A5022224649- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Advanced Chemical Sensor Technologies
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Biochemical Analysis and Sensing Techniques
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- Analytical Chemistry and Chromatography
- Celiac Disease Research and Management
- Gastrointestinal disorders and treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Immunodeficiency and Autoimmune Disorders
- Microscopic Colitis
- Gas Sensing Nanomaterials and Sensors
- Gastrointestinal motility and disorders
- Veterinary medicine and infectious diseases
- Galectins and Cancer Biology
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Lymphoma Diagnosis and Treatment
Riga East University Hospital
2016-2025
University of Latvia
2016-2025
Latvian Environment, Geology and Meteorology Centre (Latvia)
2022-2025
Riga Technical College
2024
Centre For Digestive Diseases
2012-2023
General Department of Preventive Medicine
2023
Research Institute of Therapy and Preventive Medicine
2018-2023
Faculty (United Kingdom)
2012-2022
Technion – Israel Institute of Technology
2019
Latvia University of Life Sciences and Technologies
2018
Main Recommendations Patients with chronic atrophic gastritis or intestinal metaplasia (IM) are at risk for gastric adenocarcinoma. This underscores the importance of diagnosis and stratification these patients. High definition endoscopy chromoendoscopy (CE) is better than high white-light alone this purpose. Virtual CE can guide biopsies staging metaplastic changes target neoplastic lesions. Biopsies should be taken from least two topographic sites (antrum corpus) labelled in separate...
Helicobacter pylori Infection is formally recognised as an infectious disease, entity that now included in the International Classification of Diseases 11th Revision. This principle leads to recommendation all infected patients should receive treatment. In context wide clinical spectrum associated with gastritis, specific issues persist and require regular updates for optimised management. The identification distinct scenarios, proper testing adoption effective strategies prevention gastric...
Objective The incidence of colorectal cancer (CRC) declines among subjects aged 50 years and above. An opposite trend appears younger adults. In Europe, data on CRC adults are lacking. We therefore aimed to analyse European trends in mortality than years. Design Data age-related between 1990 2016 were retrieved from national regional registries. Trends analysed by Joinpoint regression expressed as annual percent change. Results 143.7 million people 20–49 20 countries. Of them, 187 918...
Population-based screening for early detection and treatment of colorectal cancer (CRC) precursor lesions, using evidence-based methods, can be effective in populations with a significant burden the disease provided services are high quality. Multidisciplinary, guidelines quality assurance CRC diagnosis have been developed by experts project co-financed European Union. The 450-page were published book format Commission 2010. They include 10 chapters over 250 recommendations, individually...
Upper digestive endoscopy with biopsy and histopathological evaluation of the material is standard method for diagnosing gastric cancer (GC). However, this procedure may not be widely available screening in developing world, whereas developed countries frequently used without major clinical gain. There a high demand simple non-invasive test selecting individuals at increased risk that should undergo endoscopic examination. Here, we studied feasibility nanomaterial-based breath identifying GC...
We report on an ultrasensitive, molecularly modified silicon nanowire field effect transistor that brings together the lock-and-key and cross-reactive sensing worlds for diagnosis of (gastric) cancer from exhaled volatolome. The sensor is able to selectively detect volatile organic compounds (VOCs) are linked with gastric conditions in breath discriminate them environmental VOCs exist samples but do not relate per se. Using collected actual patients volunteers who have cancer, blind analysis...
Two of the biggest challenges in medicine today are need to detect diseases a noninvasive manner and differentiate between patients using single diagnostic tool. The current study targets these two by developing molecularly modified silicon nanowire field effect transistor (SiNW FET) showing its use detection classification many disease breathprints (lung cancer, gastric asthma, chronic obstructive pulmonary disease). fabricated SiNW FETs characterized optimized based on training set that...
The best approach for Helicobacter pylori management remains unclear. An audit process is essential to ensure clinical practice aligned with standards of care.International multicentre prospective non-interventional registry starting in 2013 aimed evaluate the decisions and outcomes H. by European gastroenterologists. Patients were registered an e-CRF AEG-REDCap. Variables included demographics, previous eradication attempts, prescribed treatment, adverse events outcomes. Data monitoring was...
<h3>Objectives</h3> Timely detection of gastric cancer (GC) and the related precancerous lesions could provide a tool for decreasing both mortality incidence. <h3>Design</h3> 968 breath samples were collected from 484 patients (including 99 with GC) two different analyses. The first sample was analysed by gas chromatography linked to mass spectrometry (GCMS) while applying t test multiple corrections (p value<0.017); second cross-reactive nanoarrays combined pattern recognition. For...
INTRODUCTION: Antibiotic resistance is one of the main factors that determine efficacy treatments to eradicate Helicobacter pylori infection. Our aim was evaluate effectiveness first-line and rescue against H. in Europe according antibiotics resistance. METHODS: Prospective, multicenter, international registry on management (European Registry Management). All infected culture-diagnosed adult patients registered Spanish Association Gastroenterology-Research Electronic Data Capture from 2013...
There is evidence that the prevalence of allergies and asthma differs between populations in western eastern Europe. This study investigated wheezing, rhinitis eczema among schoolchildren urban rural areas Scandinavia formerly socialist countries Eastern A total 79,000 children from two age groups (13-14 yrs 6-7 yrs) 18 centres responded to a questionnaire within International Study Asthma Allergy Children (ISAAC). The 12 month period symptoms asthma, allergic rhinoconjunctivitis atopic was...
Although colorectal cancer (CRC) screening is included in organized programs of many countries worldwide, there still a place for better tools. In this study, 418 breath samples were collected from 65 patients with CRC, 22 advanced or nonadvanced adenomas, and 122 control cases. All patients, including the controls, had undergone colonoscopy. The analysed two different techniques. first technique relied on gas chromatography coupled mass spectrometry (GC-MS) identification quantification...
INTRODUCTION: The safety of Helicobacter pylori eradication treatments and to what extent adverse events (AEs) influence therapeutic compliance in clinical practice are hardly known. Our aim was assess the frequency, type, intensity, duration AEs, their impact on compliance, for most frequently used “European Registry management.” METHODS: Systematic prospective noninterventional registry European gastroenterologists (27 countries, 300 investigators) management H. infection routine practice....
Objective New screening tests for colorectal cancer (CRC) are rapidly emerging. Conducting trials with mortality reduction as the end point supporting their adoption is challenging. We re-examined principles underlying evaluation of new non-invasive in view technological developments and identification biomarkers. Design A formal consensus approach involving a multidisciplinary expert panel revised eight previously established principles. Results Twelve newly stated emerged. Effectiveness...