escherichia coli research studies
  • Infective Endocarditis Diagnosis and Management

Université de Bordeaux
2016-2025

Inserm
2016-2025

Bordeaux Population Health
2016-2025

Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2024

Hôpital Pellegrin
2014-2023

Centre Hospitalier Universitaire de Bordeaux
2013-2023

Renji Hospital
2018-2021

Amsterdam University of Applied Sciences
2018-2021

Agostino Gemelli University Polyclinic
2021

Translational Research in Oncology
2016-2021

Important progress has been made in the management of Helicobacter pylori infection and this fifth edition Maastricht Consensus Report, key aspects related to clinical role H. were re-evaluated 2015. In V/Florence Conference, 43 experts from 24 countries examined new data five subdivided workshops: (1) Indications/Associations, (2) Diagnosis, (3) Treatment, (4) Prevention/Public Health, (5) Gastric Microbiota. The results individual workshops presented a final consensus voting that included...

10.1136/gutjnl-2016-312288 article EN Gut 2016-10-05

<b>Background:</b> Guidelines on the management of <i>Helicobacter pylori</i>, which cover indications for and treatment strategies, were produced in 2000. <b>Aims:</b> To update guidelines at European Helicobacter Study Group (EHSG) Third Maastricht Consensus Conference, with emphasis potential <i>H pylori</i> eradication prevention gastric cancer. <b>Results:</b> Eradication infection is recommended (<i>a</i>) patients gastroduodenal diseases such as peptic ulcer disease low grade gastric,...

10.1136/gut.2006.101634 article EN Gut 2006-12-15

Management of Helicobacter pylori infection is evolving and in this 4th edition the Maastricht consensus report aspects related to clinical role H were looked at again 2010. In Maastricht/Florence Consensus Conference 44 experts from 24 countries took active part examined key three subdivided workshops: (1) Indications contraindications for diagnosis treatment, focusing on dyspepsia, non-steroidal anti-inflammatory drugs or aspirin use, gastro-oesophageal reflux disease extraintestinal...

10.1136/gutjnl-2012-302084 article EN Gut 2012-04-05

Helicobacter pylori , a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. These modern derive their gene pools from ancestral that arose in Africa, Central Asia, East Asia. Subsequent spread attributed to migratory fluxes such as the prehistoric colonization Polynesia Americas, neolithic introduction farming Europe, Bantu expansion within slave trade.

10.1126/science.1080857 article EN Science 2003-03-06

Main Recommendations Patients with chronic atrophic gastritis or intestinal metaplasia (IM) are at risk for gastric adenocarcinoma. This underscores the importance of diagnosis and stratification these patients. High definition endoscopy chromoendoscopy (CE) is better than high white-light alone this purpose. Virtual CE can guide biopsies staging metaplastic changes target neoplastic lesions. Biopsies should be taken from least two topographic sites (antrum corpus) labelled in separate...

10.1055/a-0859-1883 article EN Endoscopy 2019-03-06

<h3>Objective</h3> Resistance to antibiotics is the major cause of treatment failure <i>Helicobacter pylori</i> infection. A study was conducted assess prospectively antibacterial resistance rates <i>H in Europe and link between outpatient antibiotic use levels different countries. <h3>Design</h3> Primary were determined from April 2008 June 2009 18 European Data on yearly cumulative over several years systemic agents ambulatory care for period 2001–8 expressed Defined Daily Doses (DDD) per...

10.1136/gutjnl-2012-302254 article EN Gut 2012-05-12

Helicobacter pylori Infection is formally recognised as an infectious disease, entity that now included in the International Classification of Diseases 11th Revision. This principle leads to recommendation all infected patients should receive treatment. In context wide clinical spectrum associated with gastritis, specific issues persist and require regular updates for optimised management. The identification distinct scenarios, proper testing adoption effective strategies prevention gastric...

10.1136/gutjnl-2022-327745 article EN Gut 2022-08-08

Atrophic gastritis, intestinal metaplasia, and epithelial dysplasia of the stomach are common associated with an increased risk for gastric cancer. In absence guidelines, there is wide disparity in management patients these premalignant conditions. The European Society Gastrointestinal Endoscopy (ESGE), Helicobacter Study Group (EHSG), Pathology (ESP) Sociedade Portuguesa de Endoscopia Digestiva (SPED) have therefore combined efforts to develop evidence-based guidelines on precancerous...

10.1055/s-0031-1291491 article EN Endoscopy 2011-12-23

Campylobacter pylori infection has been recognized as being strongly associated with chronic gastritis and duodenal ulceration, but the prevalence of C. in a normal population is not known. A serological survey was conducted four countries different geographical socioeconomic status, randomly chosen representative possible, by using an enzyme-linked immunosorbent assay (ELISA) sonic extract two strains antigen. The test had specificity 94% when 600 ELISA units used threshold. In France, few...

10.1128/jcm.27.8.1870-1873.1989 article EN Journal of Clinical Microbiology 1989-08-01

Journal Article The Cohort Effect and Helicobacter pylori Get access N. Banatvala, Banatvala Reprints or correspondence: Dr. Nicholas Department of Epidemiology Medical Statistics, London Hospital College at QMW, Mile End Road, E1 4NS, UK. Search for other works by this author on: Oxford Academic PubMed Google Scholar K. Mayo, Mayo F. Megraud, Megraud R. Jennings, Jennings J. Deeks, Deeks A. Feldman Infectious Diseases, Volume 168, Issue 1, July 1993, Pages 219–221,...

10.1093/infdis/168.1.219 article EN The Journal of Infectious Diseases 1993-07-01

A model was developed to study inhibitors present in feces which prevent the use of PCR for detection Helicobacter pylori. DNA fragment amplified with same primers as H. pylori used spike samples before extraction by a modified QIAamp tissue method. Inhibitors, separated on an Ultrogel AcA44 column, were characterized. Inhibitors are complex polysaccharides possibly originating from vegetable material diet.

10.1128/jcm.35.4.995-998.1997 article EN Journal of Clinical Microbiology 1997-04-01

This consensus report of the EGILS (European Gastro-Intestinal Lymphoma Study) group includes recommendations on management gastric extranodal marginal zone B-cell lymphoma MALT. They are based data from literature and intensive discussions votings experts during their annual meetings.

10.1136/gut.2010.224949 article EN Gut 2011-02-11

Objective A global consensus meeting was held to review current evidence and knowledge gaps propose collaborative studies on population-wide screening eradication of Helicobacter pylori for prevention gastric cancer (GC). Methods 28 experts from 11 countries reviewed the modified statements using Delphi method, with level predefined as ≥80% agreement each statement. The Grading Recommendation Assessment, Development Evaluation (GRADE) approach followed. Results Consensus reached in 26...

10.1136/gutjnl-2020-322368 article EN Gut 2020-10-01

As the clinical implications of Helicobacter pylori infection in children and adolescents continue to evolve, ESPGHAN NASPGHAN jointly renewed guidelines using a standardized evidence-based approach develop updated recommendations for North America Europe.An international panel 11 pediatric gastroenterologists, 2 epidemiologists, 1 microbiologist, pathologist was selected by societies that developed based on Delphi process with anonymous voting final face-to-face meeting. A systematic...

10.1097/mpg.0b013e3182227e90 article EN Journal of Pediatric Gastroenterology and Nutrition 2011-05-07

The stomach bacterium Helicobacter pylori is one of the most prevalent human pathogens. It has dispersed globally with its host, resulting in a distinct phylogeographic pattern that can be used to reconstruct both recent and ancient migrations. extant European population H. known hybrid between Asian African bacteria, but there exist different hypotheses about when where hybridization took place, reflecting complex demographic history Europeans. Here, we present 5300-year-old genome from...

10.1126/science.aad2545 article EN Science 2016-01-07

Objective Our aim was to prospectively assess the antibiotic resistance rates in Helicobacter pylori strains Europe 2018 and study link between consumption community H. levels different countries. Design The proportion of primary cases their corresponding risk factors were investigated 24 centres from 18 European countries according a standardised protocol. Data on collected for period 2008–2017. data assessed using generalised linear mixed models. model with best fit selected by means...

10.1136/gutjnl-2021-324032 article EN Gut 2021-04-09
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